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UDP-glucose glycoprotein glucosyltransferase 2

Summary

Gene Symbol

UGGT2

Aliases

FLJ10873
FLJ11485
HUGT2
MGC117360
MGC150689
MGC87276
UDP-glucose:glycoprotein glucosyltransferase 2

Organism

Homo sapiens (human)

External Links

NCBI Gene

55757

GGDB ID

gg153

HGNC

15664

mRNA

NM_020121

map

13q32.1

Protein

NP_064506

OMIM

605898

KEGG Gene ID

hsa:55757

PubChem

55757

Alliance of Genome Resources

HGNC:15664

Annotation

Keyword

Alternative splicing
Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Phosphoprotein
Reference proteome
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9NYU1	UDP--Glc:glycoprotein glucosyltransferase 2 UDP-glucose ceramide glucosyltransferase-like 1
Q05D90

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein N-linked glycosylation via asparagine	IBA
ERAD pathway	IBA
UDP-glucosylation	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-glucose metabolic process [inference]

UDP-glucosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-glucose metabolic process [inference]

UDP-glucosylation

phosphorus metabolic process [inference]

UDP-glucose metabolic process [inference]

UDP-glucosylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-glucose metabolic process [inference]

UDP-glucosylation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-glucose metabolic process [inference]

UDP-glucosylation

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-glucose metabolic process [inference]

UDP-glucosylation

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-glucose metabolic process [inference]

UDP-glucosylation

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

carbohydrate derivative metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-glucose metabolic process [inference]

UDP-glucosylation

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-glucose metabolic process [inference]

UDP-glucosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-glucose metabolic process [inference]

UDP-glucosylation

phosphorus metabolic process [inference]

UDP-glucose metabolic process [inference]

UDP-glucosylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-glucose metabolic process [inference]

UDP-glucosylation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-glucose metabolic process [inference]

UDP-glucosylation

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

ERAD pathway

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

ERAD pathway

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

Displaying **all 4** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum lumen	ISS TAS
endoplasmic reticulum-Golgi intermediate compartment	IEA
endoplasmic reticulum	IBA
protein-containing complex	IDA	23349634

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
UDP-glucose:glycoprotein glucosyltransferase activity	IBA ISS TAS
protein binding	IPI	23349634 25416956 36217029
unfolded protein binding	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

UDP-glucosyltransferase activity [inference]

UDP-glucose:glycoprotein glucosyltransferase activity

hexosyltransferase activity [inference]

glucosyltransferase activity [inference]

UDP-glucosyltransferase activity [inference]

UDP-glucose:glycoprotein glucosyltransferase activity

binding [inference]

protein binding

unfolded protein binding

Gene Ontology information from NCBI Gene and UniProt.

GlycoGene Database (GGDB)

GGDB ID

gg153

Gene Symbol

UGGT2

Reactions

Displaying 1 entry
Donor	Acceptor	Product	Reference
UDP-Glc	G60230HH	G19958IL	24415556

Displaying 1 entry
Donor	Acceptor	Product	Reference
UDP-Glc	G60230HH	G19958IL	24415556

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Rattus norvegicus	XP_224524	XM_224524
Mus musculus	BAC34847	AK052077

KEGG BRITE Database

Orthology

K11718

Name

UDP-glucose:glycoprotein glucosyltransferase [EC:2.4.1.-]

References

10694380

Disease

Disease Ontology

Displaying **all 8** entries
DO ID	Disease Name	Source
DOID:11847	coronary thrombosis	DisGeNET
DOID:162	cancer	DisGeNET DisGeNET
DOID:4766	embryoma	DisGeNET
DOID:5844	myocardial infarction	DisGeNET
DOID:5854	silent myocardial infarction	DisGeNET
DOID:9351	diabetes mellitus	DisGeNET
DOID:9352	type 2 diabetes mellitus	DisGeNET
DOID:9408	acute myocardial infarction	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP006809
Gene Name: UDP-glucose glycoprotein glucosyltransferase 2

Ortholog

Displaying entries **81 - 90** of 91 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Amphiprion ocellaris	111569951		AMPOC08066
Chelonoidis abingdonii	116827453		CHEAB17519
Hippocampus comes	109523375		HIPCM06611
Cynoglossus semilaevis	103391830		CYNSE10848
Propithecus coquereli	105812792		PROCO20707
Saccharomyces cerevisiae S288C	854514	SGD:S000005863
Cyprinus carpio carpio	109045481		CYPCA49734
Cyprinus carpio carpio	109101704		CYPCA43743
Nannospalax galili	103726159		NANGA08696
Corvus moneduloides	116439943		CORMO14399

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.0.0

Last updated: August 19, 2024