GlyCosmos Portal

Annotation

Keyword

3D-structure
Acetylation
Acyltransferase
Alternative splicing
Cholesterol metabolism
Disulfide bond
Endoplasmic reticulum
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P35610	Acyl-coenzyme A:cholesterol acyltransferase 1 Cholesterol acyltransferase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
very-low-density lipoprotein particle assembly	IMP	15308631
macrophage derived foam cell differentiation	IMP NAS	15353128 18971559 8407899
cholesterol storage	IMP	8407899
low-density lipoprotein particle clearance
cholesterol homeostasis	IDA TAS	11401500 32433614

GO Hierarchy

biological process

metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cellular process [inference]

cellular developmental process [inference]

cell differentiation [inference]

foam cell differentiation [inference]

macrophage derived foam cell differentiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-lipid complex assembly [inference]

plasma lipoprotein particle assembly [inference]

very-low-density lipoprotein particle assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-lipid complex assembly [inference]

plasma lipoprotein particle assembly [inference]

very-low-density lipoprotein particle assembly

protein-lipid complex organization [inference]

protein-lipid complex assembly [inference]

plasma lipoprotein particle assembly [inference]

very-low-density lipoprotein particle assembly

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle assembly [inference]

very-low-density lipoprotein particle assembly

multicellular organismal process [inference]

plasma lipoprotein particle clearance [inference]

low-density lipoprotein particle clearance

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle assembly [inference]

very-low-density lipoprotein particle assembly

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

foam cell differentiation [inference]

macrophage derived foam cell differentiation

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

sterol homeostasis [inference]

cholesterol homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

organic substance transport [inference]

lipid transport [inference]

sterol transport [inference]

cholesterol transport [inference]

cholesterol efflux

organic hydroxy compound transport [inference]

sterol transport [inference]

cholesterol transport [inference]

cholesterol efflux

maintenance of location [inference]

lipid storage [inference]

cholesterol storage

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of glycoprotein biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of protein metabolic process [inference]

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of glycoprotein biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of protein metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of glycoprotein metabolic process [inference]

regulation of glycoprotein biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of glycoprotein biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of protein metabolic process [inference]

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of protein metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of glycoprotein metabolic process [inference]

regulation of glycoprotein biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of glycoprotein metabolic process [inference]

regulation of glycoprotein biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of protein metabolic process [inference]

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of glycoprotein biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IDA	10623671
endoplasmic reticulum membrane	IBA IDA TAS	17412327
membrane	IDA	9756919

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 5** entries
GO Term	Evidence Code	PMID
fatty-acyl-CoA binding	IBA IDA	16647063
cholesterol O-acyltransferase activity	IBA IDA IMP TAS	16647063 24608080 32433613 32433614 8407899
cholesterol binding	IBA IDA	16647063 32433613 32433614
protein binding	IPI	21044950 23169578
sterol O-acyltransferase activity	IDA IMP	8407899 9020103 9756919

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

O-acyltransferase activity [inference]

sterol O-acyltransferase activity

cholesterol O-acyltransferase activity

binding [inference]

protein binding

lipid binding [inference]

steroid binding [inference]

sterol binding [inference]

cholesterol binding

fatty acid derivative binding [inference]

fatty-acyl-CoA binding

amide binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

small molecule binding [inference]

alcohol binding [inference]

cholesterol binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

ion binding [inference]

anion binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

organic cyclic compound binding [inference]

steroid binding [inference]

sterol binding [inference]

cholesterol binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

sulfur compound binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000057252

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Rhea

RHEA:59816

a sterol + a long-chain fatty acyl-CoA

a sterol ester + CoA

Enzyme

2.3.1.26

PMID

RHEA:17729

cholesterol + an acyl-CoA

a cholesterol ester + CoA

Enzyme

2.3.1.26

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of **441** in total

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DO ID	Disease Name	Source
DOID:0040085	bacterial sepsis	DisGeNET
DOID:0050156	idiopathic pulmonary fibrosis	DisGeNET
DOID:0050169	cutaneous lupus erythematosus	DisGeNET
DOID:0050424	familial adenomatous polyposis	DisGeNET
DOID:0050458	juvenile myelomonocytic leukemia	DisGeNET DisGeNET
DOID:0050523	adult T-cell leukemia/lymphoma	DisGeNET
DOID:0050572	cone-rod dystrophy	DisGeNET
DOID:0050589	inflammatory bowel disease	DisGeNET DisGeNET DisGeNET
DOID:0050745	diffuse large B-cell lymphoma	DisGeNET
DOID:0050747	obsolete lymphoplasmacytic lymphoma	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP000054
Gene Name: sterol O-acyltransferase 1

Ortholog

Displaying entries **1 - 10** of 83 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	181681	WB:WBGene00007174
Drosophila melanogaster	41033	FB:FBgn0037612
Callorhinchus milii	103179969		CALMI19230
Latimeria chalumnae	102351870		LATCH08535
Danio rerio	564424	ZFIN:ZDB-GENE-081105-177	DANRE42487
Astyanax mexicanus	103042750		ASTMX02037
Ictalurus punctatus	108265920		ICTPU30448
Salmo salar	106613907		SALSA11388
Salmo trutta	115158397		SALTR109476
Oryzias latipes	101164716		ORYLA13647

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements