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solute carrier family 2 member 1

Summary

Gene Symbol

SLC2A1

Organism

Homo sapiens (human)

External Links

NCBI Gene

6513

PubChem

6513

Alliance of Genome Resources

HGNC:11005

Annotation

Keyword

3D-structure
Acetylation
Cataract
Cell membrane
Direct protein sequencing
Disease variant
Dystonia
Epilepsy
Glycoprotein
Hereditary hemolytic anemia
Intellectual disability
Phosphoprotein
Reference proteome
Sugar transport
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q59GX2	Glucose transporter type 1, erythrocyte/brain
P11166	Glucose transporter type 1, erythrocyte/brain HepG2 glucose transporter

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
response to Thyroglobulin triiodothyronine	IEA
protein-containing complex assembly	IDA	18347014
glucose transmembrane transport	IDA IMP	1429721 18245775 21791420 2211693 23280796 25982116 27078104
female pregnancy	IEA
dehydroascorbic acid transport	IBA

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process

heterocycle metabolic process [inference]

lactone metabolic process [inference]

L-ascorbic acid metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process

vitamin metabolic process [inference]

water-soluble vitamin metabolic process [inference]

L-ascorbic acid metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process

organic cyclic compound metabolic process [inference]

lactone metabolic process [inference]

L-ascorbic acid metabolic process

cellular process [inference]

cell communication [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process

heterocycle metabolic process [inference]

lactone metabolic process [inference]

L-ascorbic acid metabolic process

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular hyperosmotic response

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular hyperosmotic response

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

cellular response to osmotic stress [inference]

cellular hyperosmotic response

transmembrane transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

glucose transmembrane transport

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

import across plasma membrane [inference]

long-chain fatty acid import across plasma membrane

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly

protein-containing complex organization [inference]

protein-containing complex assembly

reproductive process [inference]

multi-organism reproductive process [inference]

female pregnancy

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier

multi-multicellular organism process [inference]

female pregnancy

photoreceptor cell maintenance

developmental process [inference]

anatomical structure development [inference]

cerebral cortex development

system development [inference]

central nervous system development

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to osmotic stress [inference]

hyperosmotic response [inference]

cellular hyperosmotic response

cellular response to osmotic stress [inference]

cellular hyperosmotic response

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular hyperosmotic response

response to starvation [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

response to external stimulus [inference]

response to mechanical stimulus [inference]

cellular response to mechanical stimulus

response to extracellular stimulus [inference]

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

response to starvation [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to mechanical stimulus

response to abiotic stimulus [inference]

response to osmotic stress [inference]

hyperosmotic response [inference]

cellular hyperosmotic response

cellular response to osmotic stress [inference]

cellular hyperosmotic response

response to mechanical stimulus [inference]

cellular response to mechanical stimulus

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

cellular response to osmotic stress [inference]

cellular hyperosmotic response

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to Thyroglobulin triiodothyronine

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular hyperosmotic response

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to oxygen-containing compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular hyperosmotic response

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular hyperosmotic response

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

cellular response to osmotic stress [inference]

cellular hyperosmotic response

localization [inference]

establishment of localization [inference]

transport [inference]

vascular transport [inference]

transport across blood-brain barrier

xenobiotic transport

vitamin transport [inference]

dehydroascorbic acid transport

transmembrane transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

glucose transmembrane transport

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

import across plasma membrane [inference]

long-chain fatty acid import across plasma membrane

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

organic substance transport [inference]

lipid transport [inference]

fatty acid transport [inference]

long-chain fatty acid transport [inference]

long-chain fatty acid import into cell [inference]

long-chain fatty acid import across plasma membrane

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

lipid import into cell [inference]

long-chain fatty acid import into cell [inference]

long-chain fatty acid import across plasma membrane

carbohydrate transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

glucose transmembrane transport

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

organic anion transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

fatty acid transport [inference]

long-chain fatty acid transport [inference]

long-chain fatty acid import into cell [inference]

long-chain fatty acid import across plasma membrane

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

dehydroascorbic acid transport

organic acid transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

fatty acid transport [inference]

long-chain fatty acid transport [inference]

long-chain fatty acid import into cell [inference]

long-chain fatty acid import across plasma membrane

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

import into cell [inference]

long-chain fatty acid import into cell [inference]

long-chain fatty acid import across plasma membrane

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
presynapse	IEA
cortical actin cytoskeleton	IDA	18347014
apical plasma membrane	IBA IDA ISS	18619525 31678436 31791063
blood microparticle	HDA	22516433
plasma membrane	IBA IDA IMP ISS TAS	10227690 18245775 21791420 2211693 23137377 25982116 28112518

GO Hierarchy

cellular component

protein-containing complex [inference]

transporter complex [inference]

glucose transporter complex

cellular anatomical entity [inference]

membrane

plasma membrane

sarcolemma

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

plasma membrane region [inference]

plasma membrane raft [inference]

caveola

membrane microdomain [inference]

membrane raft [inference]

plasma membrane raft [inference]

caveola

Z disc

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

cell-cell contact zone [inference]

intercalated disc

midbody

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus [inference]

germ cell nucleus [inference]

female germ cell nucleus

pronucleus [inference]

female pronucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

cortical cytoskeleton [inference]

cortical actin cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus [inference]

germ cell nucleus [inference]

female germ cell nucleus

pronucleus [inference]

female pronucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

cortical cytoskeleton [inference]

cortical actin cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
long-chain fatty acid transporter activity	IMP	10227690
D-glucose transmembrane transporter activity	IBA IDA IMP TAS	10227690 1714544 18245775 21791420 2211693 25982116 27078104 28993322
xenobiotic transmembrane transporter activity	IEA
protein binding	IPI	18347014 23563491 25910212 25957687 35810171
kinase binding	IEA

GO Hierarchy

molecular function

transporter activity [inference]

lipid transporter activity [inference]

long-chain fatty acid transporter activity

transmembrane transporter activity [inference]

organic anion transmembrane transporter activity [inference]

dehydroascorbic acid transmembrane transporter activity

carbohydrate transmembrane transporter activity [inference]

sugar transmembrane transporter activity [inference]

monosaccharide transmembrane transporter activity [inference]

hexose transmembrane transporter activity [inference]

glucose transmembrane transporter activity

D-glucose transmembrane transporter activity

xenobiotic transmembrane transporter activity

vitamin transmembrane transporter activity [inference]

dehydroascorbic acid transmembrane transporter activity

binding [inference]

protein binding

enzyme binding [inference]

kinase binding

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

solute carrier family 2

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 6** entries
InterPro
Glucose transporter GLUT
MFS transporter superfamily
Major facilitator superfamily domain
Major facilitator, sugar transporter-like
Sugar transporter, conserved site
Sugar/inositol transporter

Disease

Disease Ontology

Displaying entries **1 - 10** of 16 in total

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DO ID	Disease Name	Source
DOID:0060326	myelomeningocele	Alliance of Genome Resources
DOID:0090044	dystonia 9	Alliance of Genome Resources
DOID:0090045	childhood onset GLUT1 deficiency syndrome 2	Alliance of Genome Resources
DOID:0111313	idiopathic generalized epilepsy 12	Alliance of Genome Resources
DOID:10487	Hirschsprung's disease	Alliance of Genome Resources
DOID:10591	pre-eclampsia	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:1459	hypothyroidism	Alliance of Genome Resources
DOID:1825	childhood absence epilepsy	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **112** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	20525	MGI:95755	MOUSE41470
Rattus norvegicus	24778	RGD:3704	RATNO33193
Drosophila melanogaster	35520	FB:FBgn0033047
Drosophila melanogaster	38109	FB:FBgn0264574
Drosophila melanogaster	44268	FB:FBgn0028561
Drosophila melanogaster	44269	FB:FBgn0028562
Caenorhabditis elegans	173525	WB:WBGene00019207
Caenorhabditis elegans	178634	WB:WBGene00019979
Caenorhabditis elegans	186195	WB:WBGene00018779
Bos taurus	282356		BOVIN27163

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OrthoDB (Group)

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Acknowledgements