phospholipase C gamma 2

Summary
Gene Symbol
  • PLCG2
Organism
Homo sapiens (human)
External Links
NCBI Gene
5336
HGNC
9066
KEGG Gene ID
hsa:5336
PubChem
5336
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • Calcium
  • Disease variant
  • Hydrolase
  • Lipid degradation
  • Membrane
  • Phosphoprotein
  • Reference proteome
  • Repeat
  • SH2 domain
  • SH3 domain
  • Transducer
Proteins
Displaying 1 entry
UniProt Protein Name
P16885
  • Phosphoinositide phospholipase C-gamma-2
  • Phospholipase C-IV
  • Phospholipase C-gamma-2
Gene Ontology (GO)
GO Hierarchy
Human Protein Atlas
ENSG00000197943

soft tissue soft tissue blood blood blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node kidney kidney adrenal gland adrenal gland breast breast duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland nasopharynx nasopharynx tongue tonsil tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder ductus deferens ductus deferens seminal vesicle seminal vesicle seminal vesicle seminal vesicle testis testis epididymis epididymis brain smooth muscle urinary bladder prostate bone marrow skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus cartilage sole of foot sole of foot soft tissue blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lactating breast lactating breast kidney kidney adrenal gland adrenal gland duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland salivary gland salivary gland salivary gland salivary gland salivary gland nasopharynx tongue tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder brain skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus smooth muscle urinary bladder vagina ovary ovary fallopian tube fallopian tube endometrium placenta cervix cervix bone marrow cartilage sole of foot sole of foot olfactory region cerebral cortex cerebellum medulla pons midbrain pituitary gland hypothalamus amygdala thalamus choroid plexus choroid plexus corpus callosum basal ganglia substantia nigra dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe caudate hippocampus retina retina

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

KEGG BRITE Database
Orthology
K05859
Name
phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
References
Disease
Disease Ontology
Displaying entries 81 - 90 of 105 in total
DO ID Disease Name Source
DOID:3347 osteosarcoma
DOID:3361 childhood osteosarcoma
DOID:3376 bone osteosarcoma
DOID:3393 coronary artery disease
DOID:3459 breast carcinoma
DOID:3488 cellulitis
DOID:3571 liver cancer
DOID:3777 granuloma annulare
DOID:417 autoimmune disease
DOID:4448 macular degeneration
The Human Phenotype Ontology
Displaying entries 1 - 10 of 27 in total
HPO ID HPO Term
HP:0000006 Autosomal dominant inheritance
HP:0000403 Recurrent otitis media
HP:0000518 Cataract
HP:0000872 Hashimoto thyroiditis
HP:0000989 Pruritus
HP:0001045 Vitiligo
HP:0002099 Asthma
HP:0002720 Decreased circulating IgA level
HP:0002829 Arthralgia
HP:0002850 Decreased circulating total IgM
Displaying all 2 entries
Disease ID Disease Name
OMIM:614878
  • autoinflammation-PLCG2-associated antibody deficiency-immune dysregulation
OMIM:614468
  • familial cold autoinflammatory syndrome 3
LIPID MAPS Gene / Proteome Database
LMPD ID
LMP000965
Gene Name
phospholipase C, gamma 2 (phosphatidylinositol-specific)
Ortholog
Displaying entries 81 - 83 of 83 in total
Species Gene ID Alliance of Genome Resources Orthologous MAtrix
116449881 CORMO02267
103267377 CARSF01195
115619893 STRHB07368

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Last updated: August 19, 2024