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protein-L-isoaspartate (D-aspartate) O-methyltransferase

Summary

Gene Symbol

PCMT1

Organism

Homo sapiens (human)

External Links

NCBI Gene

5110

PubChem

5110

Alliance of Genome Resources

HGNC:8728

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cytoplasm
Direct protein sequencing
Methyltransferase
Proteomics identification
Reference proteome
S-adenosyl-L-methionine

Proteins

Displaying **all 4** entries
UniProt	Protein Name
F6S8N6	L-isoaspartyl protein carboxyl methyltransferase Protein L-isoaspartyl/D-aspartyl methyltransferase Protein-beta-aspartate methyltransferase
B7Z972
A0A3F2YNX8
P22061	L-isoaspartyl protein carboxyl methyltransferase Protein L-isoaspartyl/D-aspartyl methyltransferase Protein-beta-aspartate methyltransferase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein methylation	IDA	3167043
protein repair	TAS	8074695

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein repair

protein modification process [inference]

protein alkylation [inference]

protein methylation

methylation [inference]

macromolecule methylation [inference]

protein methylation

primary metabolic process [inference]

protein metabolic process [inference]

protein repair

protein modification process [inference]

protein alkylation [inference]

protein methylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein repair

protein modification process [inference]

protein alkylation [inference]

protein methylation

macromolecule modification [inference]

protein modification process [inference]

protein alkylation [inference]

protein methylation

macromolecule methylation [inference]

protein methylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein repair

protein modification process [inference]

protein alkylation [inference]

protein methylation

Displaying **all 4** entries
GO Term	Evidence Code	PMID
extracellular vesicle	HDA	24769233
cytosol	IDA TAS
cytoplasm	IBA
extracellular exosome	HDA	23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle

extracellular exosome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	25416956 28514442 32296183 32814053 32838362 33961781 34232536
protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	IBA IDA TAS	3167043 8074695
cadherin binding	HDA	25468996

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring one-carbon groups [inference]

methyltransferase activity [inference]

O-methyltransferase activity [inference]

carboxyl-O-methyltransferase activity [inference]

protein carboxyl O-methyltransferase activity [inference]

protein-L-isoaspartate (D-aspartate) O-methyltransferase activity

protein methyltransferase activity [inference]

protein carboxyl O-methyltransferase activity [inference]

protein-L-isoaspartate (D-aspartate) O-methyltransferase activity

S-adenosylmethionine-dependent methyltransferase activity [inference]

protein-L-isoaspartate (D-aspartate) O-methyltransferase activity

catalytic activity, acting on a protein [inference]

protein methyltransferase activity [inference]

protein carboxyl O-methyltransferase activity [inference]

protein-L-isoaspartate (D-aspartate) O-methyltransferase activity

binding [inference]

protein binding

cell adhesion molecule binding [inference]

cadherin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE

Functional Category

I: Lipid transport and metabolism
K: Transcription
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 3** entries
Gene Ontology
methylation
protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
transferase activity

Displaying **all 2** entries
InterPro
Protein-L-isoaspartate(D-aspartate) O-methyltransferase
S-adenosyl-L-methionine-dependent methyltransferase superfamily

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:3069	malignant astrocytoma	Alliance of Genome Resources
DOID:3070	high grade glioma	Alliance of Genome Resources

Ortholog

Displaying entries **61 - 67** of 67 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Petromyzon marinus	116948428		PETMA04081
Rhinolophus ferrumequinum	117018972		RHIFE11442
Scophthalmus maximus	118289842		SCOMX17865
Balaenoptera musculus	118905332		BALMU26991
Panthera leo	122220486		PANLE16379
Ursus americanus	123797439		URSAM25890
Pongo pygmaeus	129038680	9600_0:001a4f

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements