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SLAM family member 8

Summary

Gene Symbol

SLAMF8

Organism

Homo sapiens (human)

External Links

NCBI Gene

56833

PubChem

56833

Alliance of Genome Resources

HGNC:21391

Annotation

Keyword

Alternative splicing
Direct protein sequencing
Disulfide bond
Glycoprotein
Immunoglobulin domain
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9P0V8	B-lymphocyte activator macrophage expressed BCM-like membrane protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
leukocyte chemotaxis involved in inflammatory response	ISS
B-1 B cell lineage commitment	ISS	11313408
immune response	IBA
negative regulation of macrophage chemotaxis	ISS
regulation of NAD(P)H oxidase activity	ISS

GO Hierarchy

biological process

immune system process [inference]

immune response

leukocyte migration [inference]

leukocyte migration involved in inflammatory response [inference]

leukocyte chemotaxis involved in inflammatory response

leukocyte chemotaxis [inference]

leukocyte chemotaxis involved in inflammatory response

cellular process [inference]

cellular developmental process [inference]

cell fate commitment [inference]

B cell lineage commitment [inference]

B-1 B cell lineage commitment

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

leukocyte migration involved in inflammatory response [inference]

leukocyte chemotaxis involved in inflammatory response

leukocyte chemotaxis [inference]

leukocyte chemotaxis involved in inflammatory response

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

leukocyte chemotaxis involved in inflammatory response

developmental process [inference]

cellular developmental process [inference]

cell fate commitment [inference]

B cell lineage commitment [inference]

B-1 B cell lineage commitment

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

leukocyte chemotaxis involved in inflammatory response

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

phagosome acidification

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

phagosome acidification

monoatomic cation homeostasis [inference]

regulation of pH [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

phagosome acidification

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

phagosome acidification

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

phagosome acidification

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to bacterium

immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

biological regulation [inference]

regulation of pH [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

phagosome acidification

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of mononuclear cell migration [inference]

negative regulation of neutrophil migration

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

negative regulation of immune effector process [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of leukocyte migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of mononuclear cell migration [inference]

negative regulation of neutrophil migration

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

regulation of leukocyte chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

regulation of macrophage chemotaxis [inference]

negative regulation of macrophage chemotaxis

regulation of monocyte chemotaxis [inference]

negative regulation of monocyte chemotaxis

regulation of dendritic cell chemotaxis [inference]

negative regulation of dendritic cell chemotaxis

regulation of mononuclear cell migration [inference]

negative regulation of mononuclear cell migration [inference]

regulation of monocyte chemotaxis [inference]

negative regulation of monocyte chemotaxis

regulation of dendritic cell chemotaxis [inference]

negative regulation of dendritic cell chemotaxis

regulation of neutrophil migration [inference]

negative regulation of neutrophil migration

regulation of macrophage migration [inference]

regulation of macrophage chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

regulation of leukocyte activation [inference]

regulation of lymphocyte activation [inference]

regulation of lymphocyte differentiation [inference]

regulation of B cell differentiation

regulation of B cell activation [inference]

regulation of B cell differentiation

regulation of immune effector process [inference]

negative regulation of immune effector process [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of respiratory burst involved in inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of immune response [inference]

regulation of innate immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of respiratory burst involved in inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

regulation of B cell differentiation

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of respiratory burst [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of cellular metabolic process [inference]

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of kinase activity

regulation of respiratory burst [inference]

regulation of respiratory burst involved in inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of respiratory burst [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of mononuclear cell migration [inference]

negative regulation of neutrophil migration

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

regulation of chemotaxis [inference]

regulation of leukocyte chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

regulation of macrophage chemotaxis [inference]

negative regulation of macrophage chemotaxis

regulation of monocyte chemotaxis [inference]

negative regulation of monocyte chemotaxis

regulation of dendritic cell chemotaxis [inference]

negative regulation of dendritic cell chemotaxis

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of mononuclear cell migration [inference]

negative regulation of neutrophil migration

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

regulation of leukocyte chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

regulation of macrophage chemotaxis [inference]

negative regulation of macrophage chemotaxis

regulation of monocyte chemotaxis [inference]

negative regulation of monocyte chemotaxis

regulation of dendritic cell chemotaxis [inference]

negative regulation of dendritic cell chemotaxis

regulation of mononuclear cell migration [inference]

negative regulation of mononuclear cell migration [inference]

regulation of monocyte chemotaxis [inference]

negative regulation of monocyte chemotaxis

regulation of dendritic cell chemotaxis [inference]

negative regulation of dendritic cell chemotaxis

regulation of neutrophil migration [inference]

negative regulation of neutrophil migration

regulation of macrophage migration [inference]

regulation of macrophage chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of mononuclear cell migration [inference]

negative regulation of neutrophil migration

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of mononuclear cell migration [inference]

negative regulation of neutrophil migration

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of mononuclear cell migration [inference]

negative regulation of neutrophil migration

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

negative regulation of immune effector process [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of metabolic process [inference]

negative regulation of respiratory burst [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of locomotion [inference]

