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MIRAGE
sonic hedgehog signaling molecule
Summary
- Gene Symbol
-
- SHH
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Autocatalytic cleavage
- Calcium
- Cell membrane
- Developmental protein
- Direct protein sequencing
- Disease variant
- Endoplasmic reticulum
- Glycoprotein
- Golgi apparatus
- Holoprosencephaly
- Metal-binding
- Microphthalmia
- Palmitate
- Protease
- Reference proteome
- Secreted
- Signal
- Transferase
- Zinc
- Proteins
| UniProt | Protein Name |
|---|---|
| Q15465 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| positive regulation of kidney smooth muscle cell differentiation | ||
| positive regulation of striated muscle cell differentiation | ||
| hair follicle morphogenesis | ||
| metanephric collecting duct development | ||
| cell fate specification |
GO Hierarchy
- positive regulation of cell division
- positive regulation of cell division
biological process
metabolic process [inference]
cellular process [inference]
reproductive process [inference]
multicellular organismal process [inference]
developmental process [inference]
anatomical structure morphogenesis [inference]
anatomical structure development [inference]
response to stimulus [inference]
localization [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
negative regulation of immune system process [inference]
positive regulation of immune system process [inference]
regulation of leukocyte activation [inference]
negative regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
regulation of lymphocyte differentiation [inference]
regulation of lymphocyte proliferation [inference]
regulation of T cell activation [inference]
negative regulation of lymphocyte activation [inference]
regulation of hemopoiesis [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of catabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of nitrogen compound metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
negative regulation of macromolecule metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of RNA metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of signaling [inference]
regulation of localization [inference]
positive regulation of biological process [inference]
positive regulation of immune system process [inference]
positive regulation of metabolic process [inference]
positive regulation of cellular process [inference]
positive regulation of cell population proliferation
positive regulation of cell differentiation [inference]
positive regulation of cell adhesion [inference]
positive regulation of cell activation [inference]
positive regulation of developmental process [inference]
positive regulation of multicellular organismal process [inference]
negative regulation of biological process [inference]
negative regulation of immune system process [inference]
negative regulation of metabolic process [inference]
negative regulation of cellular process [inference]
negative regulation of multicellular organismal process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cell differentiation [inference]
positive regulation of cell differentiation [inference]
regulation of muscle cell differentiation [inference]
regulation of cell development [inference]
positive regulation of developmental process [inference]
regulation of multicellular organismal development [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cell adhesion [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of cell population proliferation
regulation of cell differentiation [inference]
positive regulation of cell differentiation [inference]
regulation of muscle cell differentiation [inference]
regulation of cell development [inference]
positive regulation of cellular process [inference]
positive regulation of cell population proliferation
positive regulation of cell differentiation [inference]
positive regulation of cell adhesion [inference]
positive regulation of cell activation [inference]
negative regulation of cellular process [inference]
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
negative regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
regulation of lymphocyte differentiation [inference]
regulation of lymphocyte proliferation [inference]
regulation of T cell activation [inference]
negative regulation of lymphocyte activation [inference]
negative regulation of cell activation [inference]
positive regulation of cell activation [inference]
regulation of cellular localization [inference]
regulation of multicellular organismal process [inference]
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
negative regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
regulation of lymphocyte differentiation [inference]
regulation of lymphocyte proliferation [inference]
regulation of T cell activation [inference]
negative regulation of lymphocyte activation [inference]
negative regulation of cell activation [inference]
positive regulation of cell activation [inference]
positive regulation of multicellular organismal process [inference]
negative regulation of multicellular organismal process [inference]
regulation of multicellular organismal development [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| endoplasmic reticulum | ||
| plasma membrane | ||
| extracellular space | ||
| extracellular region | ||
| collagen-containing extracellular matrix |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| morphogen activity | ||
| endopeptidase activity | ||
| peptidase activity | ||
| zinc ion binding | ||
| calcium ion binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- hedgehog
- Functional Category
-
- L: Replication, recombination and repair
- T: Signal transduction mechanisms
- X: Mobilome: prophages, transposons
| Gene Ontology |
|---|
| calcium ion binding |
| cell fate specification |
| cell-cell signaling |
| hydrolase activity |
| intein-mediated protein splicing |
| metal ion binding |
| patched binding |
| protein autoprocessing |
| proteolysis |
| regulation of gene expression |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050338 | primary bacterial infectious disease | |
| DOID:0050784 | primary progressive multiple sclerosis | |
| DOID:0060041 | autism spectrum disorder | |
| DOID:0060071 | pre-malignant neoplasm | |
| DOID:0080171 | esophageal atresia/tracheoesophageal fistula | |
| DOID:0080855 | Parkinsonism | |
| DOID:0110875 | holoprosencephaly 3 | |
| DOID:0111380 | solitary median maxillary central incisor | |
| DOID:0111564 | hypoplastic or aplastic tibia with polydactyly | |
| DOID:0111818 | syndactyly type 4 |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 20423 | MGI:98297 | MOUSE45693 | ||
| 29499 | RGD:3673 | RATNO30914 | ||
| 30269 | ZFIN:ZDB-GENE-980526-166 | DANRE40080 | ||
| 30444 | ZFIN:ZDB-GENE-980526-41 | |||
| 42737 | FB:FBgn0004644 | |||
| 180349 | WB:WBGene00001691 | |||
| 180638 | WB:WBGene00006952 | |||
| 186880 | WB:WBGene00001700 | |||
| 398047 | Xenbase:XB-GENE-864913 | |||
| 445636 | CIOIN09955 |
