mitogen-activated protein kinase kinase 4

Summary
Gene Symbol
  • MAP2K4
Organism
Homo sapiens (human)
NCBI Gene
6416
PubChem
6416
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • ATP-binding
  • Acetylation
  • Alternative splicing
  • Apoptosis
  • Cytoplasm
  • Methylation
  • Nucleus
  • Phosphoprotein
  • Reference proteome
  • Serine/threonine-protein kinase
  • Stress response
  • Tyrosine-protein kinase
Proteins
Displaying 1 entry
UniProt Protein Name
P45985
  • JNK-activating kinase 1
  • MAPK/ERK kinase 4
  • SAPK/ERK kinase 1
  • Stress-activated protein kinase kinase 1
  • c-Jun N-terminal kinase kinase 1
Gene Ontology (GO)
Displaying entries 1 - 5 of 17 in total
GO Term Evidence Code PMID
MAPK cascade
protein phosphorylation
signal transduction
JNK cascade
response to wounding
GO Hierarchy
GO Hierarchy
OrthoDB (Group)
Group level
Eukaryota
Group Name
dual specificity mitogen-activated
Functional Category
  • E: Amino acid transport and metabolism
  • Q: Secondary metabolites biosynthesis, transport and catabolism
  • T: Signal transduction mechanisms
Disease
Disease Ontology
Displaying all 7 entries
DO ID Disease Name Source
DOID:0050933 ovarian serous carcinoma
DOID:11054 urinary bladder cancer
DOID:1324 lung cancer
DOID:1793 pancreatic cancer
DOID:3908 lung non-small cell carcinoma
DOID:9256 colorectal cancer
DOID:9261 nasopharynx carcinoma

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025