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brain derived neurotrophic factor

Summary

Gene Symbol

BDNF

Organism

Homo sapiens (human)

External Links

NCBI Gene

627

PubChem

627

Alliance of Genome Resources

HGNC:1033

Annotation

Keyword

3D-structure
Alternative promoter usage
Alternative splicing
Cleavage on pair of basic residues
Direct protein sequencing
Disease variant
Disulfide bond
Glycoprotein
Growth factor
Reference proteome
Secreted
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P23560	Abrineurin
A0A0E3SU01

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
transmembrane receptor protein tyrosine kinase signaling pathway	IBA
nervous system development	TAS	2236018
axon guidance	TAS	19036963
synapse assembly	IDA	19036963
negative regulation of myotube differentiation	ISS

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

brain-derived neurotrophic factor receptor signaling pathway

neurotrophin signaling pathway [inference]

nerve growth factor signaling pathway

cell growth [inference]

developmental cell growth [inference]

collateral sprouting

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

synapse assembly

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly

synapse organization [inference]

synapse assembly

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

anatomical structure development [inference]

nerve development

system development [inference]

nervous system development

growth [inference]

cell growth [inference]

developmental cell growth [inference]

collateral sprouting

developmental growth [inference]

developmental cell growth [inference]

collateral sprouting

developmental growth involved in morphogenesis [inference]

collateral sprouting

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

regulation of brain-derived neurotrophic factor receptor signaling pathway [inference]

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to cell surface

regulation of growth [inference]

regulation of cell growth [inference]

positive regulation of cell growth [inference]

positive regulation of collateral sprouting

regulation of extent of cell growth [inference]

regulation of collateral sprouting [inference]

positive regulation of collateral sprouting

positive regulation of growth [inference]

positive regulation of cell growth [inference]

positive regulation of collateral sprouting

positive regulation of developmental growth [inference]

positive regulation of collateral sprouting

regulation of developmental growth [inference]

positive regulation of developmental growth [inference]

positive regulation of collateral sprouting

regulation of collateral sprouting [inference]

positive regulation of collateral sprouting

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

positive regulation of growth [inference]

positive regulation of cell growth [inference]

positive regulation of collateral sprouting

positive regulation of developmental growth [inference]

positive regulation of collateral sprouting

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

positive regulation of cell growth [inference]

positive regulation of collateral sprouting

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of collateral sprouting

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

positive regulation of axonogenesis [inference]

positive regulation of collateral sprouting

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of collateral sprouting

positive regulation of developmental growth [inference]

positive regulation of collateral sprouting

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of collateral sprouting

positive regulation of synapse assembly

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of collateral sprouting

positive regulation of synapse assembly

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of myotube differentiation

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of myotube differentiation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

regulation of brain-derived neurotrophic factor receptor signaling pathway [inference]

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of axonogenesis [inference]

regulation of collateral sprouting [inference]

positive regulation of collateral sprouting

positive regulation of axonogenesis [inference]

positive regulation of collateral sprouting

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of myotube differentiation

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of collateral sprouting

regulation of muscle cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of myotube differentiation

regulation of striated muscle cell differentiation [inference]

regulation of myotube differentiation [inference]

negative regulation of myotube differentiation

negative regulation of striated muscle cell differentiation [inference]

negative regulation of myotube differentiation

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of collateral sprouting

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of collateral sprouting

regulation of developmental growth [inference]

positive regulation of developmental growth [inference]

positive regulation of collateral sprouting

regulation of collateral sprouting [inference]

positive regulation of collateral sprouting

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of myotube differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of collateral sprouting

positive regulation of developmental growth [inference]

positive regulation of collateral sprouting

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of collateral sprouting

positive regulation of synapse assembly

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of collateral sprouting

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of collateral sprouting

positive regulation of synapse assembly

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

brain-derived neurotrophic factor receptor signaling pathway

neurotrophin signaling pathway [inference]

nerve growth factor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

regulation of brain-derived neurotrophic factor receptor signaling pathway [inference]

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

regulation of neuron apoptotic process [inference]

negative regulation of neuron apoptotic process

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

positive regulation of synapse assembly

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of myotube differentiation

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of collateral sprouting

regulation of muscle cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of myotube differentiation

regulation of striated muscle cell differentiation [inference]

regulation of myotube differentiation [inference]

negative regulation of myotube differentiation

negative regulation of striated muscle cell differentiation [inference]

negative regulation of myotube differentiation

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of collateral sprouting

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of collateral sprouting

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of brain-derived neurotrophic factor receptor signaling pathway

positive regulation of cell growth [inference]

positive regulation of collateral sprouting

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of collateral sprouting

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

positive regulation of axonogenesis [inference]

positive regulation of collateral sprouting

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of myotube differentiation

regulation of cellular component organization [inference]

regulation of cell growth [inference]

positive regulation of cell growth [inference]

positive regulation of collateral sprouting

regulation of extent of cell growth [inference]

regulation of collateral sprouting [inference]

positive regulation of collateral sprouting

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

positive regulation of axonogenesis [inference]

positive regulation of collateral sprouting

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

positive regulation of neuron projection development

regulation of axonogenesis [inference]

regulation of collateral sprouting [inference]

positive regulation of collateral sprouting

positive regulation of axonogenesis [inference]

positive regulation of collateral sprouting

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

positive regulation of synapse assembly

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

positive regulation of axonogenesis [inference]

positive regulation of collateral sprouting

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

positive regulation of synapse assembly

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to cell surface

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of collateral sprouting

positive regulation of synapse assembly

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of collateral sprouting

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of collateral sprouting

positive regulation of synapse assembly

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of binding [inference]

positive regulation of protein binding [inference]

positive regulation of receptor binding

regulation of binding [inference]

regulation of protein binding [inference]

positive regulation of protein binding [inference]

positive regulation of receptor binding

regulation of receptor binding [inference]

positive regulation of receptor binding

positive regulation of binding [inference]

positive regulation of protein binding [inference]

positive regulation of receptor binding

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
axon	IBA
dendrite	IBA
perinuclear region of cytoplasm	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

perinuclear region of cytoplasm

Displaying **all 3** entries
GO Term	Evidence Code	PMID
nerve growth factor receptor binding	IBA
protein binding	IPI	10631974 25241761 29997244 32296183 32814053 33961781 7703225
growth factor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

cytokine receptor binding [inference]

neurotrophin receptor binding [inference]

nerve growth factor receptor binding

tumor necrosis factor receptor superfamily binding [inference]

death receptor binding [inference]

nerve growth factor receptor binding

receptor ligand activity [inference]

growth factor activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

growth factor activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

growth factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Brain-derived neurotrophic factor

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying entries **1 - 10** of 14 in total

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Gene Ontology
growth factor activity
memory
modulation of chemical synaptic transmission
negative regulation of neuron apoptotic process
nerve development
nerve growth factor receptor binding
nerve growth factor signaling pathway
neuron projection morphogenesis
peripheral nervous system development
positive regulation of collateral sprouting

Displaying **all 5** entries
InterPro
Brain-derived neurotrophic factor
Cystine-knot cytokine
Nerve growth factor conserved site
Nerve growth factor-like
Nerve growth factor-related

Disease

Disease Ontology

Displaying entries **1 - 10** of 15 in total

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DO ID	Disease Name	Source
DOID:0050848	obstructive sleep apnea	Alliance of Genome Resources
DOID:0060731	congenital central hypoventilation syndrome	Alliance of Genome Resources
DOID:0080855	Parkinsonism	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:10933	obsessive-compulsive disorder	Alliance of Genome Resources
DOID:12858	Huntington's disease	Alliance of Genome Resources
DOID:13399	color blindness	Alliance of Genome Resources
DOID:1561	cognitive disorder	Alliance of Genome Resources
DOID:1686	glaucoma	Alliance of Genome Resources
DOID:1824	status epilepticus	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 71 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	627	Xenbase:XB-GENE-955554
Mus musculus	12064	Xenbase:XB-GENE-955554	MOUSE34601
Rattus norvegicus	24225	Xenbase:XB-GENE-955554	RATNO27066
Danio rerio	58118		DANRE39504
Sus scrofa	397495		PIGXX17500
Felis catus	493690		FELCA24057
Pan troglodytes	503511		PANTR02543
Monodelphis domestica	554233		MONDO28037
Bos taurus	617701		BOVIN07322
Macaca mulatta	701245		MACMU09565

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements