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hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2

Summary

Gene Symbol

HCN2

Organism

Homo sapiens (human)

External Links

NCBI Gene

610

PubChem

610

Alliance of Genome Resources

HGNC:4846

Annotation

Keyword

3D-structure
Ammonia transport
Cell membrane
Disease variant
Epilepsy
Glycoprotein
Ligand-gated ion channel
Methylation
Palmitate
Phosphoprotein
Potassium channel
Reference proteome
Sodium channel
Transmembrane helix
Voltage-gated channel
cAMP-binding

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9UL51	Brain cyclic nucleotide-gated channel 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
cellular response to cGMP	IDA	22748890
ammonium transmembrane transport	ISS
potassium ion import across plasma membrane	IDA	10228147
cellular response to cAMP	IDA	10228147 22748890
potassium ion transmembrane transport	IBA IDA IMP	10228147 22748890

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to oxygen-containing compound [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

potassium ion transmembrane transport

potassium ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

potassium ion transmembrane transport

potassium ion import across plasma membrane

ammonium transmembrane transport

inorganic cation import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

response to stimulus [inference]

response to endogenous stimulus [inference]

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

response to cGMP [inference]

cellular response to cGMP

cellular response to organonitrogen compound [inference]

response to organic cyclic compound [inference]

response to purine-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

response to cGMP [inference]

cellular response to cGMP

cellular response to organic cyclic compound [inference]

response to organophosphorus [inference]

response to cAMP [inference]

cellular response to cAMP

response to cGMP [inference]

cellular response to cGMP

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to oxygen-containing compound [inference]

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

response to cGMP [inference]

cellular response to cGMP

cellular response to organonitrogen compound [inference]

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

response to oxygen-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

response to cGMP [inference]

cellular response to cGMP

cellular response to oxygen-containing compound [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to oxygen-containing compound [inference]

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport [inference]

potassium ion transmembrane transport

potassium ion import across plasma membrane

sodium ion transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

potassium ion transmembrane transport

potassium ion import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

potassium ion transmembrane transport

potassium ion import across plasma membrane

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

potassium ion transmembrane transport

potassium ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

potassium ion transmembrane transport

potassium ion import across plasma membrane

ammonium transmembrane transport

inorganic cation import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

nitrogen compound transport [inference]

ammonium transmembrane transport

import into cell [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling

regulation of cellular process [inference]

regulation of membrane depolarization

regulation of biological quality [inference]

regulation of membrane potential

regulation of membrane depolarization

membrane depolarization [inference]

membrane depolarization during action potential [inference]

membrane depolarization during cardiac muscle cell action potential

Displaying **all 5** entries
GO Term	Evidence Code	PMID
voltage-gated potassium channel complex	TAS	9630217
HCN channel complex	IBA IDA	10228147
plasma membrane	IDA TAS	10228147 22748890
dendrite	IBA
axon	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

voltage-gated potassium channel complex

HCN channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex [inference]

voltage-gated potassium channel complex

HCN channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex [inference]

voltage-gated potassium channel complex

HCN channel complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	26966193
voltage-gated sodium channel activity	IMP	22748890
identical protein binding	IPI	22006928
intracellular cAMP-activated cation channel activity	IDA	10228147
cAMP binding	IEA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

sodium channel activity [inference]

voltage-gated sodium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

ligand-gated monoatomic cation channel activity [inference]

intracellular cyclic nucleotide-activated monoatomic cation channel activity [inference]

intracellular cAMP-activated cation channel activity

ligand-gated monoatomic ion channel activity [inference]

intracellular ligand-gated monoatomic ion channel activity [inference]

intracellular cyclic nucleotide-activated monoatomic cation channel activity [inference]

intracellular cAMP-activated cation channel activity

cyclic nucleotide-activated monoatomic ion channel activity [inference]

intracellular cyclic nucleotide-activated monoatomic cation channel activity [inference]

intracellular cAMP-activated cation channel activity

ligand-gated monoatomic cation channel activity [inference]

intracellular cyclic nucleotide-activated monoatomic cation channel activity [inference]

intracellular cAMP-activated cation channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

sodium channel activity [inference]

voltage-gated sodium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

ligand-gated monoatomic cation channel activity [inference]

intracellular cyclic nucleotide-activated monoatomic cation channel activity [inference]

intracellular cAMP-activated cation channel activity

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

sodium channel activity [inference]

voltage-gated sodium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

ligand-gated monoatomic cation channel activity [inference]

intracellular cyclic nucleotide-activated monoatomic cation channel activity [inference]

intracellular cAMP-activated cation channel activity

ligand-gated monoatomic ion channel activity [inference]

intracellular ligand-gated monoatomic ion channel activity [inference]

intracellular cyclic nucleotide-activated monoatomic cation channel activity [inference]

intracellular cAMP-activated cation channel activity

cyclic nucleotide-activated monoatomic ion channel activity [inference]

intracellular cyclic nucleotide-activated monoatomic cation channel activity [inference]

intracellular cAMP-activated cation channel activity

ligand-gated monoatomic cation channel activity [inference]

intracellular cyclic nucleotide-activated monoatomic cation channel activity [inference]

intracellular cAMP-activated cation channel activity

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

intracellular ligand-gated monoatomic ion channel activity [inference]

intracellular cyclic nucleotide-activated monoatomic cation channel activity [inference]

intracellular cAMP-activated cation channel activity

cyclic nucleotide-activated monoatomic ion channel activity [inference]

intracellular cyclic nucleotide-activated monoatomic cation channel activity [inference]

intracellular cAMP-activated cation channel activity

ligand-gated monoatomic cation channel activity [inference]

intracellular cyclic nucleotide-activated monoatomic cation channel activity [inference]

intracellular cAMP-activated cation channel activity

salt transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

binding [inference]

protein binding

identical protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

cyclic nucleotide binding [inference]

cAMP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

ion binding [inference]

anion binding [inference]

cAMP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

cyclic nucleotide binding [inference]

cAMP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cyclic nucleotide-gated cation channel

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
monoatomic ion channel activity
monoatomic ion transport

Displaying **all 4** entries
InterPro
Cyclic nucleotide-binding domain superfamily
Cyclic nucleotide-binding domain
Ion transport domain
RmlC-like jelly roll fold

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0111310	familial febrile seizures 2	Alliance of Genome Resources
DOID:11832	visual epilepsy	Alliance of Genome Resources
DOID:2723	dermatitis	Alliance of Genome Resources
DOID:9471	meningitis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 25 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	15166		MGI:1298210	MOUSE02614
Drosophila melanogaster	36589		FB:FBgn0263397
Rattus norvegicus	114244		RGD:620689	RATNO39549
Danio rerio	557285		ZFIN:ZDB-GENE-030131-8228
Pan troglodytes	749873	9598_0:004e61
Callithrix jacchus	100385316			CALJA23098
Macaca mulatta	100425114			MACMU19497
Pongo abelii	100449474	9601_0:0047b3		PONAB14954
Pan paniscus	100969664	9597_0:004cd7
Felis catus	101090996			FELCA04062

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements