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glucosaminyl (N-acetyl) transferase 4

Summary

Gene Symbol

GCNT4

Aliases

C2GNT3
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4
core 2 beta-1,6-N-acetylglucosaminyltransferase 3

Organism

Homo sapiens (human)

External Links

NCBI Gene

51301

GGDB ID

gg110

HGNC

17973

mRNA

NM_016591

map

5q12

Protein

NP_057675

OMIM

616782

KEGG Gene ID

hsa:51301

PubChem

51301

Alliance of Genome Resources

HGNC:17973

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
neutrophil homeostasis	IEA
inter-male aggressive behavior	IEA
carbohydrate metabolic process	TAS	10753916
protein O-linked glycosylation	TAS	10753916
O-glycan processing	TAS

GO Hierarchy

biological process

immune system process [inference]

leukocyte homeostasis [inference]

neutrophil homeostasis

myeloid cell homeostasis [inference]

neutrophil homeostasis

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

hormone metabolic process [inference]

thyroid hormone metabolic process

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process

primary metabolic process [inference]

carbohydrate metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

organic substance metabolic process [inference]

carbohydrate metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

organic cyclic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

organic hydroxy compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process

multicellular organismal process [inference]

behavior [inference]

aggressive behavior [inference]

inter-male aggressive behavior

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

leukocyte homeostasis [inference]

neutrophil homeostasis

myeloid cell homeostasis [inference]

neutrophil homeostasis

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

kidney morphogenesis

tissue morphogenesis

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

leukocyte homeostasis [inference]

neutrophil homeostasis

myeloid cell homeostasis [inference]

neutrophil homeostasis

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

thyroid hormone metabolic process

Displaying 1 entry
GO Term	Evidence Code	PMID
Golgi membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity	TAS
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity	TAS	10753916
acetylglucosaminyltransferase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

acetylglucosaminyltransferase activity

hexosyltransferase activity [inference]

acetylglucosaminyltransferase activity

catalytic activity, acting on a protein [inference]

catalytic activity, acting on a glycoprotein [inference]

beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

beta-1,3-galactosyl-o-glycosyl-glycoprotein beta-1,6-n-acetylglucosaminyltransferase

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
transferase activity

Human Protein Atlas

ENSG00000176928

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg110

Gene Symbol

GCNT4

Reactions

Displaying 1 entry
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
UDP-GlcNAc	G00031MO	Ser/Thr	G00033MO	Ser/Thr	10753916

Displaying **all 5** entries
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
UDP-GlcNAc	G00031MO	[alpha]-1-methylumbelliferyl	G00033MO	[alpha]-1-methylumbelliferyl	10753916
UDP-GlcNAc	G00031MO	[alpha]-1-p-nitrophenyl	G00033MO	[alpha]-1-p-nitrophenyl	10753916
UDP-GlcNAc	G00031MO	Ser/Thr	G00033MO	Ser/Thr	10753916
UDP-GlcNAc	G00031MO	[alpha]	G00033MO	[alpha]	10753916
UDP-GlcNAc	G00031MO	[alpha]-1-benzyl	G00033MO	[alpha]-1-benzyl	10753916

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Donor	Acceptor	Reducing terminal(Acceptor)	Reference
UDP-GlcNAc	G00049MO	Cer	10753916
UDP-GlcNAc	G57321FI		10753916
UDP-GlcNAc	G33476GF	[beta]-1-methyl	10753916
UDP-GlcNAc	G00035MO	[alpha]-1-p-nitrophenyl	10753916
UDP-GlcNAc	G58896AZ	Cer	10753916

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Rattus norvegicus	XP_226703	XM_226703
Mus musculus	XP_138797	XM_138797

KEGG BRITE Database

Orthology

K09663

Name

beta-1,6-N-acetylglucosaminyltransferase 4 [EC:2.4.1.-]

References

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R05912	2.4.1.102	G00031MO	G00033MO

Ortholog

Displaying entries **31 - 40** of 91 in total

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Species	Gene ID	Orthologous MAtrix
Sus scrofa	100518180	PIGXX19258
Nomascus leucogenys	100596756	NOMLE13904
Cavia porcellus	100728182	CAVPO24783
Cricetulus griseus	100757239	CRIGR17417
Otolemur garnettii	100964852	OTOGA15245
Saimiri boliviensis boliviensis	101035617	SAIBB01853
Felis catus	101081604	FELCA00356
Ovis aries	101104496	SHEEP17700
Gorilla gorilla gorilla	101136247	GORGO13325
Tursiops truncatus	101330893	TURTR05546

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Summary

External Links

OrthoDB (Group)

GlycoGene Database (GGDB)

KEGG BRITE Database

International Collaboration

Acknowledgements