GlyCosmos Portal

Annotation

Keyword

3D-structure
Alternative splicing
DNA repair
DNA-binding
Disease variant
Helicase
Nucleus
Phosphoprotein
Premature ovarian failure
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8IYD8	ATP-dependent RNA helicase FANCM Fanconi anemia-associated polypeptide of 250 kDa Protein Hef ortholog

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
resolution of meiotic recombination intermediates	IMP	20347428
replication fork processing	IMP	20347428
interstrand cross-link repair	IDA	20347429
interstrand cross-link repair	IBA
double-strand break repair via synthesis-dependent strand annealing	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

interstrand cross-link repair

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

interstrand cross-link repair

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

interstrand cross-link repair

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

interstrand cross-link repair

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

interstrand cross-link repair

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

interstrand cross-link repair

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

interstrand cross-link repair

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

cellular process [inference]

cell cycle process [inference]

meiotic cell cycle process [inference]

meiosis I cell cycle process [inference]

resolution of meiotic recombination intermediates

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

interstrand cross-link repair

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

interstrand cross-link repair

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

interstrand cross-link repair

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

interstrand cross-link repair

reproductive process [inference]

meiotic cell cycle process [inference]

meiosis I cell cycle process [inference]

resolution of meiotic recombination intermediates

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

interstrand cross-link repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

interstrand cross-link repair

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

regulation of post-translational protein modification [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein ubiquitination [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

regulation of protein monoubiquitination [inference]

positive regulation of protein monoubiquitination

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

regulation of post-translational protein modification [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein ubiquitination [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

regulation of protein monoubiquitination [inference]

positive regulation of protein monoubiquitination

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

regulation of post-translational protein modification [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein ubiquitination [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

regulation of protein monoubiquitination [inference]

positive regulation of protein monoubiquitination

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
chromatin	IDA	20347429
nucleoplasm	TAS
nucleoplasm	IDA
cytosol	TAS
Fanconi anaemia nuclear complex	IDA	20347428 20347429

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-DNA complex [inference]

chromatin

nuclear protein-containing complex [inference]

cellular anatomical entity [inference]

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
four-way junction DNA binding	IBA
chromatin binding	IDA	20347429
RNA helicase activity	IEA
nuclease activity	IEA
protein binding	IPI	17289582 20347429 23932590 25416956 32296183 32769987 33961781

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

nuclease activity

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

catalytic activity, acting on a nucleic acid [inference]

helicase activity [inference]

DNA helicase activity [inference]

RNA helicase activity

catalytic activity, acting on DNA [inference]

ATP-dependent activity, acting on DNA [inference]

DNA helicase activity [inference]

catalytic activity, acting on RNA [inference]

RNA helicase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding [inference]

chromatin binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

DNA secondary structure binding [inference]

four-way junction DNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

helicase activity [inference]

DNA helicase activity [inference]

RNA helicase activity

ATP-dependent activity, acting on DNA [inference]

DNA helicase activity [inference]

ATP-dependent activity, acting on RNA [inference]

RNA helicase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Fanconi anemia group M protein

Functional Category

L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
ATP binding
DNA duplex unwinding
DNA repair
double-strand break repair via synthesis-dependent strand annealing
four-way junction DNA binding
hydrolase activity
interstrand cross-link repair
nucleotide binding

Displaying **all 6** entries
InterPro
DEAD/DEAH box helicase domain
FANCM, DEAH-box helicase domain
FANCM/Mph1-like, insert domain
Helicase superfamily 1/2, ATP-binding domain
Helicase, C-terminal domain-like
P-loop containing nucleoside triphosphate hydrolase

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0080872	primary ovarian insufficiency 15	Alliance of Genome Resources
DOID:0111916	spermatogenic failure 28	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 50** of 55 in total

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Species	Gene ID	Orthologous MAtrix
Propithecus coquereli	105809203	PROCO24606
Dipodomys ordii	105982579	DIPOR05278
Salmo salar	106610649	SALSA138513
Ictalurus punctatus	108269866	ICTPU35057
Rhinopithecus bieti	108537060	RHIBE38579
Crocodylus porosus	109324577	CROPO26790
Vulpes vulpes	112921475	VULVU14335
Bos indicus x Bos taurus	113879947	BOBOX36521
Salmo trutta	115162594	SALTR57325
Gadus morhua	115544181	GADMO47559

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements