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MIRAGE
brain derived neurotrophic factor
Summary
- Gene Symbol
-
- BDNF
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative promoter usage
- Alternative splicing
- Cleavage on pair of basic residues
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycoprotein
- Growth factor
- Reference proteome
- Secreted
- Signal
- Proteins
| UniProt | Protein Name |
|---|---|
| P23560 |
|
| A0A0E3SU01 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| negative regulation of neuron apoptotic process | ||
| collateral sprouting | ||
| positive regulation of collateral sprouting | ||
| neuron projection morphogenesis | ||
| modulation of chemical synaptic transmission |
GO Hierarchy
biological process
cellular process [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of signaling [inference]
positive regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
regulation of cellular component organization [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular region | ||
| extracellular space | ||
| cytoplasm | ||
| endoplasmic reticulum lumen | ||
| synaptic vesicle |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| nerve growth factor receptor binding | ||
| protein binding | ||
| growth factor activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Brain-derived neurotrophic factor
- Functional Category
-
- E: Amino acid transport and metabolism
- G: Carbohydrate transport and metabolism
- T: Signal transduction mechanisms
| InterPro |
|---|
| Brain-derived neurotrophic factor |
| Cystine-knot cytokine |
| Nerve growth factor conserved site |
| Nerve growth factor-like |
| Nerve growth factor-related |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050848 | obstructive sleep apnea | |
| DOID:0060731 | congenital central hypoventilation syndrome | |
| DOID:0080855 | Parkinsonism | |
| DOID:10652 | Alzheimer's disease | |
| DOID:10933 | obsessive-compulsive disorder | |
| DOID:12858 | Huntington's disease | |
| DOID:13399 | color blindness | |
| DOID:1561 | cognitive disorder | |
| DOID:1686 | glaucoma | |
| DOID:1824 | status epilepticus |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 751584 | TAEGU25191 | ||
| 100081142 | ORNAN18725 | ||
| 100409412 | CALJA03887 | ||
| 100447350 | PONAB03621 | ||
| 100467162 | AILME11567 | ||
| 100547785 | MELGA10401 | ||
| 100564408 | ANOCA15405 | ||
| 100594402 | NOMLE10416 | ||
| 100691267 | ORENI34766 | ||
| 100730257 | CAVPO19978 |
