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alpha-1,4-N-acetylglucosaminyltransferase

Summary

Gene Symbol

A4GNT

Aliases

alpha4GnT

Organism

Homo sapiens (human)

External Links

NCBI Gene

51146

GGDB ID

gg124

HGNC

17968

mRNA

NM_016161

map

3p14.3

Protein

NP_057245

OMIM

616709

KEGG Gene ID

hsa:51146

PubChem

51146

Alliance of Genome Resources

HGNC:17968

Annotation

Keyword

Glycoprotein
Glycosyltransferase
Golgi apparatus
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9UNA3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein O-linked glycosylation	IBA
epithelial cell proliferation	IEA
glycoprotein biosynthetic process	IDA	10430883
O-glycan processing	TAS
carbohydrate metabolic process	TAS	10430883

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

organonitrogen compound biosynthetic process [inference]

glycoprotein biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process

organonitrogen compound biosynthetic process [inference]

glycoprotein biosynthetic process

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

organic substance metabolic process [inference]

carbohydrate metabolic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

organonitrogen compound biosynthetic process [inference]

glycoprotein biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process

organonitrogen compound biosynthetic process [inference]

glycoprotein biosynthetic process

cellular process [inference]

cell population proliferation [inference]

epithelial cell proliferation

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation

regulation of cellular process [inference]

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation

regulation of epithelial cell proliferation [inference]

negative regulation of epithelial cell proliferation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation

Displaying **all 2** entries
GO Term	Evidence Code	PMID
membrane	TAS	10430883
Golgi membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

Displaying 1 entry
GO Term	Evidence Code	PMID
acetylglucosaminyltransferase activity	IBA IDA TAS	10430883

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

acetylglucosaminyltransferase activity

hexosyltransferase activity [inference]

acetylglucosaminyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

lariat debranching enzyme

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
RNA lariat debranching enzyme activity
hydrolase activity, acting on ester bonds
hydrolase activity
mRNA processing
metal ion binding

Displaying **all 4** entries
InterPro
Calcineurin-like phosphoesterase domain, ApaH type
Lariat debranching enzyme, C-terminal
Lariat debranching enzyme, N-terminal metallophosphatase domain
Metallo-dependent phosphatase-like

GlycoGene Database (GGDB)

GGDB ID

gg124

Gene Symbol

A4GNT

Reactions

Displaying 1 entry
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
(not applicable)	G65889KE	R	G94473FP	R	10430883

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Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
(not applicable)	G65889KE	R	G94473FP	R	10430883
UDP-GlcNAc	G10400UC	[beta]pNP	G44375VE	[beta]pNP	10430883
UDP-GlcNAc	G64973KT	[alpha]pNP	G34764BK	[alpha]pNP	10430883
UDP-GlcNAc	G00033MO	[alpha]pNP	G27523II	[alpha]pNP	10430883
UDP-GlcNAc	G39890DX	[alpha]pNP	G34764BK	[alpha]pNP	10430883

Displaying **all 4** entries
Donor	Acceptor	Reducing terminal(Acceptor)	Reference
UDP-GlcNAc	G65889KE	[alpha]pNP	10430883
UDP-GlcNAc	G65889KE	[beta]pNP	10430883
UDP-GlcNAc	G00035MO	pNP	10430883
UDP-GlcNAc	G57321FI	[alpha]pNP	10430883

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Rattus norvegicus	XP_236601	XM_236601
Mus musculus	XP_286168	XM_286168

KEGG BRITE Database

Orthology

K08251

Name

alpha 1,4-N-acetylglucosaminyltransferase [EC:2.4.1.-]

References

10430883

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R07131	2.4.1.-	G09938IH	G05724WC

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:1793	pancreatic cancer	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 50** of 70 in total

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Species	Gene ID	Orthologous MAtrix
Capra hircus	102187991	CAPHI12561
Latimeria chalumnae	102365494	LATCH12770
Callorhinchus milii	103190151	CALMI00793
Callorhinchus milii	103190220	CALMI00794
Chlorocebus sabaeus	103241608	CHLSB04854
Carlito syrichta	103250691	CARSF25291
Ursus maritimus	103678717	URSMA01756
Nannospalax galili	103737606	NANGA25538
Rhinopithecus roxellana	104662298	RHIRO35473
Pteropus vampyrus	105300831	PTEVA10521

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

GlycoGene Database (GGDB)

KEGG BRITE Database

International Collaboration

Acknowledgements