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procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

Summary

Gene Symbol

PLOD1

Aliases

LH1
lysyl hydroxlase 1
procollagen lysyl hydroxylase 1

Organism

Homo sapiens (human)

External Links

NCBI Gene

5351

HGNC

9081

PubChem

5351

Alliance of Genome Resources

HGNC:9081

Annotation

Keyword

Alternative splicing
Dioxygenase
Direct protein sequencing
Disease variant
Ehlers-Danlos syndrome
Endoplasmic reticulum
Glycoprotein
Iron
Membrane
Metal-binding
Reference proteome
Signal
Vitamin C

Proteins

Displaying 1 entry
UniProt	Protein Name
Q02809	Lysyl hydroxylase 1

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
response to hypoxia	IEP	15174142
protein O-linked glycosylation	IDA	10934207
epidermis development	IMP	8449506
peptidyl-lysine hydroxylation	ISS	9582318
peptidyl-lysine hydroxylation	IDA	10934207 8621606 9724729

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

supramolecular fiber organization [inference]

collagen fibril organization

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

epidermis development

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

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GO Term	Evidence Code	PMID
extracellular space	IBA
endoplasmic reticulum	IBA
endoplasmic reticulum membrane	TAS
Golgi apparatus	IBA
rough endoplasmic reticulum membrane	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex

cellular anatomical entity [inference]

extracellular space

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

rough endoplasmic reticulum membrane

bounding membrane of organelle [inference]

rough endoplasmic reticulum membrane

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

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GO Term	Evidence Code	PMID
iron ion binding	IEA
protein binding	IPI	26496610 28514442 33961781
procollagen-lysine 5-dioxygenase activity	ISS	9582318
procollagen-lysine 5-dioxygenase activity	IDA	10934207 9724729
procollagen-lysine 5-dioxygenase activity	IMP	8621606

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

peptidyl-lysine 5-dioxygenase activity [inference]

procollagen-lysine 5-dioxygenase activity

dioxygenase activity [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

peptidyl-lysine 5-dioxygenase activity [inference]

procollagen-lysine 5-dioxygenase activity

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

glucosyltransferase activity [inference]

procollagen glucosyltransferase activity

catalytic activity, acting on a protein [inference]

procollagen glucosyltransferase activity

peptidyl-lysine 5-dioxygenase activity [inference]

procollagen-lysine 5-dioxygenase activity

binding [inference]

protein binding

carbohydrate binding [inference]

monosaccharide binding [inference]

L-ascorbic acid binding

small molecule binding [inference]

vitamin binding [inference]

L-ascorbic acid binding

organic acid binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

monosaccharide binding [inference]

L-ascorbic acid binding

heterocyclic compound binding [inference]

L-ascorbic acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

L-ascorbic acid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Procollagen-lysine,2-oxoglutarate 5-dioxygenase

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 7** entries
Gene Ontology
L-ascorbic acid binding
dioxygenase activity
iron ion binding
metal ion binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity
procollagen-proline 4-dioxygenase activity

Displaying **all 4** entries
InterPro
Oxoglutarate/iron-dependent dioxygenase
Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain
Prolyl 4-hydroxylase, alpha subunit
Prolyl 4-hydroxylase

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0080734	Ehlers-Danlos syndrome kyphoscoliotic type 1	Glyco-Disease Genes Database Alliance of Genome Resources
DOID:14775	brittle cornea syndrome 1	Glyco-Disease Genes Database

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	5351	Xenbase:XB-GENE-955414
Drosophila melanogaster	5352	FB:FBgn0036147
Drosophila melanogaster	8985	FB:FBgn0036147
Mus musculus	18822	Xenbase:XB-GENE-955414	MOUSE39572
Drosophila melanogaster	26432	FB:FBgn0036147
Drosophila melanogaster	26433	FB:FBgn0036147
Xenopus tropicalis	39265	Xenbase:XB-GENE-955414
Rattus norvegicus	116552		RATNO32979
Bos taurus	281409		BOVIN08265
Drosophila melanogaster	288583	FB:FBgn0036147

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External Links

Annotation

OrthoDB (Group)

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Acknowledgements