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programmed cell death 1

Summary

Gene Symbol

PDCD1

Organism

Homo sapiens (human)

External Links

NCBI Gene

5133

PubChem

5133

Alliance of Genome Resources

HGNC:8760

Annotation

Keyword

3D-structure
Adaptive immunity
Apoptosis
Cell membrane
Disulfide bond
Glycoprotein
Immunoglobulin domain
Isopeptide bond
Phosphoprotein
Reference proteome
Signal
Systemic lupus erythematosus
Transmembrane helix
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q15116
A0A0M3M0G7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
B cell apoptotic process	IEA
adaptive immune response	IEA
negative regulation of tolerance induction	IEA
negative regulation of T cell mediated immune response to tumor cell	IDA	38377992
negative regulation of B cell apoptotic process	IEA

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process

leukocyte apoptotic process [inference]

lymphocyte apoptotic process [inference]

B cell apoptotic process

T cell apoptotic process [inference]

regulatory T cell apoptotic process

response to stimulus [inference]

immune response [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of tolerance induction [inference]

negative regulation of tolerance induction

negative regulation of immune system process [inference]

negative regulation of tolerance induction

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

negative regulation of immune effector process [inference]

negative regulation of leukocyte mediated immunity [inference]

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

negative regulation of T cell activation

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

regulation of immune effector process [inference]

negative regulation of immune effector process [inference]

negative regulation of leukocyte mediated immunity [inference]

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of leukocyte mediated immunity [inference]

negative regulation of leukocyte mediated immunity [inference]

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of lymphocyte mediated immunity [inference]

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of immune response

regulation of adaptive immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of immune response to tumor cell [inference]

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of leukocyte apoptotic process [inference]

positive regulation of lymphocyte apoptotic process [inference]

positive regulation of T cell apoptotic process

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of tolerance induction

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

negative regulation of immune effector process [inference]

negative regulation of leukocyte mediated immunity [inference]

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of leukocyte apoptotic process [inference]

negative regulation of lymphocyte apoptotic process [inference]

negative regulation of B cell apoptotic process

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of response to tumor cell [inference]

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of developmental process [inference]

negative regulation of tolerance induction

negative regulation of multicellular organismal process [inference]

negative regulation of tolerance induction

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of response to tumor cell [inference]

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of response to tumor cell [inference]

negative regulation of response to tumor cell [inference]

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of immune response to tumor cell [inference]

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of response to tumor cell [inference]

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of immune response

regulation of adaptive immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of immune response to tumor cell [inference]

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of T cell mediated immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated immune response to tumor cell

negative regulation of immune response to tumor cell [inference]

negative regulation of T cell mediated immune response to tumor cell

regulation of developmental process [inference]

negative regulation of developmental process [inference]

negative regulation of tolerance induction

regulation of cellular process [inference]

regulation of cell adhesion [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation

regulation of cell-cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation

regulation of leukocyte cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of leukocyte apoptotic process [inference]

positive regulation of lymphocyte apoptotic process [inference]

positive regulation of T cell apoptotic process

negative regulation of apoptotic process [inference]

negative regulation of leukocyte apoptotic process [inference]

negative regulation of lymphocyte apoptotic process [inference]

negative regulation of B cell apoptotic process

regulation of leukocyte apoptotic process [inference]

regulation of lymphocyte apoptotic process [inference]

regulation of B cell apoptotic process [inference]

negative regulation of B cell apoptotic process

negative regulation of lymphocyte apoptotic process [inference]

negative regulation of B cell apoptotic process

positive regulation of lymphocyte apoptotic process [inference]

positive regulation of T cell apoptotic process

regulation of T cell apoptotic process [inference]

positive regulation of T cell apoptotic process

negative regulation of leukocyte apoptotic process [inference]

negative regulation of lymphocyte apoptotic process [inference]

negative regulation of B cell apoptotic process

positive regulation of leukocyte apoptotic process [inference]

positive regulation of lymphocyte apoptotic process [inference]

positive regulation of T cell apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of leukocyte apoptotic process [inference]

positive regulation of lymphocyte apoptotic process [inference]

positive regulation of T cell apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of leukocyte apoptotic process [inference]

negative regulation of lymphocyte apoptotic process [inference]

negative regulation of B cell apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of leukocyte apoptotic process [inference]

positive regulation of lymphocyte apoptotic process [inference]

positive regulation of T cell apoptotic process

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of leukocyte apoptotic process [inference]

negative regulation of lymphocyte apoptotic process [inference]

negative regulation of B cell apoptotic process

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

negative regulation of T cell activation

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

negative regulation of T cell activation

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

negative regulation of multicellular organismal process [inference]

negative regulation of tolerance induction

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of T cell activation

Displaying **all 3** entries
GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IDA	30487606
external side of plasma membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

side of membrane [inference]

external side of plasma membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	15240681 17489864 20587542 21982860 23417675 26602187 28046066 30487606
signaling receptor activity	IDA	21276005 38377992

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Programmed cell death protein 1

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
V: Defense mechanisms

Displaying **all 3** entries
Gene Ontology
negative regulation of immune response
positive regulation of T cell apoptotic process
regulation of immune response

Displaying **all 6** entries
InterPro
Immunoglobulin V-set domain
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold
Programmed cell death protein 1

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:0080162	lupus nephritis	Alliance of Genome Resources
DOID:1883	hepatitis C	Alliance of Genome Resources
DOID:2043	hepatitis B	Alliance of Genome Resources
DOID:2048	autoimmune hepatitis	Alliance of Genome Resources
DOID:2377	multiple sclerosis	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources
DOID:9074	systemic lupus erythematosus	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 45 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus laevis	5133	Xenbase:XB-GENE-22167973
Mus musculus	18566	RGD:1311658	MOUSE29989
Rattus norvegicus	301626		RATNO42979
Canis lupus familiaris	486213		CANLF10191
Bos taurus	613842		BOVIN27536
Pan troglodytes	748796		PANTR30273
Equus caballus	100067948		HORSE37008
Felis catus	100135770		FELCA19992
Macaca mulatta	100135775		MACMU05848
Oryctolagus cuniculus	100343779		RABIT18030

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements