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diacylglycerol O-acyltransferase 2

Summary

Gene Symbol

dgat2

Organism

Danio rerio (zebrafish)

External Links

NCBI Gene

565316

PubChem

565316

Alliance of Genome Resources

ZFIN:ZDB-GENE-050913-15

Annotation

Keyword

Acyltransferase
Cytoplasm
Endoplasmic reticulum
Glycerol metabolism
Lipid biosynthesis
Lipid droplet
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q4V9F0	Acyl-CoA retinol O-fatty-acyltransferase Diglyceride acyltransferase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
triglyceride biosynthetic process	IBA IEA ISS
diacylglycerol biosynthetic process	ISS
lipid metabolic process	IEA
response to (R)-carnitine	IEP	28102299
regulation of response to endoplasmic reticulum stress	IGI	28027591

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

cellular metabolic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride biosynthetic process

diacylglycerol metabolic process [inference]

diacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride biosynthetic process

diacylglycerol metabolic process [inference]

diacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

primary metabolic process [inference]

carbohydrate metabolic process [inference]

alditol metabolic process [inference]

glycerol metabolic process

lipid metabolic process

lipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride biosynthetic process

diacylglycerol metabolic process [inference]

diacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride biosynthetic process

diacylglycerol metabolic process [inference]

diacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

alditol metabolic process [inference]

glycerol metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

alditol metabolic process [inference]

glycerol metabolic process

lipid metabolic process

lipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride biosynthetic process

diacylglycerol metabolic process [inference]

diacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride biosynthetic process

diacylglycerol metabolic process [inference]

diacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

alditol metabolic process [inference]

glycerol metabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride biosynthetic process

diacylglycerol metabolic process [inference]

diacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride biosynthetic process

diacylglycerol metabolic process [inference]

diacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to (R)-carnitine

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to (R)-carnitine

biological regulation [inference]

regulation of biological process [inference]

regulation of response to stimulus [inference]

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress

regulation of cellular process [inference]

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum	IEA
cytoplasm	IEA
lipid droplet	IEA ISS
endoplasmic reticulum membrane	IBA ISS
membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane

organelle membrane [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

lipid droplet

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular non-membrane-bounded organelle [inference]

lipid droplet

Displaying **all 5** entries
GO Term	Evidence Code	PMID
transferase activity	IEA
diacylglycerol O-acyltransferase activity	IBA IEA ISS
O-acyltransferase activity	IEA
acyltransferase activity	IEA
retinol O-fatty-acyltransferase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity

acyltransferase activity

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

O-acyltransferase activity

acylglycerol O-acyltransferase activity [inference]

diacylglycerol O-acyltransferase activity

retinol O-fatty-acyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0080208	metabolic dysfunction-associated steatotic liver disease	Alliance of Genome Resources
DOID:10787	premature menopause	Alliance of Genome Resources
DOID:784	chronic kidney disease	Alliance of Genome Resources
DOID:9452	steatotic liver disease	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 50** of 83 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Bos taurus	404129		BOVIN07268
Bos taurus	614285		BOVIN07268
Capra hircus	102174409		CAPHI05536
Oryctolagus cuniculus	100354838		RABIT00799
Cricetulus griseus	100774981		CRIGR16245
Mus musculus	67800	MGI:1915050	MOUSE54916
Rattus norvegicus	252900	RGD:620329	RATNO18118
Cavia porcellus	100718670		CAVPO15464
Octodon degus	101589933		OCTDE10160
Heterocephalus glaber	101698712		HETGA04664