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Guidelines

MIRAGE

ribosomal protein L8

Summary

Gene Symbol

RPL8

Organism

Homo sapiens (human)

External Links

NCBI Gene

6132

PubChem

6132

Alliance of Genome Resources

HGNC:10368

Annotation

Keyword

3D-structure
Cytoplasm
Direct protein sequencing
Hydroxylation
Isopeptide bond
Proteomics identification
Reference proteome
Ribosomal protein
Ubl conjugation
rRNA-binding

Proteins

Displaying 1 entry
UniProt	Protein Name
P62917	60S ribosomal protein L8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cytoplasmic translation	NAS	25901680
cytoplasmic translation	IC	23636399
cytoplasmic translation	IDA	25957688
cytoplasmic translation	IBA
translation	NAS	12962325

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

cytoplasmic translation

amide metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

cytoplasmic translation

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

cytoplasmic translation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

cytoplasmic translation

protein metabolic process [inference]

cytoplasmic translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

cytoplasmic translation

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

cytoplasmic translation

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

cytoplasmic translation

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

cytoplasmic translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

cytoplasmic translation

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

cytoplasmic translation

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

cytoplasmic translation

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

cytoplasmic translation

primary metabolic process [inference]

protein metabolic process [inference]

cytoplasmic translation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

cytoplasmic translation

protein metabolic process [inference]

cytoplasmic translation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

cytoplasmic translation

protein metabolic process [inference]

cytoplasmic translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

cytoplasmic translation

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

cytoplasmic translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

cytoplasmic translation

cellular process [inference]

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

cytoplasmic translation

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

cytoplasmic translation

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

cytoplasmic translation

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
nucleoplasm	TAS
cytoplasm	NAS	25901680
cytosol	TAS
focal adhesion	HDA	21423176
postsynaptic density	EXP	21170055

GO Hierarchy

cellular component

protein-containing complex [inference]

ribonucleoprotein complex [inference]

ribosomal subunit [inference]

large ribosomal subunit [inference]

cytosolic large ribosomal subunit

cellular anatomical entity [inference]

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

ribosome [inference]

cytosolic ribosome

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

ribosome [inference]

cytosolic ribosome

postsynaptic specialization [inference]

postsynaptic density

postsynapse

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
RNA binding	IBA
RNA binding	HDA	22658674 22681889
structural constituent of ribosome	NAS	12962325
structural constituent of ribosome	IDA	23636399 32669547
structural constituent of ribosome	IBA

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of ribosome

binding [inference]

protein binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

rRNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Ribosomal protein

Functional Category

J: Translation, ribosomal structure and biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
cytoplasmic translation

Displaying **all 8** entries
InterPro
Large ribosomal subunit protein uL2, C-terminal
Large ribosomal subunit protein uL2, RNA-binding domain
Large ribosomal subunit protein uL2, conserved site
Large ribosomal subunit protein uL2, domain 2
Large ribosomal subunit protein uL2, domain 3
Large ribosomal subunit protein uL2
Nucleic acid-binding, OB-fold
Translation protein SH3-like domain superfamily

Ortholog

Displaying entries **1 - 10** of 83 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	6132	Xenbase:XB-GENE-482209
Mus musculus	26961		MOUSE16580
Rattus norvegicus	26962		RATNO39698
Danio rerio	393686		DANRE44510
Pan troglodytes	464473		PANTR43516
Canis lupus familiaris	475130		CANLF03335
Rattus norvegicus	499374		RATNO15952
Bos taurus	535056		BOVIN05503
Macaca mulatta	708535		MACMU44155
Monodelphis domestica	100013514		MONDO20530

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

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Last updated: December 8, 2025