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wolfram syndrome 1

Summary

Gene Symbol

wfs1

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

42679

PubChem

42679

Alliance of Genome Resources

FB:FBgn0039003

Annotation

Keyword

Alternative splicing
Endoplasmic reticulum
Glycoprotein
Mitochondrion
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8IMZ9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
calcium ion homeostasis	IBA
endoplasmic reticulum unfolded protein response	IBA
negative regulation of gene expression	IMP	29357349
adult locomotory behavior	IGI IMP	29357349

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

endoplasmic reticulum unfolded protein response

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

endoplasmic reticulum unfolded protein response

multicellular organismal process [inference]

behavior [inference]

locomotory behavior [inference]

adult locomotory behavior

adult behavior [inference]

adult locomotory behavior

homeostatic process [inference]

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

calcium ion homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

endoplasmic reticulum unfolded protein response

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

endoplasmic reticulum unfolded protein response

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular process [inference]

signal transduction [inference]

endoplasmic reticulum unfolded protein response

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

Displaying **all 2** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	IBA
mitochondrion

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying 1 entry
GO Term	Evidence Code	PMID
ubiquitin protein ligase binding	ISS

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

enzyme binding [inference]

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Wolframin

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
calcium ion homeostasis
endoplasmic reticulum unfolded protein response

Displaying **all 7** entries
InterPro
Tetratricopeptide-like helical domain superfamily
Wolframin family
Wolframin, EF-hand domain
Wolframin, OB-fold domain
Wolframin, Sel1-like repeat
Wolframin, cysteine-rich domain
Wolframin

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
membrane	FB:FBrf0231198

Disease

Disease Ontology

Displaying entries **1 - 10** of 17 in total

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DO ID	Disease Name	Source
DOID:83	cataract	Alliance of Genome Resources
DOID:0050563	nonsyndromic deafness	Alliance of Genome Resources
DOID:0080584	autosomal dominant Wolfram syndrome	Alliance of Genome Resources
DOID:0110241	cataract 41	Alliance of Genome Resources
DOID:0110584	autosomal dominant nonsyndromic deafness 6	Alliance of Genome Resources
DOID:0110629	Wolfram syndrome 1	Alliance of Genome Resources
DOID:0111441	optic atrophy 1	Alliance of Genome Resources
DOID:10003	sensorineural hearing loss	Alliance of Genome Resources
DOID:10603	glucose intolerance	Alliance of Genome Resources
DOID:10632	Wolfram syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 44 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Homo sapiens	7466		HGNC:12762
Mus musculus	22393		MGI:1328355
Rattus norvegicus	83725		RGD:68954
Danio rerio	556580		ZFIN:ZDB-GENE-050809-19
Danio rerio	566876		ZFIN:ZDB-GENE-080225-11
Drosophila ananassae	6500780	7217_1:0006d9
Drosophila yakuba	6537787	7245_1:002ce4
Drosophila erecta	6554917	7220_1:000908
Drosophila grimshawi	6567500	7222_0:000b2a
Drosophila mojavensis	6581241	7230_1:0023db