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DNA polymerase delta 1, catalytic subunit

Summary

Gene Symbol

POLD1

Organism

Homo sapiens (human)

External Links

NCBI Gene

5424

PubChem

5424

Alliance of Genome Resources

HGNC:9175

Annotation

Keyword

3D-structure
4Fe-4S
DNA excision
DNA repair
DNA replication
DNA-binding
DNA-directed DNA polymerase
Disease variant
Exonuclease
Isopeptide bond
Methylation
Nucleus
Proteomics identification
Reference proteome
Ubl conjugation
Zinc-finger

Proteins

Displaying **all 5** entries
UniProt	Protein Name
P28340	3'-5' exodeoxyribonuclease DNA polymerase subunit delta p125
M0R2B7
Q59FA0
A0A087WYJ2
Q308M6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 15** of 17 in total

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GO Term	Evidence Code	PMID
nucleotide-excision repair, DNA gap filling	IBA
response to UV	TAS	3146346
cellular response to UV	IDA	24939902
DNA replication proofreading	IBA
fatty acid homeostasis	IMP	23770608

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

DNA replication proofreading

DNA-templated DNA replication maintenance of fidelity [inference]

DNA replication proofreading

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

DNA replication proofreading

DNA-templated DNA replication maintenance of fidelity [inference]

DNA replication proofreading

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

DNA replication proofreading

DNA-templated DNA replication maintenance of fidelity [inference]

DNA replication proofreading

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

DNA replication proofreading

DNA-templated DNA replication maintenance of fidelity [inference]

DNA replication proofreading

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

DNA replication proofreading

DNA-templated DNA replication maintenance of fidelity [inference]

DNA replication proofreading

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

DNA replication proofreading

DNA-templated DNA replication maintenance of fidelity [inference]

DNA replication proofreading

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

DNA replication proofreading

DNA-templated DNA replication maintenance of fidelity [inference]

DNA replication proofreading

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

DNA replication proofreading

DNA-templated DNA replication maintenance of fidelity [inference]

DNA replication proofreading

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

DNA replication proofreading

DNA-templated DNA replication maintenance of fidelity [inference]

DNA replication proofreading

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

DNA replication proofreading

DNA-templated DNA replication maintenance of fidelity [inference]

DNA replication proofreading

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair

translesion synthesis [inference]

error-free translesion synthesis

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

DNA replication proofreading

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

fatty acid homeostasis

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

DNA replication proofreading

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

response to UV

cellular response to UV

cellular response to light stimulus [inference]

cellular response to UV

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

DNA replication proofreading

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
nucleotide-excision repair complex	IDA	20713449
chromosome, telomeric region	IDA	24270157
nucleus	IDA	16762037
nucleoplasm	TAS
nucleoplasm	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

intracellular protein-containing complex [inference]

DNA polymerase complex [inference]

delta DNA polymerase complex

catalytic complex [inference]

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

DNA polymerase complex [inference]

delta DNA polymerase complex

cellular anatomical entity [inference]

intracellular anatomical structure [inference]

inclusion body [inference]

aggresome

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

chromosomal region [inference]

chromosome, telomeric region

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
nucleotide binding	IEA
DNA binding	IDA	16762037
chromatin binding	IDA	16762037 24939902
damaged DNA binding	IDA	24939902
DNA-directed DNA polymerase activity	IMP	16762037

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity [inference]

DNA polymerase activity [inference]

DNA-directed DNA polymerase activity

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

nuclease activity [inference]

exonuclease activity [inference]

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

3'-5'-DNA exonuclease activity

3'-5' exonuclease activity [inference]

3'-5'-DNA exonuclease activity

exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

3'-5'-DNA exonuclease activity

DNA nuclease activity [inference]

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

3'-5'-DNA exonuclease activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA nuclease activity [inference]

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

3'-5'-DNA exonuclease activity

DNA polymerase activity [inference]

DNA-directed DNA polymerase activity

binding [inference]

protein binding

enzyme binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

protein-containing complex binding [inference]

chromatin binding

metal cluster binding [inference]

iron-sulfur cluster binding [inference]

4 iron, 4 sulfur cluster binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

damaged DNA binding

nucleoside phosphate binding [inference]

nucleotide binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

polymerase

Functional Category

K: Transcription
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
4 iron, 4 sulfur cluster binding
iron-sulfur cluster binding
metal ion binding
nucleotide binding
nucleotidyltransferase activity
transferase activity

Displaying **all 10** entries
InterPro
C4-type zinc-finger of DNA polymerase delta
DNA polymerase family B, thumb domain
DNA polymerase, palm domain superfamily
DNA-directed DNA polymerase, family B, conserved site
DNA-directed DNA polymerase, family B, exonuclease domain
DNA-directed DNA polymerase, family B, multifunctional domain
DNA-directed DNA polymerase, family B
DNA/RNA polymerase superfamily
Ribonuclease H superfamily
Ribonuclease H-like superfamily

Ortholog

Displaying entries **1 - 10** of 59 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	5424	Xenbase:XB-GENE-1002131
Mus musculus	18971		MOUSE52371
Rattus norvegicus	59294		RATNO16010
Bos taurus	281990		BOVIN11592
Pan troglodytes	456228		PANTR19024
Pan troglodytes	469098		PANTR19024
Danio rerio	556456		DANRE30876
Ciona intestinalis	100178968		CIOIN04279
Salmo salar	100380397		SALSA130567
Callithrix jacchus	100389890		CALJA24160

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Acknowledgements