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inducible T cell co-stimulator

Summary

Gene Symbol

Icos

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

54167

PubChem

54167

Alliance of Genome Resources

MGI:1858745

Annotation

Keyword

Disulfide bond
Glycoprotein
Immunoglobulin domain
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q9WVS0	Activation-inducible lymphocyte immunomediatory molecule CD28 and CTLA-4-like protein CD28-related protein 1
Q5SUZ7
Q3V3X2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cell-cell adhesion	IBA ISO
T cell tolerance induction	IBA ISO
T cell costimulation	IBA IEA ISO

GO Hierarchy

biological process

immune system process [inference]

tolerance induction [inference]

T cell tolerance induction

lymphocyte costimulation [inference]

T cell costimulation

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of cellular process [inference]

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

T cell costimulation

regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

Displaying **all 2** entries
GO Term	Evidence Code	PMID
external side of plasma membrane	IDA	10760791 16227984 19008373 23583643
plasma membrane	IDA	10760791

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

side of membrane [inference]

external side of plasma membrane

Displaying 1 entry
GO Term	Evidence Code	PMID
protein binding	IPI	10657606 10760791 27135603

GO Hierarchy

molecular function

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

Inducible T-cell costimulator

Functional Category

K: Transcription
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
T cell costimulation
T cell tolerance induction

Displaying **all 3** entries
InterPro
Immunoglobulin V-set domain
Immunoglobulin-like fold
Inducible T-cell costimulator

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:0060025	immunoglobulin alpha deficiency	Alliance of Genome Resources
DOID:0060180	colitis	Alliance of Genome Resources
DOID:0081144	common variable immunodeficiency 1	Alliance of Genome Resources
DOID:10608	celiac disease	Alliance of Genome Resources
DOID:12177	common variable immunodeficiency	Alliance of Genome Resources
DOID:13141	uveitis	Alliance of Genome Resources
DOID:820	myocarditis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 92 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	29851		HGNC:5351	HUMAN66529
Rattus norvegicus	64545	10116_1:003248	RGD:620123	RATNO43464
Canis lupus familiaris	403456			CANLF14145
Bos taurus	507026			BOVIN24620
Macaca mulatta	705788			MACMU06893
Sus scrofa	733597			PIGXX09848
Pan troglodytes	747295			PANTR29585
Equus caballus	100067953			HORSE13806
Taeniopygia guttata	100232284			TAEGU28573
Oryctolagus cuniculus	100352250			RABIT11940

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024