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pyruvate dehydrogenase kinase 1

Summary

Gene Symbol

PDK1

Organism

Homo sapiens (human)

External Links

NCBI Gene

5163

PubChem

5163

Alliance of Genome Resources

HGNC:8809

JoGo

PDK1

TogoVar

PDK1

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Kinase
Mitochondrion
Phosphoprotein
Proteomics identification
Pyruvate
Reference proteome
Transit peptide

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B7Z7N6
B7Z207
Q15118	Pyruvate dehydrogenase kinase isoform 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
glucose metabolic process	TAS	7499431
cell population proliferation	IMP	18541534
intrinsic apoptotic signaling pathway in response to oxidative stress	IMP	18541534
regulation of acetyl-CoA biosynthetic process from pyruvate	IBA
regulation of glucose metabolic process	IMP	18541534

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to oxidative stress

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to oxidative stress

hypoxia-inducible factor-1alpha signaling pathway

cell population proliferation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of cellular biosynthetic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of sulfur metabolic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of amide metabolic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of small molecule metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of cellular ketone metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of glucose metabolic process

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

regulation of glucose metabolic process

regulation of lipid metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to oxidative stress

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to oxidative stress

hypoxia-inducible factor-1alpha signaling pathway

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of cellular biosynthetic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of sulfur metabolic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

Displaying **all 4** entries
GO Term	Evidence Code	PMID
mitochondrion	IBA
mitochondrion	HTP	34800366
mitochondrial matrix	TAS
pyruvate dehydrogenase complex	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

oxidoreductase complex [inference]

pyruvate dehydrogenase complex

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein kinase activity	IDA	17683942
pyruvate dehydrogenase (acetyl-transferring) kinase activity	IDA	7499431
pyruvate dehydrogenase (acetyl-transferring) kinase activity	IMP	22195962
pyruvate dehydrogenase (acetyl-transferring) kinase activity	IBA
protein binding	IPI	17110931 26942675 27505672 29568061 32814053 7782287

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity

pyruvate dehydrogenase (acetyl-transferring) kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

pyruvate dehydrogenase (acetyl-transferring) kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity

pyruvate dehydrogenase (acetyl-transferring) kinase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Pyruvate dehydrogenase kinase

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
ATP binding
kinase activity
nucleotide binding
phosphorylation
pyruvate dehydrogenase (acetyl-transferring) kinase activity
regulation of glucose metabolic process
transferase activity

Displaying **all 6** entries
InterPro
Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily
Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal
Histidine kinase domain
Histidine kinase/HSP90-like ATPase superfamily
Histidine kinase/HSP90-like ATPase
PDK/BCKDK protein kinase