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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Sonic hedgehog protein
Summary
- UniProt ID
- Q15465
- Gene Symbol
-
- SHH
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Autocatalytic cleavage
- Calcium
- Cell membrane
- Developmental protein
- Direct protein sequencing
- Disease variant
- Endoplasmic reticulum
- Glycoprotein
- Golgi apparatus
- Holoprosencephaly
- Metal-binding
- Microphthalmia
- Palmitate
- Protease
- Reference proteome
- Secreted
- Signal
- Transferase
- Zinc
- Gene Ontology (GO)
| GO Term |
|---|
| axon guidance |
| endocytosis |
| cell-cell signaling |
| pattern specification process |
| ectoderm development |
| neuroblast proliferation |
| central nervous system development |
| hindgut morphogenesis |
| heart development |
| blood coagulation |
| GO Term |
|---|
| cytosol |
| membrane raft |
| endoplasmic reticulum |
| endoplasmic reticulum membrane |
| endoplasmic reticulum lumen |
| cell surface |
| Golgi membrane |
| extracellular region |
| extracellular space |
| Golgi apparatus |
Sequence
MLLLARCLLLVLVSSLLVCSGLACGPGRGFGKRRHPKKLTPLAYKQFIPNVAEKTLGASGRYEGKISRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCSVKAENSVAAKSGGCFPGSATVHLEQGGTKLVKDLSPGDRVLAADDQGRLLYSDFLTFLDRDDGAKKVFYVIETREPRERLLLTAAHLLFVAPHNDSATGEPEASSGSGPPSGGALGPRALFASRVRPGQRVYVVAERDGDRRLLPAAVHSVTLSEEAAGAYAPLTAQGTILINRVLASCYAVIEEHSWAHRAFAPFRLAHALLAALAPARTDRGGDSGGGDRGGGGGRVALTAPGAADAPGAGATAGIHWYSQLLYQIGTWLLDSEALHPLGMAVKSS
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Activation of SMO | Homo sapiens |
| Class B/2 (Secretin family receptors) | Homo sapiens |
| Formation of axial mesoderm | Homo sapiens |
| Formation of lateral plate mesoderm | Homo sapiens |
| HHAT G278V doesn't palmitoylate Hh-Np | Homo sapiens |
| Hedgehog 'on' state | Homo sapiens |
| Hedgehog ligand biogenesis | Homo sapiens |
| Hh mutants are degraded by ERAD | Homo sapiens |
| Ligand-receptor interactions | Homo sapiens |
| Release of Hh-Np from the secreting cell | Homo sapiens |