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of mononuclear cell migration [inference]

negative regulation of neutrophil migration

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

negative regulation of cellular process [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of mononuclear cell migration [inference]

negative regulation of neutrophil migration

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of multicellular organismal process [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of innate immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of respiratory burst involved in inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

regulation of innate immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of respiratory burst involved in inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of inflammatory response [inference]

negative regulation of inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of respiratory burst involved in inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of chemotaxis [inference]

regulation of leukocyte chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

regulation of macrophage chemotaxis [inference]

negative regulation of macrophage chemotaxis

regulation of monocyte chemotaxis [inference]

negative regulation of monocyte chemotaxis

regulation of dendritic cell chemotaxis [inference]

negative regulation of dendritic cell chemotaxis

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of immune response [inference]

regulation of innate immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of respiratory burst involved in inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of innate immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of respiratory burst involved in inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of inflammatory response [inference]

negative regulation of inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of respiratory burst involved in inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of cell development [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

regulation of B cell differentiation

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

regulation of B cell differentiation

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of kinase activity

regulation of cell differentiation [inference]

regulation of cell development [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

regulation of B cell differentiation

negative regulation of cellular process [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of mononuclear cell migration [inference]

negative regulation of neutrophil migration

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

regulation of lymphocyte activation [inference]

regulation of lymphocyte differentiation [inference]

regulation of B cell differentiation

regulation of B cell activation [inference]

regulation of B cell differentiation

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of mononuclear cell migration [inference]

negative regulation of neutrophil migration

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

regulation of leukocyte chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

regulation of macrophage chemotaxis [inference]

negative regulation of macrophage chemotaxis

regulation of monocyte chemotaxis [inference]

negative regulation of monocyte chemotaxis

regulation of dendritic cell chemotaxis [inference]

negative regulation of dendritic cell chemotaxis

regulation of mononuclear cell migration [inference]

negative regulation of mononuclear cell migration [inference]

regulation of monocyte chemotaxis [inference]

negative regulation of monocyte chemotaxis

regulation of dendritic cell chemotaxis [inference]

negative regulation of dendritic cell chemotaxis

regulation of neutrophil migration [inference]

negative regulation of neutrophil migration

regulation of macrophage migration [inference]

regulation of macrophage chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of mononuclear cell migration [inference]

negative regulation of neutrophil migration

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of mononuclear cell migration [inference]

negative regulation of neutrophil migration

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

regulation of lymphocyte activation [inference]

regulation of lymphocyte differentiation [inference]

regulation of B cell differentiation

regulation of B cell activation [inference]

regulation of B cell differentiation

negative regulation of multicellular organismal process [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of respiratory burst involved in inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

regulation of B cell differentiation

regulation of biological quality [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

phagosome acidification

regulation of molecular function [inference]

regulation of catalytic activity [inference]

regulation of transferase activity [inference]

regulation of kinase activity

regulation of oxidoreductase activity [inference]

regulation of NAD(P)H oxidase activity

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cell surface	NAS	11313408
membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	32296183 33961781
signaling receptor activity	ISS
signaling receptor activity	IBA
identical protein binding	ISS

GO Hierarchy

molecular function

binding [inference]

protein binding

identical protein binding

molecular transducer activity [inference]

signaling receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

SLAM family member 6

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold

Ortholog

Displaying entries **21 - 30** of 34 in total

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Species	Gene ID	Orthologous MAtrix
Chlorocebus sabaeus	103223747	CHLSB08254
Carlito syrichta	103261107	CARSF03206
Nannospalax galili	103740243	NANGA16035
Rhinopithecus roxellana	104660416	RHIRO30177
Macaca nemestrina	105498151	MACNE23595
Mandrillus leucophaeus	105532288	MANLE36474
Cercocebus atys	105589297	CERAT37056
Aotus nancymaae	105715379	AOTNA24706
Propithecus coquereli	105824437	PROCO15212
Rhinopithecus bieti	108524034	RHIBE30965

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Acknowledgements