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beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase

Summary

Gene Symbol

MGAT3

Aliases

GNT-III

Organism

Homo sapiens (human)

External Links

NCBI Gene

4248

GGDB ID

gg127

HGNC

7046

mRNA

NM_002409

map

22q13.1

Protein

NP_002400

OMIM

604621

KEGG Gene ID

hsa:4248

PubChem

4248

Alliance of Genome Resources

HGNC:7046

Annotation

Keyword

Glycoprotein
Glycosyltransferase
Golgi apparatus
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q09327	N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
cellular response to oxidative stress	ISS
protein N-linked glycosylation	ISS
positive regulation of protein localization to early endosome	ISS
protein localization	IMP	19403558
amyloid-beta metabolic process	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

amyloid-beta metabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

amyloid-beta metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation

carbohydrate derivative metabolic process [inference]

amino sugar metabolic process [inference]

glucosamine-containing compound metabolic process [inference]

N-acetylglucosamine metabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

amyloid-beta metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

cellular process [inference]

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

cellular response to oxidative stress

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of protein catabolic process in the vacuole [inference]

negative regulation of lysosomal protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of protein catabolic process in the vacuole [inference]

negative regulation of lysosomal protein catabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of protein catabolic process in the vacuole [inference]

negative regulation of lysosomal protein catabolic process

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of protein catabolic process in the vacuole [inference]

negative regulation of lysosomal protein catabolic process

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of protein catabolic process in the vacuole [inference]

negative regulation of lysosomal protein catabolic process

regulation of protein catabolic process in the vacuole [inference]

negative regulation of protein catabolic process in the vacuole [inference]

negative regulation of lysosomal protein catabolic process

regulation of lysosomal protein catabolic process [inference]

negative regulation of lysosomal protein catabolic process

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of protein catabolic process in the vacuole [inference]

negative regulation of lysosomal protein catabolic process

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of protein catabolic process in the vacuole [inference]

negative regulation of lysosomal protein catabolic process

regulation of protein catabolic process in the vacuole [inference]

negative regulation of protein catabolic process in the vacuole [inference]

negative regulation of lysosomal protein catabolic process

regulation of lysosomal protein catabolic process [inference]

negative regulation of lysosomal protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of protein catabolic process in the vacuole [inference]

negative regulation of lysosomal protein catabolic process

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of protein catabolic process in the vacuole [inference]

negative regulation of lysosomal protein catabolic process

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of protein catabolic process in the vacuole [inference]

negative regulation of lysosomal protein catabolic process

regulation of protein catabolic process in the vacuole [inference]

negative regulation of protein catabolic process in the vacuole [inference]

negative regulation of lysosomal protein catabolic process

regulation of lysosomal protein catabolic process [inference]

negative regulation of lysosomal protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of protein catabolic process in the vacuole [inference]

negative regulation of lysosomal protein catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of protein catabolic process in the vacuole [inference]

negative regulation of lysosomal protein catabolic process

regulation of protein catabolic process in the vacuole [inference]

negative regulation of protein catabolic process in the vacuole [inference]

negative regulation of lysosomal protein catabolic process

regulation of lysosomal protein catabolic process [inference]

negative regulation of lysosomal protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of protein catabolic process in the vacuole [inference]

negative regulation of lysosomal protein catabolic process

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to endosome [inference]

positive regulation of protein localization to early endosome

regulation of protein localization to endosome [inference]

regulation of protein localization to early endosome [inference]

positive regulation of protein localization to early endosome

positive regulation of protein localization to endosome [inference]

positive regulation of protein localization to early endosome

regulation of locomotion [inference]

regulation of cell motility [inference]

regulation of cell migration

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to endosome [inference]

positive regulation of protein localization to early endosome

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of protein catabolic process in the vacuole [inference]

negative regulation of lysosomal protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of protein catabolic process in the vacuole [inference]

negative regulation of lysosomal protein catabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of protein catabolic process in the vacuole [inference]

negative regulation of lysosomal protein catabolic process

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to endosome [inference]

positive regulation of protein localization to early endosome

regulation of cellular localization [inference]

regulation of protein localization [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to endosome [inference]

positive regulation of protein localization to early endosome

regulation of protein localization to endosome [inference]

regulation of protein localization to early endosome [inference]

positive regulation of protein localization to early endosome

positive regulation of protein localization to endosome [inference]

positive regulation of protein localization to early endosome

regulation of cell motility [inference]

regulation of cell migration

Displaying **all 2** entries
GO Term	Evidence Code	PMID
membrane	TAS	8370666
Golgi membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
glycosyltransferase activity	IBA
protein binding	IPI	32296183
beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity	IMP ISS TAS	19403558

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity

UDP-glycosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity

hexosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity

catalytic activity, acting on a protein [inference]

catalytic activity, acting on a glycoprotein [inference]

beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000128268

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg127

Gene Symbol

MGAT3

Reactions

Displaying 1 entry
Donor	Acceptor	Product	Reference
UDP-GlcNAc	G39213VZ	G59471TH	6222042

Displaying **all 3** entries
Donor	Acceptor	Product	Reference
UDP-GlcNAc	G39213VZ	G59471TH	10024668 6222042
UDP-GlcNAc	G27919IH	G85767HW	6222042
UDP-GlcNAc	G80858MF	G30159WR	6222042

Displaying **all 5** entries
Donor	Acceptor	Reference
UDP-GlcNAc	G78059CC	6222042
UDP-GlcNAc	G99858XP	6222042
UDP-GlcNAc	G77252PU	6222042
UDP-GlcNAc	G58667NI	6222042
UDP-GlcNAc	G07483YN	6222042

Orthologous Gene

Displaying **all 3** entries
Species	Protein	mRNA
Rattus norvegicus	NP_062112	NM_019239
Drosophila melanogaster	NP_723787	NM_165027
Mus musculus	NP_034925	NM_010795

KEGG BRITE Database

Orthology

K00737

Name

beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase [EC:2.4.1.144]

References

9061364

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R05986	2.4.1.144	G39213VZ	G59471TH

Rhea

RHEA:15509

UDP-N-acetyl-α-D-glucosamine

H⁺ + UDP

Enzyme

2.4.1.144

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 33 in total

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DO ID	Disease Name	Source
DOID:0050581	brachydactyly	DisGeNET
DOID:0050589	inflammatory bowel disease	DisGeNET
DOID:0080348	Alzheimer's disease 1	DisGeNET
DOID:0110035	Alzheimer's disease 2	DisGeNET
DOID:0110037	Alzheimer's disease 5	DisGeNET
DOID:0110038	Alzheimer's disease 6	DisGeNET
DOID:0110039	Alzheimer's disease 7	DisGeNET
DOID:0110041	Alzheimer's disease 8	DisGeNET
DOID:0110043	Alzheimer's disease 10	DisGeNET
DOID:0110044	Alzheimer's disease 11	DisGeNET

Ortholog

Displaying entries **1 - 10** of 72 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	318981	FB:FBgn0051849
Callorhinchus milii	103172616		CALMI47149
Latimeria chalumnae	102355106		LATCH00379
Danio rerio	553676	ZFIN:ZDB-GENE-050522-249
Danio rerio	570828	ZFIN:ZDB-GENE-130820-2
Ictalurus punctatus	108272883		ICTPU03354
Electrophorus electricus	113580225		ELEEL04463
Salmo salar	106590617		SALSA18276
Salmo salar	106590738		SALSA18276
Salmo trutta	115147444		SALTR38272

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

International Collaboration

Acknowledgements