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Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cytoplasm
Direct protein sequencing
Disease variant
Epilepsy
Methylation
NAD
Oxidoreductase
Phosphoprotein
Proteomics identification
Reference proteome
Tricarboxylic acid cycle
Ubl conjugation

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A5K1VW95
V9HWF2
P40925	Aromatic alpha-keto acid reductase Cytosolic malate dehydrogenase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
malate metabolic process	IBA
NADH metabolic process	IBA IDA	34547241
NADP metabolic process	IDA	34547241
oxaloacetate metabolic process	IBA
tricarboxylic acid cycle	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

organonitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

biosynthetic process [inference]

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

dicarboxylic acid metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

tricarboxylic acid cycle

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

dicarboxylic acid metabolic process [inference]

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

dicarboxylic acid metabolic process [inference]

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

organonitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

dicarboxylic acid metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process

NAD metabolic process [inference]

NADH metabolic process

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GO Term	Evidence Code	PMID
cytosol	IBA IDA TAS
cytoplasm	IDA	34547241
centrosome	IDA
extracellular space	HDA	22664934
mitochondrion

GO Hierarchy

cellular component

cellular anatomical entity [inference]

microtubule organizing center [inference]

centrosome

cytosol

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

mitochondrion

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
hydroxyphenylpyruvate reductase activity	IEA
L-malate dehydrogenase activity	EXP IBA	3052244
malic enzyme activity	TAS	8786100
diiodophenylpyruvate reductase activity	IEA
protein binding	IPI	21044950

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

malate dehydrogenase activity [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000014641

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00025

Name

malate dehydrogenase [EC:1.1.1.37]

References

Rhea

RHEA:10780

(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD⁺

H⁺ + 3-(4-hydroxyphenyl)pyruvate + NADH

Enzyme

PMID

RHEA:21432

(S)-malate + NAD⁺

H⁺ + oxaloacetate + NADH

Enzyme

PMID

RHEA:20293

NAD⁺ + 3-(3,5-diiodo-4-hydroxyphenyl)lactate

H⁺ + NADH + 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate

Enzyme

1.1.1.96

PMID

3052244

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:0050433	fatal familial insomnia	DisGeNET
DOID:0050572	cone-rod dystrophy	DisGeNET
DOID:0050819	obsolete Matthew-Wood syndrome	DisGeNET
DOID:0110423	dilated cardiomyopathy 1C	DisGeNET
DOID:0110424	dilated cardiomyopathy 1CC	DisGeNET
DOID:0110425	dilated cardiomyopathy 1A	DisGeNET
DOID:0110426	dilated cardiomyopathy 1D	DisGeNET
DOID:0110427	dilated cardiomyopathy 1V	DisGeNET
DOID:0110428	dilated cardiomyopathy 1AA	DisGeNET
DOID:0110429	dilated cardiomyopathy 1H	DisGeNET

The Human Phenotype Ontology

Displaying entries **1 - 10** of 16 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000232	Everted lower lip vermilion
HP:0000253	Progressive microcephaly
HP:0000348	High forehead
HP:0001250	Seizure
HP:0001263	Global developmental delay
HP:0001276	Hypertonia
HP:0001338	Partial agenesis of the corpus callosum
HP:0001510	Growth delay
HP:0002521	Hypsarrhythmia

Displaying 1 entry
Disease ID	Disease Name
OMIM:618959	developmental and epileptic encephalopathy, 88

PubChem Disease

MedGen Diseases

Developmental and epileptic encephalopathy, 88

OMIM Phenotypes

DEVELOPMENTAL AND EPILEPTIC ENCEPHALOPATHY 88; DEE88

KEGG Diseases

Early infantile epileptic encephalopathy

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **1 - 10** of **104** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	179041	WB:WBGene00018491
Drosophila melanogaster	34414	FB:FBgn0262782
Callorhinchus milii	103177941		CALMI14184
Latimeria chalumnae	102357680		LATCH18020
Danio rerio	335715	ZFIN:ZDB-GENE-030131-7655	DANRE12103
Danio rerio	399662	ZFIN:ZDB-GENE-040204-1	DANRE18223
Astyanax mexicanus	103033607		ASTMX03263
Astyanax mexicanus	103036835		ASTMX11574
Ictalurus punctatus	108258652		ICTPU21472
Ictalurus punctatus	108269785		ICTPU35976

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Other Information

Tools

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Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements