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MIRAGE
Neurotrophic factor BDNF precursor form
Summary
- UniProt ID
- P23560
- Gene Symbol
-
- BDNF
- Gene ID
- 627
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative promoter usage
- Alternative splicing
- Cleavage on pair of basic residues
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycoprotein
- Growth factor
- Reference proteome
- Secreted
- Signal
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular region |
| extracellular space |
| cytoplasm |
| axon |
| dendrite |
| endoplasmic reticulum lumen |
| perinuclear region of cytoplasm |
| synaptic vesicle |
| GO Term |
|---|
| growth factor activity |
| nerve growth factor receptor binding |
Sequence
MTILFLTMVISYFGCMKAAPMKEANIRGQGGLAYPGVRTHGTLESVNGPKAGSRGLTSLADTFEHVIEELLDEDQKVRPNEENNKDADLYTSRVMLSSQVPLEPPLLFLLEEYKNYLDAANMSMRVRRHSDPARRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQYFYETKCNPMGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKRIGWRFIRIDTSCVCTLTIKRGR
Glycosylation Sites
G62765YT
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Activated NTRK2 signals through CDK5 | Homo sapiens |
| Activated NTRK2 signals through FRS2 and FRS3 | Homo sapiens |
| Activated NTRK2 signals through FYN | Homo sapiens |
| Activated NTRK2 signals through PI3K | Homo sapiens |
| Activated NTRK2 signals through PLCG1 | Homo sapiens |
| Activated NTRK2 signals through RAS | Homo sapiens |
| BDNF activates NTRK2 (TRKB) signaling | Homo sapiens |
| Constitutive Signaling by Aberrant PI3K in Cancer | Homo sapiens |
| MECP2 regulates transcription of neuronal ligands | Homo sapiens |
| NPAS4 regulates expression of target genes | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050848 | obstructive sleep apnea | |
| DOID:0060731 | congenital central hypoventilation syndrome | |
| DOID:0080855 | Parkinsonism | |
| DOID:10652 | Alzheimer's disease | |
| DOID:10933 | obsessive-compulsive disorder | |
| DOID:12858 | Huntington's disease | |
| DOID:13399 | color blindness | |
| DOID:1561 | cognitive disorder | |
| DOID:1686 | glaucoma | |
| DOID:1824 | status epilepticus |
