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thioredoxin reductase 1

Summary

Gene Symbol

Txnrd1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

50493

PubChem

50493

Alliance of Genome Resources

MGI:1354175

Annotation

Keyword

Alternative splicing
Cytoplasm
Disulfide bond
FAD
NADP
Oxidoreductase
Phosphoprotein
Redox-active center
Reference proteome
Selenocysteine
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9JMH6	Peroxidase TXNRD1 Thioredoxin reductase TR1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
selenocysteine metabolic process	ISO
hydrogen peroxide catabolic process	ISO
cellular oxidant detoxification	IEA
cell redox homeostasis	IBA IEA
NADPH oxidation	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

serine family amino acid metabolic process [inference]

selenocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

catabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

serine family amino acid metabolic process [inference]

selenocysteine metabolic process

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

benzene-containing compound metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

cellular catabolic process [inference]

hydrogen peroxide catabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

reactive oxygen species metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

serine family amino acid metabolic process [inference]

selenocysteine metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

serine family amino acid metabolic process [inference]

selenocysteine metabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

serine family amino acid metabolic process [inference]

selenocysteine metabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

benzene-containing compound metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

serine family amino acid metabolic process [inference]

selenocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

cellular process [inference]

cell population proliferation

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

serine family amino acid metabolic process [inference]

selenocysteine metabolic process

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

benzene-containing compound metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

cellular catabolic process [inference]

hydrogen peroxide catabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH oxidation

reactive oxygen species metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

cellular detoxification [inference]

cellular oxidant detoxification

developmental process [inference]

anatomical structure morphogenesis [inference]

embryonic morphogenesis [inference]

gastrulation

anatomical structure formation involved in morphogenesis [inference]

formation of primary germ layer [inference]

mesoderm formation

homeostatic process [inference]

cellular homeostasis [inference]

cell redox homeostasis

response to stimulus [inference]

response to stress [inference]

response to oxidative stress

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
nucleus	IDA	10721726
cytoplasm	IBA IDA	10721726
nucleoplasm	IEA ISO
cytosol	IBA IDA	11259642
neuronal cell body	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

cell body [inference]

neuronal cell body

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
selenate reductase activity	ISO
NADPH peroxidase activity	ISO ISS
thioredoxin-disulfide reductase (NADP) activity	IBA IDA ISO	11259642
NAD(P)H oxidase H2O2-forming activity	ISO
mercury ion binding	ISO