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dentin sialophosphoprotein

Summary

Gene Symbol

Dspp

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

666279

PubChem

666279

Alliance of Genome Resources

MGI:109172

Annotation

Keyword

Proteomics identification
Reference proteome
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
E9Q9Z9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 25 in total

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GO Term	Evidence Code	PMID
branching involved in ureteric bud morphogenesis	IMP	16937369
biomineral tissue development	IEA
ameloblast differentiation	IMP	25027178
odontogenesis	IMP	25027178
mesenchymal to epithelial transition	IMP	16937369

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

gene expression involved in extracellular matrix organization

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

gene expression involved in extracellular matrix organization

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

gene expression involved in extracellular matrix organization

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

gene expression involved in extracellular matrix organization

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

gene expression involved in extracellular matrix organization

cellular process [inference]

cell communication [inference]

cellular response to extracellular stimulus [inference]

cellular response to cell-matrix adhesion

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

gene expression involved in extracellular matrix organization

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

columnar/cuboidal epithelial cell differentiation [inference]

ameloblast differentiation

neuroepithelial cell differentiation [inference]

odontoblast differentiation

mesenchymal to epithelial transition

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to cell-matrix adhesion

multicellular organismal process [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

branching involved in ureteric bud morphogenesis

developmental process [inference]

anatomical structure morphogenesis [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

branching involved in ureteric bud morphogenesis

animal organ morphogenesis [inference]

odontogenesis

odontogenesis of dentin-containing tooth [inference]

bone morphogenesis [inference]

endochondral bone morphogenesis

lung morphogenesis

tube morphogenesis [inference]

branching morphogenesis of an epithelial tube [inference]

branching involved in ureteric bud morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

branching involved in ureteric bud morphogenesis

S-shaped body morphogenesis

anatomical structure formation involved in morphogenesis [inference]

anatomical structure development [inference]

tissue development [inference]

animal organ development [inference]

cartilage development [inference]

articular cartilage development [inference]

temporomandibular joint articular cartilage development [inference]

mandibular condyle articular cartilage development

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

columnar/cuboidal epithelial cell differentiation [inference]

ameloblast differentiation

neuroepithelial cell differentiation [inference]

odontoblast differentiation

mesenchymal to epithelial transition

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to cell-matrix adhesion

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to cell-matrix adhesion

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to cell-matrix adhesion

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of calcium ion transport [inference]

positive regulation of calcium ion transport [inference]

positive regulation of calcium ion import

regulation of calcium ion import [inference]

positive regulation of calcium ion import

positive regulation of monoatomic ion transport [inference]

positive regulation of calcium ion transport [inference]

positive regulation of calcium ion import

positive regulation of transport [inference]

positive regulation of monoatomic ion transport [inference]

positive regulation of calcium ion transport [inference]

positive regulation of calcium ion import

regulation of growth [inference]

negative regulation of growth [inference]

negative regulation of developmental growth [inference]

negative regulation of organ growth [inference]

negative regulation of growth plate cartilage chondrocyte proliferation

regulation of developmental growth [inference]

regulation of organ growth [inference]

negative regulation of organ growth [inference]

negative regulation of growth plate cartilage chondrocyte proliferation

negative regulation of developmental growth [inference]

negative regulation of organ growth [inference]

negative regulation of growth plate cartilage chondrocyte proliferation

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of chondrocyte proliferation

positive regulation of transport [inference]

positive regulation of monoatomic ion transport [inference]

positive regulation of calcium ion transport [inference]

positive regulation of calcium ion import

positive regulation of developmental process [inference]

positive regulation of biomineral tissue development [inference]

positive regulation of tooth mineralization [inference]

positive regulation of enamel mineralization

negative regulation of biological process [inference]

negative regulation of growth [inference]

negative regulation of developmental growth [inference]

negative regulation of organ growth [inference]

negative regulation of growth plate cartilage chondrocyte proliferation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of mesenchymal cell apoptotic process

negative regulation of developmental process [inference]

negative regulation of developmental growth [inference]

negative regulation of organ growth [inference]

negative regulation of growth plate cartilage chondrocyte proliferation

negative regulation of bone development

negative regulation of multicellular organismal process [inference]

negative regulation of organ growth [inference]

negative regulation of growth plate cartilage chondrocyte proliferation

negative regulation of bone development

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of epithelial cell differentiation [inference]

regulation of odontoblast differentiation

regulation of developmental growth [inference]

regulation of organ growth [inference]

negative regulation of organ growth [inference]

negative regulation of growth plate cartilage chondrocyte proliferation

negative regulation of developmental growth [inference]

negative regulation of organ growth [inference]

negative regulation of growth plate cartilage chondrocyte proliferation

negative regulation of developmental process [inference]

negative regulation of developmental growth [inference]

negative regulation of organ growth [inference]

negative regulation of growth plate cartilage chondrocyte proliferation

negative regulation of bone development

positive regulation of developmental process [inference]

positive regulation of biomineral tissue development [inference]

positive regulation of tooth mineralization [inference]

positive regulation of enamel mineralization

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation [inference]

regulation of odontoblast differentiation

regulation of biomineral tissue development [inference]

positive regulation of biomineral tissue development [inference]

positive regulation of tooth mineralization [inference]

positive regulation of enamel mineralization

regulation of tooth mineralization [inference]

positive regulation of tooth mineralization [inference]

positive regulation of enamel mineralization

regulation of enamel mineralization [inference]

positive regulation of enamel mineralization

regulation of bone development [inference]

negative regulation of bone development

regulation of cellular process [inference]

regulation of cell population proliferation [inference]

regulation of growth plate cartilage chondrocyte proliferation [inference]

negative regulation of growth plate cartilage chondrocyte proliferation

positive regulation of cell population proliferation [inference]

positive regulation of chondrocyte proliferation

negative regulation of cell population proliferation [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of mesenchymal cell apoptotic process

regulation of mesenchymal cell apoptotic process [inference]

negative regulation of mesenchymal cell apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of mesenchymal cell apoptotic process

regulation of cell differentiation [inference]

regulation of epithelial cell differentiation [inference]

regulation of odontoblast differentiation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of chondrocyte proliferation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of mesenchymal cell apoptotic process

regulation of multicellular organismal process [inference]

regulation of organ growth [inference]

negative regulation of organ growth [inference]

negative regulation of growth plate cartilage chondrocyte proliferation

negative regulation of multicellular organismal process [inference]

negative regulation of organ growth [inference]

negative regulation of growth plate cartilage chondrocyte proliferation

negative regulation of bone development

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation [inference]

regulation of odontoblast differentiation

regulation of biomineral tissue development [inference]

positive regulation of biomineral tissue development [inference]

positive regulation of tooth mineralization [inference]

positive regulation of enamel mineralization

regulation of tooth mineralization [inference]

positive regulation of tooth mineralization [inference]

positive regulation of enamel mineralization

regulation of enamel mineralization [inference]

positive regulation of enamel mineralization

regulation of bone development [inference]

negative regulation of bone development

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
extracellular space	IDA	25027178
nucleus	ISO	23525114
nucleus	IDA	19001636
nucleus	IBA
cytoplasm	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	23525114
collagen binding	ISO
collagen binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

protein-containing complex binding [inference]

collagen binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

dentin sialophosphoprotein

Functional Category

M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms
X: Mobilome: prophages, transposons

Displaying **all 3** entries
Gene Ontology
collagen binding
dentinogenesis
odontoblast differentiation

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:3388	periodontal disease	Alliance of Genome Resources
DOID:4154	dentinogenesis imperfecta	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 22 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	1834	HGNC:3054	HUMAN76495
Rattus norvegicus	25254		RATNO08831
Sus scrofa	396664		PIGXX34466
Homo sapiens	666279	HGNC:3054
Bos taurus	100337125		BOVIN31819
Callithrix jacchus	100395778		CALJA29374
Nomascus leucogenys	100580167		NOMLE37077
Otolemur garnettii	100960058		OTOGA11749
Pan troglodytes	101056811		PANTR34080
Gorilla gorilla gorilla	101138922		GORGO31277

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Annotation

OrthoDB (Group)

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Acknowledgements