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DNA polymerase epsilon 2, accessory subunit

Summary

Gene Symbol

POLE2

Organism

Homo sapiens (human)

External Links

NCBI Gene

5427

PubChem

5427

Alliance of Genome Resources

HGNC:9178

Annotation

Keyword

3D-structure
Alternative splicing
DNA replication
DNA-binding
Nucleus
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P56282	DNA polymerase II subunit 2 DNA polymerase epsilon subunit B

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
DNA replication	TAS	9405441
DNA-templated DNA replication	IDA	33051204
DNA-templated DNA replication	IBA
DNA repair	TAS	9405441
error-prone translesion synthesis	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-prone translesion synthesis

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
nucleoplasm	TAS
nucleoplasm	IDA
epsilon DNA polymerase complex	IDA	10801849 22465957
epsilon DNA polymerase complex	IBA
epsilon DNA polymerase complex	IPI	10801849

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

epsilon DNA polymerase complex

intracellular protein-containing complex [inference]

DNA polymerase complex [inference]

epsilon DNA polymerase complex

catalytic complex [inference]

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

DNA polymerase complex [inference]

epsilon DNA polymerase complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying **all 3** entries
GO Term	Evidence Code	PMID
DNA binding	IEA
DNA-directed DNA polymerase activity	TAS	9405441
protein binding	IPI	10801849 25416956 28514442 31515488 32296183 33961781

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity [inference]

DNA polymerase activity [inference]

DNA-directed DNA polymerase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA polymerase activity [inference]

DNA-directed DNA polymerase activity

binding [inference]

protein binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

DNA polymerase

Functional Category

E: Amino acid transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
error-prone translesion synthesis

Displaying **all 2** entries
InterPro
DNA polymerase alpha/delta/epsilon, subunit B
DNA polymerase epsilon, subunit B

Ortholog

Displaying entries **1 - 10** of 63 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	5427	Xenbase:XB-GENE-973812
Mus musculus	18974		MOUSE08322
Rattus norvegicus	299112		RATNO35887
Pan troglodytes	452888		PANTR08690
Bos taurus	518653		BOVIN01119
Canis lupus familiaris	608973		CANLF17890
Macaca mulatta	707526		MACMU42615
Equus caballus	100065785		HORSE16664
Ornithorhynchus anatinus	100084529		ORNAN06523
Taeniopygia guttata	100218053		TAEGU25470

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

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OrthoDB (Group)

International Collaboration

Acknowledgements