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cyclin dependent kinase 15

Summary

Gene Symbol

CDK15

Organism

Homo sapiens (human)

External Links

NCBI Gene

65061

PubChem

65061

Alliance of Genome Resources

HGNC:14434

Annotation

Keyword

ATP-binding
Alternative splicing
Magnesium
Metal-binding
Reference proteome
Serine/threonine-protein kinase

Proteins

Displaying 1 entry
UniProt	Protein Name
Q96Q40	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein Cell division protein kinase 15 Serine/threonine-protein kinase ALS2CR7 Serine/threonine-protein kinase PFTAIRE-2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein phosphorylation	IEA
regulation of cell cycle phase transition	IBA
regulation of cell cycle	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of cell cycle

regulation of cell cycle process [inference]

regulation of cell cycle phase transition

Displaying **all 3** entries
GO Term	Evidence Code	PMID
nucleus	IBA
cytosol	IBA
cytoplasm	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	22939624 23602568 25036637 33961781
protein serine kinase activity	IEA
cyclin binding	IBA
metal ion binding	IEA
protein serine/threonine kinase activity	IDA	24866247

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

cyclin-dependent protein serine/threonine kinase activity

cyclin-dependent protein kinase activity [inference]

cyclin-dependent protein serine/threonine kinase activity

protein serine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

cyclin-dependent protein serine/threonine kinase activity

cyclin-dependent protein kinase activity [inference]

cyclin-dependent protein serine/threonine kinase activity

protein serine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

cyclin-dependent protein serine/threonine kinase activity

cyclin-dependent protein kinase activity [inference]

cyclin-dependent protein serine/threonine kinase activity

protein serine kinase activity

binding [inference]

protein binding

cyclin binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cyclin

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
ATP binding
kinase activity
nucleotide binding
phosphorylation
transferase activity

Displaying **all 4** entries
InterPro
Protein kinase domain
Protein kinase, ATP binding site
Protein kinase-like domain superfamily
Serine/threonine-protein kinase, active site

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0050453	lissencephaly	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 66 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Gorilla gorilla gorilla	101145509	9595_0:000e01	GORGO27032
Octodon degus	101581352		OCTDE04132
Mustela putorius furo	101680006		MUSPF08433
Chrysemys picta bellii	101953844		CHRPI31178
Chinchilla lanigera	102010553		CHILA14716
Macaca fascicularis	102123023		MACFA05802
Capra hircus	102173239		CAPHI20514
Latimeria chalumnae	102357781		LATCH14084
Myotis lucifugus	102442189		MYOLU00914
Astyanax mexicanus	103024335		ASTMX05443

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Annotation

OrthoDB (Group)

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Acknowledgements