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Cadherin 99C

Summary

Gene Symbol

Cad99C

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

43528

PubChem

43528

Alliance of Genome Resources

FB:FBgn0039709

Annotation

Keyword

Calcium
Cell membrane
Cell projection
Endosome
Glycoprotein
Immunity
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9VAF5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 14 in total

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GO Term	Evidence Code	PMID
regulation of follicle cell microvillus length	IMP	16260500
cell-cell adhesion mediated by cadherin	ISM	11162110
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	ISS NAS	10908592 11162110
calcium-mediated signaling	IGI	25639794
homophilic cell adhesion via plasma membrane adhesion molecules	IEA

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

organ or tissue specific immune response [inference]

mucosal immune response

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion

cell-cell adhesion mediated by cadherin

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

signal transduction [inference]

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

cellular process involved in reproduction in multicellular organism [inference]

egg coat formation [inference]

vitelline membrane formation [inference]

vitelline membrane formation involved in chorion-containing eggshell formation

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

apical protein localization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cellular component assembly involved in morphogenesis [inference]

vitelline membrane formation [inference]

vitelline membrane formation involved in chorion-containing eggshell formation

extracellular matrix assembly [inference]

vitelline membrane formation [inference]

vitelline membrane formation involved in chorion-containing eggshell formation

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

microvillus organization [inference]

follicle cell microvillus organization

regulation of cellular component size [inference]

regulation of cell size [inference]

regulation of follicle cell microvillus length

regulation of cell projection size [inference]

regulation of microvillus length [inference]

regulation of follicle cell microvillus length

extracellular structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix assembly [inference]

vitelline membrane formation [inference]

vitelline membrane formation involved in chorion-containing eggshell formation

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix assembly [inference]

vitelline membrane formation [inference]

vitelline membrane formation involved in chorion-containing eggshell formation

reproductive process [inference]

developmental process involved in reproduction [inference]

eggshell formation [inference]

chorion-containing eggshell formation

vitelline membrane formation [inference]

vitelline membrane formation involved in chorion-containing eggshell formation

cellular process involved in reproduction in multicellular organism [inference]

egg coat formation [inference]

vitelline membrane formation [inference]

vitelline membrane formation involved in chorion-containing eggshell formation

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

developmental process [inference]

developmental process involved in reproduction [inference]

eggshell formation [inference]

chorion-containing eggshell formation

vitelline membrane formation [inference]

vitelline membrane formation involved in chorion-containing eggshell formation

anatomical structure morphogenesis [inference]

tube morphogenesis

anatomical structure formation involved in morphogenesis [inference]

cellular component assembly involved in morphogenesis [inference]

vitelline membrane formation [inference]

vitelline membrane formation involved in chorion-containing eggshell formation

eggshell formation [inference]

chorion-containing eggshell formation

response to stimulus [inference]

immune response [inference]

organ or tissue specific immune response [inference]

mucosal immune response

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

apical protein localization

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

apical protein localization

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of clathrin-dependent endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of clathrin-dependent endocytosis

regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of clathrin-dependent endocytosis

regulation of clathrin-dependent endocytosis [inference]

positive regulation of clathrin-dependent endocytosis

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of clathrin-dependent endocytosis

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of clathrin-dependent endocytosis

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of clathrin-dependent endocytosis

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of clathrin-dependent endocytosis

regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of clathrin-dependent endocytosis

regulation of clathrin-dependent endocytosis [inference]

positive regulation of clathrin-dependent endocytosis

regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of microvillus organization [inference]

regulation of follicle cell microvillus organization [inference]

regulation of follicle cell microvillus length

regulation of microvillus length [inference]

regulation of follicle cell microvillus length

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of clathrin-dependent endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of clathrin-dependent endocytosis

regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of clathrin-dependent endocytosis

regulation of clathrin-dependent endocytosis [inference]

positive regulation of clathrin-dependent endocytosis

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of cell size [inference]

regulation of follicle cell microvillus length

regulation of cell projection size [inference]

regulation of microvillus length [inference]

regulation of follicle cell microvillus length

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
brush border membrane	IDA	25639794
endosome membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

endosome membrane

plasma membrane region [inference]

apical plasma membrane

cell projection membrane [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

actin-based cell projection [inference]

microvillus

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

Displaying **all 2** entries
GO Term	Evidence Code	PMID
myosin binding	IPI	25236597
calcium ion binding	IEA ISM	11162110

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

cytoskeletal protein binding [inference]

myosin binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Uncharacterized protein

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 2** entries
Gene Ontology
calcium ion binding
homophilic cell adhesion via plasma membrane adhesion molecules

Displaying **all 3** entries
InterPro
Cadherin conserved site
Cadherin-like superfamily
Cadherin-like

Alliance of Genome Resources

Expression

Displaying **all 4** entries
Location	References
brush border membrane	PMID:25639794
microvillus	PMID:16260500 PMID:16507588
endosome	PMID:25639794
apical plasma membrane	PMID:16507588

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0110481	autosomal recessive nonsyndromic deafness 23	Alliance of Genome Resources
DOID:0110831	Usher syndrome type 1D	Alliance of Genome Resources
DOID:0110832	Usher syndrome type 1F	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 43 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Mus musculus	11994		MGI:1891428
Homo sapiens	65217		HGNC:14674
Caenorhabditis elegans	177671		WB:WBGene00000397
Danio rerio	368476		ZFIN:ZDB-GENE-030616-3
Danio rerio	503521		ZFIN:ZDB-GENE-050214-1
Rattus norvegicus	690865		RGD:1590969
Drosophila pseudoobscura	4800299	7237_1:000cc3
Drosophila ananassae	6501442	7217_1:0006cf
Drosophila yakuba	6537991	7245_1:003217
Drosophila erecta	6554335	7220_0:0000b8