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programmed cell death 1

Summary

Gene Symbol

PDCD1

Organism

Homo sapiens (human)

External Links

NCBI Gene

5133

PubChem

5133

Alliance of Genome Resources

HGNC:8760

JoGo

PDCD1

TogoVar

PDCD1

Annotation

Keyword

3D-structure
Adaptive immunity
Apoptosis
Cell membrane
Disulfide bond
Glycoprotein
Immunoglobulin domain
Isopeptide bond
Phosphoprotein
Proteomics identification
Reference proteome
Signal
Transmembrane helix
Ubl conjugation

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A0M3M0G7
Q15116
A0ABB0MVI3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
B cell apoptotic process	IEA
adaptive immune response	IEA
negative regulation of tolerance induction	IEA
negative regulation of T cell mediated immune response to tumor cell	IDA	38377992
negative regulation of B cell apoptotic process	IEA

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process

leukocyte apoptotic process [inference]

lymphocyte apoptotic process [inference]

B cell apoptotic process

T cell apoptotic process [inference]

regulatory T cell apoptotic process

response to stimulus [inference]

immune response [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of tolerance induction [inference]

negative regulation of tolerance induction

negative regulation of immune system process [inference]

negative regulation of tolerance induction

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

negative regulation of immune effector process [inference]

negative regulation of leukocyte mediated immunity [inference]

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

negative regulation of T cell activation

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

regulation of immune effector process [inference]

negative regulation of immune effector process [inference]

negative regulation of leukocyte mediated immunity [inference]

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of leukocyte mediated immunity [inference]

negative regulation of leukocyte mediated immunity [inference]

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of lymphocyte mediated immunity [inference]

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of immune response

regulation of adaptive immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of immune response to tumor cell [inference]

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of leukocyte apoptotic process [inference]

positive regulation of lymphocyte apoptotic process [inference]

positive regulation of T cell apoptotic process

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of tolerance induction

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

negative regulation of immune effector process [inference]

negative regulation of leukocyte mediated immunity [inference]

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of leukocyte apoptotic process [inference]

negative regulation of lymphocyte apoptotic process [inference]

negative regulation of B cell apoptotic process

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of response to tumor cell [inference]

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of developmental process [inference]

negative regulation of tolerance induction

negative regulation of multicellular organismal process [inference]

negative regulation of tolerance induction

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of response to tumor cell [inference]

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of response to tumor cell [inference]

negative regulation of response to tumor cell [inference]

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of immune response to tumor cell [inference]

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of response to tumor cell [inference]

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of immune response

regulation of adaptive immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of immune response to tumor cell [inference]

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of developmental process [inference]

negative regulation of developmental process [inference]

negative regulation of tolerance induction

regulation of cellular process [inference]

regulation of cell adhesion [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation

regulation of cell-cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation

regulation of leukocyte cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of leukocyte apoptotic process [inference]

positive regulation of lymphocyte apoptotic process [inference]

positive regulation of T cell apoptotic process

negative regulation of apoptotic process [inference]

negative regulation of leukocyte apoptotic process [inference]

negative regulation of lymphocyte apoptotic process [inference]

negative regulation of B cell apoptotic process

regulation of leukocyte apoptotic process [inference]

regulation of lymphocyte apoptotic process [inference]

regulation of B cell apoptotic process [inference]

negative regulation of B cell apoptotic process

negative regulation of lymphocyte apoptotic process [inference]

negative regulation of B cell apoptotic process

positive regulation of lymphocyte apoptotic process [inference]

positive regulation of T cell apoptotic process

regulation of T cell apoptotic process [inference]

positive regulation of T cell apoptotic process

negative regulation of leukocyte apoptotic process [inference]

negative regulation of lymphocyte apoptotic process [inference]

negative regulation of B cell apoptotic process

positive regulation of leukocyte apoptotic process [inference]

positive regulation of lymphocyte apoptotic process [inference]

positive regulation of T cell apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of leukocyte apoptotic process [inference]

positive regulation of lymphocyte apoptotic process [inference]

positive regulation of T cell apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of leukocyte apoptotic process [inference]

negative regulation of lymphocyte apoptotic process [inference]

negative regulation of B cell apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of leukocyte apoptotic process [inference]

positive regulation of lymphocyte apoptotic process [inference]

positive regulation of T cell apoptotic process

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of leukocyte apoptotic process [inference]

negative regulation of lymphocyte apoptotic process [inference]

negative regulation of B cell apoptotic process

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

negative regulation of T cell activation

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

negative regulation of T cell activation

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

negative regulation of multicellular organismal process [inference]

negative regulation of tolerance induction

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

Displaying **all 3** entries
GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IDA	30487606
external side of plasma membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

side of membrane [inference]

external side of plasma membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	15240681 17489864 20587542 21982860 23417675 26602187 28046066 30487606
signaling receptor activity	IDA	21276005 38377992

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

programmed cell death protein 1

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
V: Defense mechanisms

Displaying **all 3** entries
Gene Ontology
negative regulation of immune response
positive regulation of T cell apoptotic process
regulation of immune response

Displaying **all 6** entries
InterPro
Immunoglobulin V-set domain
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold
Programmed cell death protein 1

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:0080162	lupus nephritis	Alliance of Genome Resources
DOID:1883	hepatitis C	Alliance of Genome Resources
DOID:2043	hepatitis B	Alliance of Genome Resources
DOID:2048	autoimmune hepatitis	Alliance of Genome Resources
DOID:2377	multiple sclerosis	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources
DOID:9074	systemic lupus erythematosus	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements