GlyCosmos Portal

Submissions

alanyl-tRNA synthetase 2, mitochondrial

Summary

Gene Symbol

AARS2

Organism

Homo sapiens (human)

External Links

NCBI Gene

57505

PubChem

57505

Alliance of Genome Resources

HGNC:21022

Annotation

Keyword

3D-structure
ATP-binding
Aminoacyl-tRNA synthetase
Cardiomyopathy
Disease variant
Metal-binding
Mitochondrion
Neurodegeneration
Premature ovarian failure
Primary mitochondrial disease
Protein biosynthesis
Reference proteome
Transit peptide
Zinc
tRNA-binding

Proteins

Displaying 1 entry
UniProt	Protein Name
Q5JTZ9	Alanyl-tRNA synthetase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
alanyl-tRNA aminoacylation	IBA
mitochondrial alanyl-tRNA aminoacylation	IMP	21549344
aminoacyl-tRNA metabolism involved in translational fidelity	IEA
negative regulation of cGAS/STING signaling pathway	IDA	39322678

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

mitochondrial alanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

mitochondrial alanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

mitochondrial alanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

mitochondrial alanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

mitochondrial alanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

mitochondrial alanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

mitochondrial alanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

mitochondrial alanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

mitochondrial alanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

mitochondrial alanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

mitochondrial alanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

mitochondrial alanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

mitochondrial alanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

mitochondrial alanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

mitochondrial alanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

mitochondrial alanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

mitochondrial alanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial alanyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of response to external stimulus [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cGAS/STING signaling pathway

regulation of biological quality [inference]

regulation of translational fidelity [inference]

aminoacyl-tRNA metabolism involved in translational fidelity

Displaying **all 3** entries
GO Term	Evidence Code	PMID
mitochondrion	IDA	21549344
mitochondrion	IBA
mitochondrion	HTP	34800366

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 7 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
tRNA binding	IEA
aminoacyl-tRNA editing activity	IBA
alanine-tRNA ligase activity	IMP	21549344
alanine-tRNA ligase activity	IBA
protein binding	IPI	32296183

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

carboxylic ester hydrolase activity [inference]

aminoacyl-tRNA editing activity

ligase activity [inference]

ligase activity, forming carbon-oxygen bonds [inference]

aminoacyl-tRNA ligase activity [inference]

alanine-tRNA ligase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

catalytic activity, acting on a tRNA [inference]

aminoacyl-tRNA editing activity

aminoacyl-tRNA ligase activity [inference]

alanine-tRNA ligase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

tRNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Alanine--tRNA ligase

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 9** entries
Gene Ontology
ATP binding
alanine-tRNA ligase activity
alanyl-tRNA aminoacylation
aminoacyl-tRNA editing activity
ligase activity
metal ion binding
nucleotide binding
tRNA aminoacylation
zinc ion binding

Displaying **all 10** entries
InterPro
Alanine-tRNA ligase, class IIc, anti-codon-binding domain superfamily
Alanine-tRNA ligase, class IIc
Alanine-tRNA ligase, eukaryota/bacteria
Alanyl-tRNA synthetase, class IIc, N-terminal
Alanyl-tRNA synthetase, class IIc, core domain
Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)
DHHA1 domain
Threonyl/alanyl tRNA synthetase, SAD
Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily
Translation protein, beta-barrel domain superfamily

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0070396	progressive leukoencephalopathy with ovarian failure	Alliance of Genome Resources
DOID:0111479	combined oxidative phosphorylation deficiency 8	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **105** in total

1

2

3

4

5

…

Next ›

Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	16	SGD:S000005862
Danio rerio	10317	ZFIN:ZDB-GENE-041008-213
Danio rerio	38561	ZFIN:ZDB-GENE-041008-213
Danio rerio	57505	ZFIN:ZDB-GENE-041008-213
Danio rerio	93961	ZFIN:ZDB-GENE-041008-213
Mus musculus	224805		MOUSE22128
Saccharomyces cerevisiae S288C	234734	SGD:S000005862
Danio rerio	288161	ZFIN:ZDB-GENE-041008-213
Rattus norvegicus	301254		RATNO42417
Pan troglodytes	462733		PANTR38280

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements