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Standards Ontologies Notations
mannosidase alpha class 2A member 2

Summary
Gene Symbol
  • MAN2A2
Aliases
  • HsT19662
  • MANA2X
Organism
Homo sapiens (human)
NCBI Gene
4122
HGNC
6825
KEGG Gene ID
hsa:4122
PubChem
4122
Alliance of Genome Resources
Annotation
Keyword
  • Alternative splicing
  • Disulfide bond
  • Glycoprotein
  • Glycosidase
  • Golgi apparatus
  • Metal-binding
  • Proteomics identification
  • Reference proteome
  • Signal-anchor
  • Transmembrane helix
  • Zinc
Proteins
Displaying 1 entry
UniProt Protein Name
P49641
  • Alpha-mannosidase IIx
  • Mannosidase alpha class 2A member 2
  • Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
Annotation information from UniProt.
Gene Ontology (GO)
Displaying all 3 entries
GO Term Evidence Code PMID
protein glycosylation
mannose metabolic process
N-glycan processing
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Eukaryota
Group Name
alpha mannosidase
Functional Category
  • G: Carbohydrate transport and metabolism
  • J: Translation, ribosomal structure and biogenesis
Displaying all 5 entries
Gene Ontology
alpha-mannosidase activity
catalytic activity
hydrolase activity, acting on glycosyl bonds
mannose metabolic process
metal ion binding
Displaying all 8 entries
InterPro
Galactose mutarotase-like domain superfamily
Glycoside hydrolase 38, N-terminal domain superfamily
Glycoside hydrolase families 57/38, central domain superfamily
Glycoside hydrolase family 38, N-terminal domain
Glycoside hydrolase family 38, central domain superfamily
Glycoside hydrolase family 38, central domain
Glycoside hydrolase/deacetylase, beta/alpha-barrel
Glycosyl hydrolase family 38, C-terminal
KEGG BRITE Database
Orthology
K01231
Name
alpha-mannosidase II [EC:3.2.1.114]
References
Reactions
Displaying 1 entry
KEGG Reaction Enzyme Acceptor Product
R05984
Rhea

RHEA:56052

H2O
α-D-mannopyranose
Enzyme
PMID
Disease
Disease Ontology
Displaying 1 entry
DO ID Disease Name Source
DOID:5419 schizophrenia
Ortholog
Displaying entries 71 - 80 of 93 in total
Species Gene ID OrthoDB Alliance of Genome Resources Orthologous MAtrix
109051095 CYPCA141192
109530362 HIPCM03998
111228707 SERDU10812
111563148 AMPOC02335
112921479 VULVU01607
113027015 ASTCA38691
113441970 PSETE14191
113588518 ELEEL41665
114035736 VOMUR03497
114584355 PODMU03787
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024