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Calreticulin

Summary

Gene Symbol

Calr

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

41166

PubChem

41166

Alliance of Genome Resources

FB:FBgn0005585

Annotation

Keyword

Calcium
Chaperone
Direct protein sequencing
Disulfide bond
Endoplasmic reticulum
Lectin
Metal-binding
Proteomics identification
Reference proteome
Repeat
Signal
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P29413
Q53YH3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein folding	IBA IEA
olfactory behavior	IMP	12756487
sleep	IMP	18430954
ERAD pathway	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

cellular process [inference]

protein folding

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

multicellular organismal process [inference]

behavior [inference]

chemosensory behavior [inference]

olfactory behavior

sleep

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

ERAD pathway

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

ERAD pathway

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
fusome	IDA	18355804
endoplasmic reticulum membrane	IBA
endoplasmic reticulum lumen
endoplasmic reticulum	IEA
endomembrane system	HDA	19317464

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

fusome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
calcium ion binding	IBA IEA
unfolded protein binding	IEA
carbohydrate binding

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

unfolded protein binding

carbohydrate binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Calreticulin

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
calcium ion binding
unfolded protein binding

Displaying **all 4** entries
InterPro
Calreticulin/calnexin, P domain superfamily
Calreticulin/calnexin, conserved site
Calreticulin/calnexin
Concanavalin A-like lectin/glucanase domain superfamily

Alliance of Genome Resources

Expression

Displaying **all 6** entries
Location	References
extracellular space	PMID:16670001
endomembrane system	PMID:19317464
membrane	FB:FBrf0231198
neuronal cell body	PMID:14508319
perinuclear region of cytoplasm	PMID:14508319
fusome	PMID:18355804

Disease

Disease Ontology

Displaying entries **1 - 10** of 25 in total

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DO ID	Disease Name	Source
DOID:0050731	vitamin B12 deficiency	Alliance of Genome Resources
DOID:0050866	oral squamous cell carcinoma	Alliance of Genome Resources
DOID:10534	stomach cancer	Alliance of Genome Resources
DOID:1324	lung cancer	Alliance of Genome Resources
DOID:14330	Parkinson's disease	Alliance of Genome Resources
DOID:1520	colon carcinoma	Alliance of Genome Resources
DOID:169	neuroendocrine tumor	Alliance of Genome Resources
DOID:219	colon cancer	Alliance of Genome Resources
DOID:2224	essential thrombocythemia	Alliance of Genome Resources
DOID:2228	thrombocytosis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 51 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	811		HGNC:1455
Mus musculus	12317		MGI:88252
Danio rerio	30248		ZFIN:ZDB-GENE-000208-17
Rattus norvegicus	64202		RGD:620288
Mus musculus	73316		MGI:1920566
Mus musculus	108802		MGI:2140435
Homo sapiens	125972		HGNC:20407
Caenorhabditis elegans	178997		WB:WBGene00000802
Danio rerio	325317		ZFIN:ZDB-GENE-030131-4042
Rattus norvegicus	364529		RGD:1309243

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Supported by JST NBDC Grant Number JPMJND2204

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GlyCosmos Portal v4.1.0

Last updated: December 9, 2024