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cubilin

Summary

Gene Symbol

Cubn

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

65969

PubChem

65969

Alliance of Genome Resources

MGI:1931256

Annotation

Keyword

Calcium
Cell membrane
Cholesterol metabolism
Cleavage on pair of basic residues
Coated pit
Cobalamin
Direct protein sequencing
Disulfide bond
EGF-like domain
Endosome
Glycoprotein
Lysosome
Metal-binding
Phosphoprotein
Protein transport
Reference proteome
Repeat
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9JLB4	Intrinsic factor-cobalamin receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
cholesterol metabolic process	IEA
cobalamin transport	ISO	14576052
establishment of localization in cell	IDA IMP	15616221
response to bacterium	IEP	23012479
lipoprotein transport	IDA	15616221

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

organonitrogen compound metabolic process [inference]

tetrapyrrole metabolic process [inference]

cobalamin metabolic process

cobalamin catabolic process

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

organonitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

catabolic process [inference]

cellular catabolic process [inference]

vitamin catabolic process [inference]

water-soluble vitamin catabolic process [inference]

cobalamin catabolic process

aromatic compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

cellular nitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

heterocycle catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

small molecule catabolic process [inference]

vitamin catabolic process [inference]

water-soluble vitamin catabolic process [inference]

cobalamin catabolic process

organic substance catabolic process [inference]

organic cyclic compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

organonitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

aromatic compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

tetrapyrrole metabolic process [inference]

cobalamin metabolic process

cobalamin catabolic process

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

cellular catabolic process [inference]

vitamin catabolic process [inference]

water-soluble vitamin catabolic process [inference]

cobalamin catabolic process

aromatic compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

cellular nitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

heterocycle catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

heterocycle metabolic process [inference]

tetrapyrrole metabolic process [inference]

cobalamin metabolic process

cobalamin catabolic process

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

heterocycle catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

vitamin metabolic process [inference]

water-soluble vitamin metabolic process [inference]

cobalamin metabolic process

cobalamin catabolic process

water-soluble vitamin catabolic process [inference]

cobalamin catabolic process

vitamin catabolic process [inference]

water-soluble vitamin catabolic process [inference]

cobalamin catabolic process

small molecule catabolic process [inference]

vitamin catabolic process [inference]

water-soluble vitamin catabolic process [inference]

cobalamin catabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

tetrapyrrole metabolic process [inference]

cobalamin metabolic process

cobalamin catabolic process

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

organic cyclic compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

organonitrogen compound metabolic process [inference]

tetrapyrrole metabolic process [inference]

cobalamin metabolic process

cobalamin catabolic process

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

organonitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

organic substance catabolic process [inference]

organic cyclic compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

organonitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

endocytic hemoglobin import into cell

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

aromatic compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

tetrapyrrole metabolic process [inference]

cobalamin metabolic process

cobalamin catabolic process

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

cellular catabolic process [inference]

vitamin catabolic process [inference]

water-soluble vitamin catabolic process [inference]

cobalamin catabolic process

aromatic compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

cellular nitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

heterocycle catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

heterocycle metabolic process [inference]

tetrapyrrole metabolic process [inference]

cobalamin metabolic process

cobalamin catabolic process

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

heterocycle catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

endocytic hemoglobin import into cell

lipoprotein localization [inference]

lipoprotein transport

establishment of protein localization [inference]

protein transport [inference]

establishment of protein localization to organelle [inference]

endocytic hemoglobin import into cell

multicellular organismal process [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

developmental process [inference]

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

response to chemical [inference]

response to nutrient

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

endocytic hemoglobin import into cell

lipoprotein localization [inference]

lipoprotein transport

establishment of protein localization [inference]

protein transport [inference]

establishment of protein localization to organelle [inference]

endocytic hemoglobin import into cell

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

endocytic hemoglobin import into cell

vitamin transport [inference]

cobalamin transport

organic substance transport [inference]

protein transport [inference]

cobalamin transport

nitrogen compound transport [inference]

protein transport [inference]

cobalamin transport

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis

endocytic hemoglobin import into cell

establishment of protein localization [inference]

protein transport [inference]

establishment of protein localization to organelle [inference]

endocytic hemoglobin import into cell

establishment of localization in cell

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

endocytic hemoglobin import into cell

lipoprotein localization [inference]

lipoprotein transport

establishment of protein localization [inference]

protein transport [inference]

establishment of protein localization to organelle [inference]

endocytic hemoglobin import into cell

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
coated vesicle	ISO
membrane	ISO
Golgi apparatus	IDA	15616221
endocytic vesicle	IDA ISO	15616221
protein-containing complex	ISO

GO Hierarchy

cellular component

protein-containing complex

receptor complex

cellular anatomical entity [inference]

cytoplasm

membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endocytic vesicle membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endocytic vesicle membrane

plasma membrane region [inference]

cell projection membrane [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

vacuolar lumen [inference]

lysosomal lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

apical part of cell

cluster of actin-based cell projections [inference]

brush border

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	11856751
hemoglobin binding	ISO
cobalamin binding	IEA
identical protein binding	ISO
signaling receptor activity	TAS	10766831

GO Hierarchy

molecular function

binding [inference]

protein binding

hemoglobin binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

small molecule binding [inference]

vitamin binding [inference]

cobalamin binding

heterocyclic compound binding [inference]

cobalamin binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

cobalamin binding

cargo receptor activity

molecular transducer activity [inference]

signaling receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

cubilin

Functional Category

G: Carbohydrate transport and metabolism
I: Lipid transport and metabolism
J: Translation, ribosomal structure and biogenesis

Displaying **all 2** entries
Gene Ontology
calcium ion binding
metal ion binding

Displaying **all 2** entries
InterPro
CUB domain
Spermadhesin, CUB domain superfamily

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:10591	pre-eclampsia	Alliance of Genome Resources
DOID:3393	coronary artery disease	Alliance of Genome Resources
DOID:557	kidney disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **116** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	8029		HGNC:2548	HUMAN00415
Drosophila melanogaster	39334		FB:FBgn0259140
Rattus norvegicus	80848	10116_1:004d17	RGD:68355	RATNO12306
Caenorhabditis elegans	179729		WB:WBGene00013855
Drosophila melanogaster	326235		FB:FBgn0052702
Canis lupus familiaris	403767			CANLF06533
Pan troglodytes	450327			PANTR00240
Bos taurus	523202			BOVIN04467
Macaca mulatta	705162			MACMU44856
Monodelphis domestica	100026923			MONDO34213

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements