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paraoxonase 1

Summary

Gene Symbol

PON1

Aliases

ESA
arylesterase 1
esterase A

Organism

Homo sapiens (human)

External Links

NCBI Gene

5444

HGNC

9204

PubChem

5444

Alliance of Genome Resources

HGNC:9204

JoGo

PON1

TogoVar

PON1

Annotation

Keyword

3D-structure
Calcium
Direct protein sequencing
Disulfide bond
Glycoprotein
HDL
Hydrolase
Metal-binding
Proteomics identification
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P27169	Aromatic esterase 1 K-45 Serum aryldialkylphosphatase 1

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
cholesterol metabolic process	IEA
response to toxic substance	IDA	15772423
response to toxic substance	IBA
positive regulation of cholesterol efflux	IDA	15721011
negative regulation of plasma lipoprotein oxidation	IDA	15342686

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

phosphatidylcholine metabolic process

catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

heterocycle catabolic process [inference]

lactone catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

organophosphate catabolic process

organic cyclic compound catabolic process [inference]

lactone catabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

carboxylic acid catabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

organophosphate catabolic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

heterocycle catabolic process [inference]

lactone catabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

heterocycle metabolic process [inference]

heterocycle catabolic process [inference]

lactone catabolic process

lactone metabolic process [inference]

lactone catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

carboxylic acid catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

carboxylic acid catabolic process

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

organophosphate catabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

lactone metabolic process [inference]

lactone catabolic process

organic cyclic compound catabolic process [inference]

lactone catabolic process

organonitrogen compound metabolic process [inference]

phosphatidylcholine metabolic process

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

organophosphate catabolic process

organic cyclic compound catabolic process [inference]

lactone catabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

carboxylic acid catabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

organophosphate catabolic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

heterocycle catabolic process [inference]

lactone catabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

heterocycle metabolic process [inference]

heterocycle catabolic process [inference]

lactone catabolic process

lactone metabolic process [inference]

lactone catabolic process

response to stimulus [inference]

response to chemical [inference]

response to toxic substance

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of cholesterol transport [inference]

regulation of cholesterol efflux [inference]

positive regulation of cholesterol efflux

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of lipid localization [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of cholesterol transport [inference]

regulation of cholesterol efflux [inference]

positive regulation of cholesterol efflux

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

positive regulation of biological process [inference]

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of plasma lipoprotein oxidation

negative regulation of multicellular organismal process [inference]

negative regulation of plasma lipoprotein oxidation

regulation of cellular process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of plasma lipoprotein oxidation

regulation of cellular component organization [inference]

regulation of plasma lipoprotein oxidation [inference]

negative regulation of plasma lipoprotein oxidation

negative regulation of cellular component organization [inference]

negative regulation of plasma lipoprotein oxidation

regulation of multicellular organismal process [inference]

regulation of plasma lipoprotein oxidation [inference]

negative regulation of plasma lipoprotein oxidation

negative regulation of multicellular organismal process [inference]

negative regulation of plasma lipoprotein oxidation

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GO Term	Evidence Code	PMID
extracellular region	NAS	14718574
extracellular region	TAS
extracellular space	IDA	7638166
extracellular space	IBA
endoplasmic reticulum membrane	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-lipid complex [inference]

lipoprotein particle [inference]

plasma lipoprotein particle [inference]

high-density lipoprotein particle

spherical high-density lipoprotein particle

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

blood microparticle

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GO Term	Evidence Code	PMID
aryldialkylphosphatase activity	IDA	15098021 7638166
aryldialkylphosphatase activity	IBA
arylesterase activity	NAS	1673382
arylesterase activity	IDA	15098021 7638166
arylesterase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

aryldialkylphosphatase activity

carboxylic ester hydrolase activity [inference]

arylesterase activity

lactonohydrolase activity [inference]

acyl-L-homoserine-lactone lactonohydrolase activity

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

lipid binding [inference]

phospholipid binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

serum paraoxonase/arylesterase

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
arylesterase activity
hydrolase activity
metal ion binding
response to toxic substance

Displaying **all 2** entries
InterPro
Arylesterase
Six-bladed beta-propeller, TolB-like

Rhea

RHEA:22576

H₂O + an N-acyl-L-homoserine lactone

H⁺ + an N-acyl-L-homoserine

Enzyme

3.1.1.81

PMID

RHEA:18053

H₂O + paraoxon

diethylphosphate + H⁺ + 4-nitrophenol

Enzyme

3.1.8.1

PMID

RHEA:17309

a phenyl acetate + H₂O

H⁺ + acetate + a phenol

Enzyme

3.1.1.2

PMID

Disease

Disease Ontology

Displaying entries **11 - 20** of 29 in total

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DO ID	Disease Name	Source
DOID:11713	diabetic angiopathy	Alliance of Genome Resources
DOID:11758	iron deficiency anemia	Alliance of Genome Resources
DOID:1307	dementia	Alliance of Genome Resources
DOID:14400	capillary leak syndrome	Alliance of Genome Resources
DOID:1612	breast cancer	Alliance of Genome Resources
DOID:1727	retinal vein occlusion	Alliance of Genome Resources
DOID:1936	atherosclerosis	Alliance of Genome Resources
DOID:2349	arteriosclerosis	Alliance of Genome Resources
DOID:2355	anemia	Alliance of Genome Resources
DOID:3393	coronary artery disease	Alliance of Genome Resources

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0000217	Xerostomia
HP:0000708	Atypical behavior
HP:0000712	Emotional lability
HP:0000713	Agitation
HP:0000716	Depression
HP:0000739	Anxiety
HP:0001257	Spasticity
HP:0001260	Dysarthria
HP:0001347	Hyperreflexia
HP:0002015	Dysphagia

Displaying 1 entry
Disease ID	Disease Name
ORPHA:803	amyotrophic lateral sclerosis frontotemporal dementia and/or amyotrophic lateral sclerosis 3

PubChem Disease

MedGen Diseases

Microvascular complications of diabetes, susceptibility to, 5

OMIM Phenotypes

MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 5; MVCD5

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002196
Gene Name: paraoxonase 1

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements