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proprotein convertase subtilisin/kexin type 9

Summary

Gene Symbol

PCSK9

Organism

Pan troglodytes (chimpanzee)

External Links

NCBI Gene: 456880
PubChem: 456880

Annotation

Keyword

Apoptosis
Autocatalytic cleavage
Calcium
Cholesterol metabolism
Cytoplasm
Disulfide bond
Endoplasmic reticulum
Endosome
Glycoprotein
Golgi apparatus
Lysosome
Phosphoprotein
Reference proteome
Secreted
Serine protease
Signal
Sulfation
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
A8T644	Proprotein convertase 9 Subtilisin/kexin-like protease PC9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cholesterol metabolic process
proteolysis	IEA	22301074
regulation of neuron apoptotic process
apoptotic process
low-density lipoprotein particle receptor catabolic process

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

catabolic process [inference]

cellular catabolic process [inference]

receptor catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

receptor catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

receptor catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

protein metabolic process [inference]

proteolysis

protein catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

receptor catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

protein metabolic process [inference]

proteolysis

protein catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

receptor metabolic process [inference]

low-density lipoprotein receptor particle metabolic process [inference]

low-density lipoprotein particle receptor catabolic process

receptor catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

receptor catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process

cellular metabolic process [inference]

cellular catabolic process [inference]

receptor catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of neuron apoptotic process

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
early endosome
Golgi apparatus
late endosome
cell surface
lysosome

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
very-low-density lipoprotein particle binding
low-density lipoprotein particle binding
apolipoprotein binding
serine-type endopeptidase activity	IEA	22301074 30032202

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

binding [inference]

protein binding [inference]

protein-containing complex binding [inference]

protein-lipid complex binding [inference]

lipoprotein particle binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Hominidae

Group Name

proprotein convertase subtilisin/kexin type 9

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones

Displaying entries **1 - 10** of 37 in total

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Gene Ontology
apolipoprotein binding
apolipoprotein receptor binding
cellular response to insulin stimulus
cellular response to starvation
cholesterol metabolic process
hydrolase activity
kidney development
lipid metabolic process
lipoprotein metabolic process
liver development

Displaying **all 9** entries
InterPro
Peptidase S8 propeptide/proteinase inhibitor I9 superfamily
Peptidase S8 propeptide/proteinase inhibitor I9
Peptidase S8, subtilisin-related
Peptidase S8/S53 domain superfamily
Peptidase S8/S53 domain
Proprotein convertase subtilisin/kexin type 9, C-terminal domain 1
Proprotein convertase subtilisin/kexin type 9, C-terminal domain 2
Proprotein convertase subtilisin/kexin type 9, C-terminal domain 3
Proteinase K-like catalytic domain

Ortholog

Displaying entries **1 - 10** of 56 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Mus musculus	100102		MOUSE39533
Homo sapiens	255738	9606_1:000758	HUMAN50078
Rattus norvegicus	298296		RATNO33604
Macaca mulatta	717147		MACMU21438
Danio rerio	100150316		DANRE20382
Taeniopygia guttata	100223154		TAEGU28734
Callithrix jacchus	100395116		CALJA39535
Pongo abelii	100457996	9601_0:000157	PONAB17859
Meleagris gallopavo	100544916		MELGA02462
Anolis carolinensis	100564252		ANOCA06096