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proline dehydrogenase 2

Summary

Gene Symbol

PRODH2

Organism

Homo sapiens (human)

External Links

NCBI Gene

58510

PubChem

58510

Alliance of Genome Resources

HGNC:17325

Annotation

Keyword

Acetylation
FAD
Oxidoreductase
Proline metabolism
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9UF12	Kidney and liver proline oxidase 1 Probable proline dehydrogenase 2 Probable proline oxidase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
proline catabolic process to glutamate	IBA
proline catabolic process	TAS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

glutamate metabolic process [inference]

proline catabolic process to glutamate

amide catabolic process [inference]

proline catabolic process to glutamate

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process [inference]

proline catabolic process to glutamate

proline metabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

catabolic process [inference]

amide catabolic process [inference]

proline catabolic process to glutamate

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process [inference]

proline catabolic process to glutamate

proline metabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

dicarboxylic acid metabolic process [inference]

glutamate metabolic process [inference]

proline catabolic process to glutamate

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process [inference]

proline catabolic process to glutamate

proline metabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process [inference]

proline catabolic process to glutamate

proline metabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

dicarboxylic acid metabolic process [inference]

glutamate metabolic process [inference]

proline catabolic process to glutamate

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process [inference]

proline catabolic process to glutamate

proline metabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

dicarboxylic acid metabolic process [inference]

glutamate metabolic process [inference]

proline catabolic process to glutamate

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process [inference]

proline catabolic process to glutamate

proline metabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process [inference]

proline catabolic process to glutamate

proline metabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

dicarboxylic acid metabolic process [inference]

glutamate metabolic process [inference]

proline catabolic process to glutamate

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

alpha-amino acid catabolic process [inference]

glutamine family amino acid catabolic process [inference]

proline catabolic process

proline catabolic process to glutamate

Displaying **all 2** entries
GO Term	Evidence Code	PMID
mitochondrial inner membrane	TAS
mitochondrion	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 3** entries
GO Term	Evidence Code	PMID
FAD binding	IBA
proline dehydrogenase activity	IBA TAS
oxidoreductase activity, acting on the CH-NH group of donors	IDA	25697095

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on the CH-NH group of donors

oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor [inference]

proline dehydrogenase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding [inference]

FAD binding

ion binding [inference]

anion binding [inference]

flavin adenine dinucleotide binding [inference]

FAD binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding [inference]

FAD binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

PROLINE DEHYDROGENASE

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
FAD binding
oxidoreductase activity
proline catabolic process
proline dehydrogenase activity
proline metabolic process

Displaying **all 3** entries
InterPro
FAD-linked oxidoreductase-like
Proline dehydrogenase domain
Proline oxidase family

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060413	chromosome 22q11.2 deletion syndrome, distal	Alliance of Genome Resources

Ortholog

Displaying entries **51 - 58** of 58 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Salmo trutta	115200976			SALTR100330
Sparus aurata	115570745			SPAAU32308
Chelonoidis abingdonii	116826185			CHEAB30982
Rhinolophus ferrumequinum	117034953			RHIFE00995
Scophthalmus maximus	118287419			SCOMX12439
Balaenoptera musculus	118884847			BALMU16759
Ursus americanus	123793900			URSAM00256
Pongo pygmaeus	129019526	9600_0:0048b2

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GlyCosmos Portal v4.1.0

Last updated: December 9, 2024