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SNF2 related chromatin remodeling annealing helicase 1

Summary

Gene Symbol

SMARCAL1

Organism

Homo sapiens (human)

External Links

NCBI Gene

50485

PubChem

50485

Alliance of Genome Resources

HGNC:11102

Annotation

Keyword

3D-structure
Acetylation
Coiled coil
Disease variant
Helicase
Nucleus
Phosphoprotein
Reference proteome
Repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NZC9	HepA-related protein Sucrose nonfermenting protein 2-like 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
replication fork processing	IBA IMP TAS	19793862 27918544
DNA repair	IBA
regulation of transcription by RNA polymerase II	IMP	18974355
t-circle formation	TAS	27918544
DNA damage response	IMP	19793862

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

Displaying **all 5** entries
GO Term	Evidence Code	PMID
site of double-strand break	IDA	19793862 19793863
nucleoplasm	IDA
nuclear replication fork	IBA
nucleus	IDA	18974355
DNA replication factor A complex	IDA	19793862 19793863

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

DNA replication factor A complex

cellular anatomical entity [inference]

nucleoplasm

replication fork [inference]

nuclear replication fork

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

site of DNA damage [inference]

site of double-strand break

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	19793862 19793863 24126761 24910198 24981860
ATP-dependent chromatin remodeler activity	IEA
hydrolase activity	IEA
helicase activity	IEA
ATP-dependent DNA/DNA annealing activity	IDA IMP	18974355 22705370

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

catalytic activity, acting on a nucleic acid [inference]

helicase activity

catalytic activity, acting on DNA [inference]

ATP-dependent activity, acting on DNA [inference]

ATP-dependent chromatin remodeler activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

single-stranded DNA binding [inference]

DNA/DNA annealing activity [inference]

ATP-dependent DNA/DNA annealing activity

annealing activity [inference]

DNA/DNA annealing activity [inference]

ATP-dependent DNA/DNA annealing activity

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

helicase activity

ATP-dependent activity, acting on DNA [inference]

ATP-dependent chromatin remodeler activity

ATP-dependent DNA/DNA annealing activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Helicase

Functional Category

I: Lipid transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
ATP binding
DNA repair
hydrolase activity
nucleotide binding

Displaying **all 6** entries
InterPro
Helicase superfamily 1/2, ATP-binding domain
Helicase, C-terminal domain-like
P-loop containing nucleoside triphosphate hydrolase
SNF2, N-terminal
SNF2-like, N-terminal domain superfamily
SNF2/RAD5-like, C-terminal helicase domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060490	Schimke immuno-osseous dysplasia	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 97 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Oreochromis niloticus	100709977		ORENI23528
Cavia porcellus	100724981		CAVPO23866
Cricetulus griseus	100754301		CRIGR05526
Otolemur garnettii	100946592		OTOGA16073
Pan paniscus	100971581	9597_0:000c79	PANPA26624
Papio anubis	101010283		PAPAN02393
Saimiri boliviensis boliviensis	101042562		SAIBB09466
Takifugu rubripes	101062074		TAKRU25363
Felis catus	101083787		FELCA21544
Ovis aries	101107765		SHEEP09734

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements