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solute carrier family 3 member 2

Summary

Gene Symbol

Slc3a2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

50567

PubChem

50567

Alliance of Genome Resources

RGD:3073

Annotation

Keyword

Amino-acid transport
Cell junction
Cell membrane
Disulfide bond
Glycoprotein
Isopeptide bond
Lysosome
Phosphoprotein
Reference proteome
Signal-anchor
Transmembrane helix
Ubl conjugation

Proteins

Displaying **all 4** entries
UniProt	Protein Name
A6HZS2
A0A0H2UHQ0
Q794F9	4F2 cell-surface antigen heavy chain Solute carrier family 3 member 2
A6HZS0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
tyrosine transport	IEA ISO
leucine transport	IDA ISO	10049700 9726963
tryptophan transport	IDA IEA ISO ISS	10049700 12614332
neutral amino acid transport	IMP	9726963
L-histidine transport	IDA IEA ISO	10049700

GO Hierarchy

biological process

metabolic process [inference]

primary metabolic process [inference]

carbohydrate metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process

cellular process [inference]

cell communication [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

transmembrane transport [inference]

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

leucine import across plasma membrane [inference]

L-leucine import across plasma membrane

L-alanine import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane [inference]

leucine import across plasma membrane [inference]

L-leucine import across plasma membrane

L-alanine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-leucine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

movement in host [inference]

entry into host [inference]

viral entry into host cell

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

response to starvation [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

response to starvation [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

response to activity [inference]

response to muscle activity

response to chemical [inference]

response to organic substance [inference]

response to organic cyclic compound [inference]

response to dsRNA [inference]

response to exogenous dsRNA

response to nitrogen compound [inference]

response to dsRNA [inference]

response to exogenous dsRNA

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

localization [inference]

establishment of localization [inference]

transport [inference]

hormone transport [inference]

thyroid hormone transport

transmembrane transport [inference]

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

leucine import across plasma membrane [inference]

L-leucine import across plasma membrane

L-alanine import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane [inference]

leucine import across plasma membrane [inference]

L-leucine import across plasma membrane

L-alanine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-leucine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

organic substance transport [inference]

organic anion transport [inference]

carboxylic acid transport [inference]

amino acid transport [inference]

sulfur amino acid transport [inference]

methionine transport

amino acid transmembrane transport [inference]

amino acid import across plasma membrane [inference]

leucine import across plasma membrane [inference]

L-leucine import across plasma membrane

L-alanine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-leucine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

aromatic amino acid transport [inference]

basic amino acid transport [inference]

histidine transport [inference]

L-histidine transport

branched-chain amino acid transport [inference]

isoleucine transport

leucine transport

leucine import across plasma membrane [inference]

L-leucine import across plasma membrane

valine transport

neutral amino acid transport

isoleucine transport

leucine transport

leucine import across plasma membrane [inference]

L-leucine import across plasma membrane

alanine transport [inference]

L-alanine transport [inference]

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

L-amino acid transport [inference]

L-alanine transport [inference]

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

L-histidine transport

L-alpha-amino acid transmembrane transport [inference]

L-leucine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

phenylalanine transport

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane [inference]

leucine import across plasma membrane [inference]

L-leucine import across plasma membrane

L-alanine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-leucine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

organic acid transport [inference]

carboxylic acid transport [inference]

amino acid transport [inference]

sulfur amino acid transport [inference]

methionine transport

amino acid transmembrane transport [inference]

amino acid import across plasma membrane [inference]

leucine import across plasma membrane [inference]

L-leucine import across plasma membrane

L-alanine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-leucine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

aromatic amino acid transport [inference]

basic amino acid transport [inference]

histidine transport [inference]

L-histidine transport

branched-chain amino acid transport [inference]

isoleucine transport

leucine transport

leucine import across plasma membrane [inference]

L-leucine import across plasma membrane

valine transport

neutral amino acid transport

isoleucine transport

leucine transport

leucine import across plasma membrane [inference]

L-leucine import across plasma membrane

alanine transport [inference]

L-alanine transport [inference]

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

L-amino acid transport [inference]

L-alanine transport [inference]

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

L-histidine transport

L-alpha-amino acid transmembrane transport [inference]

L-leucine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

phenylalanine transport

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane [inference]

leucine import across plasma membrane [inference]

L-leucine import across plasma membrane

L-alanine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-leucine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane [inference]

leucine import across plasma membrane [inference]

L-leucine import across plasma membrane

L-alanine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-leucine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

nitrogen compound transport [inference]

amino acid transport [inference]

sulfur amino acid transport [inference]

methionine transport

amino acid transmembrane transport [inference]

amino acid import across plasma membrane [inference]

leucine import across plasma membrane [inference]

L-leucine import across plasma membrane

L-alanine import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-leucine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

aromatic amino acid transport [inference]

basic amino acid transport [inference]

histidine transport [inference]

L-histidine transport

branched-chain amino acid transport [inference]

isoleucine transport

leucine transport

leucine import across plasma membrane [inference]

L-leucine import across plasma membrane

valine transport

neutral amino acid transport

isoleucine transport

leucine transport

leucine import across plasma membrane [inference]

L-leucine import across plasma membrane

alanine transport [inference]

L-alanine transport [inference]

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

L-amino acid transport [inference]

L-alanine transport [inference]

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

L-histidine transport

L-alpha-amino acid transmembrane transport [inference]

L-leucine import across plasma membrane

L-alanine transmembrane transport [inference]

L-alanine import across plasma membrane

phenylalanine transport

sulfur compound transport [inference]

sulfur amino acid transport [inference]

methionine transport

import into cell [inference]

amino acid import across plasma membrane [inference]

leucine import across plasma membrane [inference]

L-leucine import across plasma membrane

L-alanine import across plasma membrane

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone transport [inference]

thyroid hormone transport

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
membrane	IC	9480885
anchoring junction	IEA
apical plasma membrane	IBA IDA IEA ISO	11095508
neuronal cell body	ISO
plasma membrane	ISO ISS

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

amino acid transport complex

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

plasma membrane region [inference]

cell junction [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

cell body [inference]

neuronal cell body

cell pole [inference]

apical pole of neuron

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
exogenous protein binding	IEA ISO
L-leucine transmembrane transporter activity	IBA IEA ISO
double-stranded RNA binding	IEA ISO
protein heterodimerization activity	IEA ISO
aromatic amino acid transmembrane transporter activity	IBA IEA ISO

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

organic acid transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity [inference]

aromatic amino acid transmembrane transporter activity

neutral L-amino acid transmembrane transporter activity

alanine transmembrane transporter activity [inference]

L-alanine transmembrane transporter activity

L-amino acid transmembrane transporter activity [inference]

branched-chain amino acid transmembrane transporter activity [inference]

L-leucine transmembrane transporter activity

organic anion transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity [inference]

aromatic amino acid transmembrane transporter activity

neutral L-amino acid transmembrane transporter activity

alanine transmembrane transporter activity [inference]

L-alanine transmembrane transporter activity

L-amino acid transmembrane transporter activity [inference]

branched-chain amino acid transmembrane transporter activity [inference]

L-leucine transmembrane transporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

neutral L-amino acid secondary active transmembrane transporter activity

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

exogenous protein binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

double-stranded RNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

4F2 cell-surface antigen heavy chain

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
L-alanine import across plasma membrane
L-alanine transmembrane transporter activity
L-leucine transmembrane transporter activity
aromatic amino acid transmembrane transporter activity
phenylalanine transport

Displaying **all 5** entries
InterPro
Amino acid transporter heavy chain SLC3A2
Glycoside hydrolase superfamily
Glycosyl hydrolase, all-beta
Glycosyl hydrolase, family 13, catalytic domain
Solute carrier family 3 member 2, N-terminal domain

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:0050865	tongue squamous cell carcinoma	Alliance of Genome Resources
DOID:0080202	adenoid cystic carcinoma	Alliance of Genome Resources
DOID:0080899	lung pleomorphic carcinoma	Alliance of Genome Resources
DOID:2671	transitional cell carcinoma	Alliance of Genome Resources
DOID:3908	lung non-small cell carcinoma	Alliance of Genome Resources
DOID:3910	lung adenocarcinoma	Alliance of Genome Resources
DOID:5517	stomach carcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of **112** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Ovis aries	101116778		SHEEP11097
Gorilla gorilla gorilla	101128892		GORGO02117
Oryzias latipes	101170465		ORYLA07365
Octodon degus	101571043	10160_0:0049b3	OCTDE25302
Jaculus jaculus	101593398	51337_0:0001ea
Mustela putorius furo	101682175		MUSPF05804
Heterocephalus glaber	101701746	10181_0:004c31
Mesocricetus auratus	101832315	10036_0:0002ba
Chrysemys picta bellii	101937381		CHRPI08861
Ictidomys tridecemlineatus	101959540	43179_0:001987

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements