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Mothers against decapentaplegic homolog 6

Summary

UniProt ID

O43541

Gene Symbol

SMAD6
MADH6

Organism

Homo sapiens (human)

External Links

GlyGen: O43541
PubChem: O43541
The Human Metabolome Database: HMDBP14504
The O-GlcNAc Database: O43541

Annotation

Keyword

Alternative splicing
Craniosynostosis
Disease variant
Isopeptide bond
Metal-binding
Methylation
Nucleus
Phosphoprotein
Reference proteome
Transcription regulation
Ubl conjugation
Zinc

Gene Ontology (GO)

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GO Term
aortic valve morphogenesis
pulmonary valve morphogenesis
regulation of transcription by RNA polymerase II
transforming growth factor beta receptor signaling pathway
BMP signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of BMP signaling pathway
response to lipopolysaccharide
response to laminar fluid shear stress
response to estrogen

Displaying **all 9** entries
GO Term
nucleoplasm
Golgi apparatus
cytosol
chromatin
nucleus
cytoplasm
protein-containing complex
heteromeric SMAD protein complex
nuclear body

Displaying entries **1 - 10** of 12 in total

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GO Term
chromatin binding
metal ion binding
type I activin receptor binding
transcription regulator inhibitor activity
transcription cis-regulatory region binding
ubiquitin protein ligase binding
type I transforming growth factor beta receptor binding
identical protein binding
I-SMAD binding
protein sequestering activity

Annotation information from UniProt.

Sequence

MFRSKRSGLVRRLWRSRVVPDREEGGSGGGGGGDEDGSLGSRAEPAPRAREGGGCGRSEVRPVAPRRPRDAVGQRGAQGAGRRRRAGGPPRPMSEPGAGAGSSLLDVAEPGGPGWLPESDCETVTCCLFSERDAAGAPRDASDPLAGAALEPAGGGRSREARSRLLLLEQELKTVTYSLLKRLKERSLDTLLEAVESRGGVPGGCVLVPRADLRLGGQPAPPQLLLGRLFRWPDLQHAVELKPLCGCHSFAAAADGPTVCCNPYHFSRLCGPESPPPPYSRLSPRDEYKPLDLSDSTLSYTETEATNSLITAPGEFSDASMSPDATKPSHWCSVAYWEHRTRVGRLYAVYDQAVSIFYDLPQGSGFCLGQLNLEQRSESVRRTRSKIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAPGGRALVVRKVPPGYSIKVFDFERSGLQHAPEPDAADGPYDPNSVRISFAKGWGPCYSRQFITSCPCWLEILLNNPR

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites