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Guidelines

MIRAGE

opioid receptor kappa 1

Summary

Gene Symbol

OPRK1

Organism

Homo sapiens (human)

External Links

NCBI Gene

4986

PubChem

4986

Alliance of Genome Resources

HGNC:8154

Annotation

Keyword

3D-structure
Alternative splicing
Behavior
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Palmitate
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P41145
A0A5F9ZI09

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **31 - 32** of 32 in total

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GO Term	Evidence Code	PMID
positive regulation of eating behavior	IEA
conditioned place preference	IEA

GO Hierarchy

biological process

immune system process [inference]

immune response

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting opioid receptor signaling pathway

G protein-coupled opioid receptor signaling pathway

adenylate cyclase-inhibiting opioid receptor signaling pathway

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to biotic stimulus [inference]

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

reproductive process [inference]

reproductive behavior [inference]

parental behavior [inference]

maternal behavior

multicellular organismal reproductive process [inference]

ovulation cycle [inference]

estrous cycle

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception

cognition [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

conditioned place preference

behavior [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

conditioned place preference

locomotory behavior

feeding behavior [inference]

eating behavior

reproductive behavior [inference]

parental behavior [inference]

maternal behavior

adult behavior [inference]

behavioral response to cocaine

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular glucose homeostasis [inference]

cellular response to glucose stimulus

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis [inference]

intracellular glucose homeostasis [inference]

cellular response to glucose stimulus

intracellular chemical homeostasis [inference]

intracellular glucose homeostasis [inference]

cellular response to glucose stimulus

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

rhythmic process [inference]

ovulation cycle [inference]

estrous cycle

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

response to other organism [inference]

response to virus [inference]

defense response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

response to other organism [inference]

response to virus [inference]

defense response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

cellular response to biotic stimulus [inference]

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to estrogen

response to chemical [inference]

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to estrogen

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose [inference]

cellular response to glucose stimulus

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to acrylamide

response to lipid [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to organic substance [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to lipid [inference]

cellular response to lipopolysaccharide

response to alcohol [inference]

response to ethanol

response to nicotine

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to acrylamide

response to oxygen-containing compound [inference]

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose [inference]

cellular response to glucose stimulus

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

response to alcohol [inference]

response to ethanol

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

response to acrylamide

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to biotic stimulus [inference]

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

regulation of p38MAPK cascade [inference]

positive regulation of p38MAPK cascade

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

regulation of p38MAPK cascade [inference]

positive regulation of p38MAPK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

negative regulation of signaling [inference]

negative regulation of hormone secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

regulation of hormone secretion [inference]

regulation of gonadotropin secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

regulation of luteinizing hormone secretion [inference]

negative regulation of luteinizing hormone secretion

negative regulation of hormone secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

regulation of monoatomic cation transmembrane transport [inference]

regulation of potassium ion transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of potassium ion transport [inference]

positive regulation of potassium ion transport [inference]

positive regulation of potassium ion transmembrane transport

regulation of potassium ion transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

regulation of monoatomic cation transmembrane transport [inference]

regulation of potassium ion transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

positive regulation of potassium ion transport [inference]

positive regulation of potassium ion transmembrane transport

regulation of secretion [inference]

regulation of saliva secretion

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

regulation of gonadotropin secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

regulation of luteinizing hormone secretion [inference]

negative regulation of luteinizing hormone secretion

negative regulation of hormone secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

regulation of catecholamine secretion [inference]

regulation of dopamine secretion [inference]

positive regulation of dopamine secretion

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

positive regulation of potassium ion transport [inference]

positive regulation of potassium ion transmembrane transport

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

positive regulation of amine transport [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

regulation of amine transport [inference]

regulation of catecholamine secretion [inference]

regulation of dopamine secretion [inference]

positive regulation of dopamine secretion

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

positive regulation of amine transport [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

positive regulation of potassium ion transport [inference]

positive regulation of potassium ion transmembrane transport

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

positive regulation of amine transport [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

positive regulation of multicellular organismal process [inference]

positive regulation of behavior [inference]

positive regulation of feeding behavior [inference]

positive regulation of eating behavior

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of hormone secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of hormone secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

negative regulation of multicellular organismal process [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

regulation of p38MAPK cascade [inference]

positive regulation of p38MAPK cascade

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

regulation of p38MAPK cascade [inference]

positive regulation of p38MAPK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

regulation of p38MAPK cascade [inference]

positive regulation of p38MAPK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting opioid receptor signaling pathway

G protein-coupled opioid receptor signaling pathway

adenylate cyclase-inhibiting opioid receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

regulation of p38MAPK cascade [inference]

positive regulation of p38MAPK cascade

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

regulation of p38MAPK cascade [inference]

positive regulation of p38MAPK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

negative regulation of cell communication [inference]

negative regulation of hormone secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

regulation of hormone secretion [inference]

regulation of gonadotropin secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

regulation of luteinizing hormone secretion [inference]

negative regulation of luteinizing hormone secretion

negative regulation of hormone secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

regulation of transmembrane transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

regulation of monoatomic cation transmembrane transport [inference]

regulation of potassium ion transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of potassium ion transmembrane transport

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of hormone secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

regulation of cellular response to stress [inference]

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

regulation of p38MAPK cascade [inference]

positive regulation of p38MAPK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of p38MAPK cascade

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

regulation of gonadotropin secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

regulation of luteinizing hormone secretion [inference]

negative regulation of luteinizing hormone secretion

negative regulation of hormone secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

regulation of catecholamine secretion [inference]

regulation of dopamine secretion [inference]

positive regulation of dopamine secretion

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of digestive system process [inference]

regulation of saliva secretion

regulation of endocrine process [inference]

regulation of gonadotropin secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

regulation of luteinizing hormone secretion [inference]

negative regulation of luteinizing hormone secretion

regulation of behavior [inference]

positive regulation of behavior [inference]

positive regulation of feeding behavior [inference]

positive regulation of eating behavior

regulation of feeding behavior [inference]

regulation of eating behavior [inference]

positive regulation of eating behavior

positive regulation of feeding behavior [inference]

positive regulation of eating behavior

positive regulation of multicellular organismal process [inference]

positive regulation of behavior [inference]

positive regulation of feeding behavior [inference]

positive regulation of eating behavior

negative regulation of multicellular organismal process [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

regulation of biological quality [inference]

regulation of hormone levels [inference]

regulation of hormone secretion [inference]

regulation of gonadotropin secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

regulation of luteinizing hormone secretion [inference]

negative regulation of luteinizing hormone secretion

negative regulation of hormone secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

regulation of body fluid levels [inference]

regulation of saliva secretion

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
nucleoplasm	IDA
mitochondrion	IEA
cytosol	IDA
plasma membrane	TAS
plasma membrane	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

bounding membrane of organelle [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

plasma membrane region [inference]

synaptic membrane [inference]

T-tubule

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

dendrite

perikaryon

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

endoplasmic reticulum [inference]

sarcoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

endoplasmic reticulum [inference]

sarcoplasmic reticulum

neuron projection terminus [inference]

axon terminus

presynapse [inference]

axon terminus

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
G protein-coupled opioid receptor activity	IDA	22437504
protein binding	IPI	16431922 22200678 31668922 32296183
receptor serine/threonine kinase binding	IEA
dynorphin receptor activity	IDA	8755601
dynorphin receptor activity	IMP	7624359

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

receptor serine/threonine kinase binding

amide binding [inference]

peptide binding [inference]

neuropeptide binding

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

dynorphin receptor activity

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled opioid receptor activity

dynorphin receptor activity

G protein-coupled peptide receptor activity [inference]

dynorphin receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

receptor

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
neuropeptide binding
neuropeptide signaling pathway

Displaying **all 2** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Disease

Disease Ontology

Displaying **all 8** entries
DO ID	Disease Name	Source
DOID:0050741	alcohol dependence	Alliance of Genome Resources
DOID:11206	opioid abuse	Alliance of Genome Resources
DOID:1574	alcohol use disorder	Alliance of Genome Resources
DOID:1596	depressive disorder	Alliance of Genome Resources
DOID:2559	opiate dependence	Alliance of Genome Resources
DOID:9828	neonatal abstinence syndrome	Alliance of Genome Resources
DOID:9975	cocaine dependence	Alliance of Genome Resources
DOID:9976	heroin dependence	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of **132** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	24613	FB:FBgn0036789
Drosophila melanogaster	25033	FB:FBgn0036789
Drosophila melanogaster	25555	FB:FBgn0036789
Drosophila melanogaster	25601	FB:FBgn0036789
Caenorhabditis elegans	29256	WB:WBGene00020086
Rattus norvegicus	29335	Xenbase:XB-GENE-1011503	RATNO34724
Drosophila melanogaster	54305	FB:FBgn0036789
Caenorhabditis elegans	83567	WB:WBGene00020086
Drosophila melanogaster	171044	FB:FBgn0036789
Caenorhabditis elegans	226304	WB:WBGene00020086

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Last updated: April 7, 2025