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proprotein convertase subtilisin/kexin type 9

Summary

Gene Symbol

PCSK9

Organism

Macaca mulatta (Rhesus monkey)

External Links

NCBI Gene: 717147
PubChem: 717147

Annotation

Keyword

Apoptosis
Autocatalytic cleavage
Calcium
Cholesterol metabolism
Cytoplasm
Disulfide bond
Endoplasmic reticulum
Endosome
Glycoprotein
Golgi apparatus
Lysosome
Phosphoprotein
Reference proteome
Secreted
Serine protease
Signal
Sulfation
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
A8T666	Proprotein convertase 9 Subtilisin/kexin-like protease PC9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
proteolysis	IEA	22301074
apoptotic process
cholesterol metabolic process
low-density lipoprotein particle receptor catabolic process
regulation of neuron apoptotic process

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

catabolic process [inference]

cellular catabolic process [inference]

receptor catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

receptor catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

receptor catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

protein metabolic process [inference]

proteolysis

protein catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

receptor catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

protein metabolic process [inference]

proteolysis

protein catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

receptor metabolic process [inference]

low-density lipoprotein receptor particle metabolic process [inference]

low-density lipoprotein particle receptor catabolic process

receptor catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

receptor catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process

cellular metabolic process [inference]

cellular catabolic process [inference]

receptor catabolic process [inference]

low-density lipoprotein particle receptor catabolic process

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of neuron apoptotic process

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
extracellular space	IEA	30032202
cytoplasm
lysosome
early endosome
late endosome

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
serine-type endopeptidase activity	IEA	22301074 30032202
low-density lipoprotein particle binding
apolipoprotein binding
very-low-density lipoprotein particle binding

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

binding [inference]

protein binding [inference]

protein-containing complex binding [inference]

protein-lipid complex binding [inference]

lipoprotein particle binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

protease

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
hydrolase activity
proteolysis
serine-type endopeptidase activity
serine-type peptidase activity

Displaying **all 6** entries
InterPro
Peptidase S8 propeptide/proteinase inhibitor I9 superfamily
Peptidase S8 propeptide/proteinase inhibitor I9
Peptidase S8, subtilisin, Ser-active site
Peptidase S8, subtilisin-related
Peptidase S8/S53 domain superfamily
Peptidase S8/S53 domain

Ortholog

Displaying entries **1 - 10** of 53 in total

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Species	Gene ID	Orthologous MAtrix
Mus musculus	100102	MOUSE39533
Homo sapiens	255738	HUMAN50078
Rattus norvegicus	298296	RATNO33604
Pan troglodytes	456880	PANTR21203
Danio rerio	100150316	DANRE20382
Taeniopygia guttata	100223154	TAEGU28734
Callithrix jacchus	100395116	CALJA39535
Pongo abelii	100457996	PONAB17859
Meleagris gallopavo	100544916	MELGA02462
Anolis carolinensis	100564252	ANOCA06096