Submissions
GlyTouCan
Glycan Structure Repository
GlyComb
Glycoconjugate Repository
GlycoPOST
Glycomics MS raw data Repository
UniCarb-DR
Glycomics MS Repository for glycan annotations from GlycoWorkbench
LM-GlycoRepo
Repository for lectin-assisted multimodality data
All Resources
Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / OrganismsTools
SugarDrawer
GlycanBuilder
Glycan Converters
GlycoMaple
GlycomeAtlas
LM-GlycomeAtlas
GALAXY
MCAW
GlycoSim
GRable
Guidelines
MIRAGE
Vitamin K-dependent protein S
Summary
- UniProt ID
- P07225
- Gene Symbol
-
- PROS
- PROS1
- Gene ID
- 5627
- Organism
- Homo sapiens (human)
External Links
- GlyConnect
- GlyGen
- P07225
- PubChem
- P07225
- The Human Metabolome Database
- HMDBP02003
- Re-Glyco
- P07225
Annotation
- Keyword
-
- 3D-structure
- Calcium
- Cleavage on pair of basic residues
- Disease variant
- Disulfide bond
- EGF-like domain
- Fibrinolysis
- Gamma-carboxyglutamic acid
- Glycoprotein
- Hydroxylation
- Reference proteome
- Repeat
- Secreted
- Signal
- Thrombophilia
- Zymogen
- Gene Ontology (GO)
| GO Term |
|---|
| blood coagulation |
| fibrinolysis |
| positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO Term |
|---|
| endopeptidase inhibitor activity |
| calcium ion binding |
- Site Annotations
| Position | Description |
|---|---|
| 499 | Not glycosylated; in variant Heerlen |
Sequence
MRVLGGRCGALLACLLLVLPVSEANFLSKQQASQVLVRKRRANSLLEETKQGNLERECIEELCNKEEAREVFENDPETDYFYPKYLVCLRSFQTGLFTAARQSTNAYPDLRSCVNAIPDQCSPLPCNEDGYMSCKDGKASFTCTCKPGWQGEKCEFDINECKDPSNINGGCSQICDNTPGSYHCSCKNGFVMLSNKKDCKDVDECSLKPSICGTAVCKNIPGDFECECPEGYRYNLKSKSCEDIDECSENMCAQLCVNYPGGYTCYCDGKKGFKLAQDQKSCEVVSVCLPLNLDTKYELLYLAEQFAGVVLYLKFRLPEISRFSAEFDFRTYDSEGVILYAESIDHSAWLLIALRGGKIEVQLKNEHTSKITTGGDVINNGLWNMVSVEELEHSISIKIAKEAVMDINKPGPLFKPENGLLETKVYFAGFPRKVESELIKPINPRLDGCIRSWNLMKQGASGIKEIIQEKQNKHCLVTVEKGSYYPGSGIAQFHIDYNNVSSAEGWHVNVTLNIRPSTGTGVMLALVSGNNTVPFAVSLVDSTSEKSQDILLSVENTVIYRIQALSLCSDQQSHLEFRVNRNNLELSTPLKIETISHEDLQRQLAVLDKAMKAKVATYLGGLPDVPFSATPVNAFYNGCMEVNINGVQLDLDEAISKHNDIRAHSCPSVWKKTKNS
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 91 |
|
|||
| 102 |
|
|||
| 104 |
|
|||
| 122 |
|
|||
| 499 |
|
|
||
| 509 | N-linked (GlcNAc...) asparagine |
|
||
| 530 | N-linked (GlcNAc...) asparagine |
G57321FI
G43417UB
G00912UN
G48414YA
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Cell surface interactions at the vascular wall | Homo sapiens |
| Common Pathway of Fibrin Clot Formation | Homo sapiens |
| Gamma-carboxylation of protein precursors | Homo sapiens |
| Intrinsic Pathway of Fibrin Clot Formation | Homo sapiens |
| Platelet degranulation | Homo sapiens |
| Regulation of Complement cascade | Homo sapiens |
| Removal of aminoterminal propeptides from gamma-carboxylated proteins | Homo sapiens |
| Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0111900 | autosomal dominant thrombophilia due to protein S deficiency | |
| DOID:0111905 | autosomal recessive thrombophilia due to protein S deficiency | |
| DOID:2451 | protein S deficiency | |
| DOID:3526 | cerebral infarction |
