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plexin B3

Summary

Gene Symbol

PLXNB3

Organism

Homo sapiens (human)

External Links

NCBI Gene

5365

PubChem

5365

Alliance of Genome Resources

HGNC:9105

Annotation

Keyword

Alternative splicing
Cell membrane
Disulfide bond
Glycoprotein
Neurogenesis
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9ULL4
A8K920

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
negative regulation of GTPase activity	IMP	20696765
synapse assembly	IBA
positive regulation of neuron projection development	IDA	16122393
regulation of cell shape	IBA
negative regulation of cell adhesion	IBA IDA	15218527

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion [inference]

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

homophilic cell adhesion via plasma membrane adhesion molecules

signal transduction [inference]

cell surface receptor signaling pathway [inference]

semaphorin-plexin signaling pathway

cell motility [inference]

cell migration [inference]

cell chemotaxis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

synapse assembly

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly

synapse organization [inference]

synapse assembly

developmental process [inference]

anatomical structure development [inference]

system development [inference]

nervous system development

locomotion [inference]

taxis [inference]

chemotaxis [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

negative regulation of biological process [inference]

negative regulation of GTPase activity

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of cellular process [inference]

negative regulation of cell adhesion

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of lamellipodium assembly

negative regulation of lamellipodium organization [inference]

negative regulation of lamellipodium assembly

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

regulation of cell shape

regulation of axonogenesis [inference]

positive regulation of axonogenesis

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

semaphorin-plexin signaling pathway

regulation of cell adhesion [inference]

negative regulation of cell adhesion

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

regulation of epithelial cell proliferation [inference]

regulation of endothelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

regulation of cellular component biogenesis [inference]

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of lamellipodium assembly [inference]

negative regulation of lamellipodium assembly

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of lamellipodium assembly

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

negative regulation of cellular process [inference]

negative regulation of cell adhesion

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of lamellipodium assembly

negative regulation of lamellipodium organization [inference]

negative regulation of lamellipodium assembly

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of lamellipodium assembly

negative regulation of lamellipodium organization [inference]

negative regulation of lamellipodium assembly

positive regulation of cell projection organization [inference]

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of lamellipodium assembly [inference]

negative regulation of lamellipodium assembly

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of lamellipodium assembly

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

positive regulation of neuron projection development

regulation of axonogenesis [inference]

positive regulation of axonogenesis

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of lamellipodium assembly [inference]

negative regulation of lamellipodium assembly

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of lamellipodium assembly

regulation of lamellipodium organization [inference]

regulation of lamellipodium assembly [inference]

negative regulation of lamellipodium assembly

negative regulation of lamellipodium organization [inference]

negative regulation of lamellipodium assembly

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of lamellipodium assembly

negative regulation of lamellipodium organization [inference]

negative regulation of lamellipodium assembly

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

regulation of biological quality [inference]

regulation of cell shape

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of GTPase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of GTPase activity

regulation of hydrolase activity [inference]

regulation of GTPase activity [inference]

negative regulation of GTPase activity

negative regulation of hydrolase activity [inference]

negative regulation of GTPase activity

Displaying **all 3** entries
GO Term	Evidence Code	PMID
plasma membrane	IBA TAS
semaphorin receptor complex	IBA
cell surface	IDA	16122393

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

semaphorin receptor complex

cellular anatomical entity [inference]

cell surface

membrane [inference]

plasma membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	15184888 16122393 21706053
Rho GDP-dissociation inhibitor binding	IEA
semaphorin receptor activity	IBA IDA	15218527
protein domain specific binding	IPI	15218527
cell-cell adhesion mediator activity	IPI	16122393

GO Hierarchy

molecular function

binding [inference]

protein binding

protein domain specific binding

cell adhesion molecule binding [inference]

cell adhesion mediator activity [inference]

cell-cell adhesion mediator activity

GDP-dissociation inhibitor binding [inference]

Rho GDP-dissociation inhibitor binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

semaphorin receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Plexin A

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
negative regulation of cell adhesion
positive regulation of axonogenesis
regulation of cell migration
semaphorin receptor activity
semaphorin-plexin signaling pathway involved in axon guidance
semaphorin-plexin signaling pathway

Displaying entries **1 - 10** of 12 in total

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InterPro
IPT domain
Immunoglobulin E-set
Immunoglobulin-like fold
PSI domain
Plexin family
Plexin repeat
Plexin, cytoplasmic RasGAP domain
Plexin, cytoplasmic RhoGTPase-binding domain
Rho GTPase activation protein
Sema domain superfamily

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060037	developmental disorder of mental health	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 56 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	43766		FB:FBgn0025740
Mus musculus	140571		MGI:2154240	MOUSE64935
Rattus norvegicus	363517		RGD:1560615	RATNO44492
Pan troglodytes	465929	9598_0:005715		PANTR47075
Canis lupus familiaris	492243			CANLF20285
Danio rerio	566546		ZFIN:ZDB-GENE-081104-53	DANRE42325
Monodelphis domestica	100027947			MONDO36037
Ornithorhynchus anatinus	100080201			ORNAN23202
Pongo abelii	100441548	9601_0:0054ac
Ailuropoda melanoleuca	100464533			AILME02914

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements