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protein S
Summary
- Gene Symbol
-
- PROS1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Calcium
- Cleavage on pair of basic residues
- Disease variant
- Disulfide bond
- EGF-like domain
- Fibrinolysis
- Gamma-carboxyglutamic acid
- Glycoprotein
- Hydroxylation
- Proteomics identification
- Reference proteome
- Repeat
- Secreted
- Signal
- Thrombophilia
- Zymogen
- Proteins
| UniProt | Protein Name |
|---|---|
| A0A0S2Z4K3 |
|
| P07225 |
|
| A0A0S2Z4L3 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| blood coagulation | ||
| fibrinolysis | ||
| positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| Golgi membrane | ||
| extracellular region | ||
| extracellular region | ||
| extracellular space | ||
| extracellular space |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| endopeptidase inhibitor activity | ||
| calcium ion binding | ||
| protein binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Kinase
- Functional Category
-
- J: Translation, ribosomal structure and biogenesis
- K: Transcription
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| ATP binding |
| kinase activity |
| nucleotide binding |
| phosphorylation |
| InterPro |
|---|
| Protein kinase domain |
| Protein kinase-like domain superfamily |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0111900 | autosomal dominant thrombophilia due to protein S deficiency | |
| DOID:0111905 | autosomal recessive thrombophilia due to protein S deficiency | |
| DOID:2451 | protein S deficiency | |
| DOID:3526 | cerebral infarction |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 5627 | Xenbase:XB-GENE-980521 | ||
| 19128 | Xenbase:XB-GENE-980521 | MOUSE18419 | |
| 81750 | RATNO04818 | ||
| 282006 | BOVIN14341 | ||
| 397388 | PIGXX05905 | ||
| 460533 | PANTR31640 | ||
| 694845 | MACMU29229 | ||
| 768180 | DANRE16892 | ||
| 100009314 | RABIT04912 | ||
| 100030929 | MONDO31692 |
