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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
acyl-CoA synthetase long chain family member 5
Summary
- Gene Symbol
-
- ACSL5
- Aliases
-
- ACS2
- ACS5
- FACL5 for fatty acid coenzyme A ligase 5
- fatty-acid-Coenzyme A ligase, long-chain 5
- long-chain acyl-CoA synthetase 5
- long-chain fatty acid coenzyme A ligase 5
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- ATP-binding
- Acetylation
- Alternative splicing
- Cell membrane
- Disease variant
- Endoplasmic reticulum
- Fatty acid metabolism
- Ligase
- Magnesium
- Mitochondrion outer membrane
- Phosphoprotein
- Reference proteome
- Signal-anchor
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| Q9ULC5 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| positive regulation of long-chain fatty acid import across plasma membrane | ||
| long-chain fatty acid metabolic process | ||
| long-chain fatty-acyl-CoA biosynthetic process |
GO Hierarchy
biological process
metabolic process [inference]
nitrogen compound metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
cellular nitrogen compound biosynthetic process [inference]
organonitrogen compound metabolic process [inference]
biosynthetic process [inference]
cellular metabolic process [inference]
cellular aromatic compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
aromatic compound biosynthetic process [inference]
phosphorus metabolic process [inference]
phosphate-containing compound metabolic process [inference]
organophosphate metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
cellular nitrogen compound biosynthetic process [inference]
cellular biosynthetic process [inference]
heterocycle metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
heterocycle biosynthetic process [inference]
primary metabolic process [inference]
small molecule metabolic process [inference]
organic substance metabolic process [inference]
organophosphate metabolic process [inference]
carbohydrate derivative metabolic process [inference]
organic cyclic compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
purine-containing compound metabolic process [inference]
organonitrogen compound metabolic process [inference]
organic substance biosynthetic process [inference]
cellular process [inference]
cellular metabolic process [inference]
cellular aromatic compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
aromatic compound biosynthetic process [inference]
phosphorus metabolic process [inference]
phosphate-containing compound metabolic process [inference]
organophosphate metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
cellular nitrogen compound biosynthetic process [inference]
cellular biosynthetic process [inference]
heterocycle metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
heterocycle biosynthetic process [inference]
biological regulation [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| endoplasmic reticulum | ||
| endoplasmic reticulum membrane |
|
|
| plasma membrane | ||
| mitochondrial outer membrane | ||
| membrane |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| oleoyl-CoA ligase activity | ||
| long-chain fatty acid-CoA ligase activity | ||
| arachidonate-CoA ligase activity | ||
| ATP binding | ||
| protein binding |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
KEGG BRITE Database
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050908 | myelodysplastic syndrome | |
| DOID:0060774 | congenital diarrhea | |
| DOID:0080199 | colorectal carcinoma | |
| DOID:10608 | celiac disease | |
| DOID:1168 | familial hyperlipidemia | |
| DOID:11847 | coronary thrombosis | |
| DOID:1584 | acute chest syndrome | |
| DOID:1612 | breast cancer | |
| DOID:162 | cancer | |
| DOID:2095 | sweat gland cancer |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0001397 | Hepatic steatosis |
| HP:0001508 | Failure to thrive |
| HP:0001988 | Recurrent hypoglycemia |
| HP:0002013 | Vomiting |
| HP:0002910 | Elevated circulating hepatic transaminase concentration |
| HP:0003073 | Hypoalbuminemia |
| HP:0003623 | Neonatal onset |
| HP:0005208 | Secretory diarrhea |
| Disease ID | Disease Name |
|---|---|
| OMIM:620357 |
|
PubChem Disease
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
LIPID MAPS Gene / Proteome Database
- LMPD ID
- LMP001504
- Gene Name
- acyl-CoA synthetase long-chain family member 5
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 171643 | WB:WBGene00022037 | ||
| 176785 | WB:WBGene00013575 | ||
| 40056 | FB:FBgn0036821 | ||
| 100185939 | CIOIN14164 | ||
| 103186542 | CALMI34901 | ||
| 102345307 | LATCH13425 | ||
| 447860 | ZFIN:ZDB-GENE-040912-169 | DANRE04452 | |
| 103039859 | ASTMX01509 | ||
| 108274215 | ICTPU04969 | ||
| 113587539 | ELEEL39606 |
