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secreted phosphoprotein 1

Summary

Gene Symbol

SPP1

Organism

Homo sapiens (human)

External Links

NCBI Gene

6696

PubChem

6696

Alliance of Genome Resources

HGNC:11255

Annotation

Keyword

3D-structure
Alternative splicing
Biomineralization
Cell adhesion
Cytokine
Direct protein sequencing
Phosphoprotein
Proteoglycan
Proteomics identification
Reference proteome
Secreted
Sialic acid
Signal

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P10451	Bone sialoprotein 1 Nephropontin Secreted phosphoprotein 1 Urinary stone protein Uropontin
B7Z351
Q3LGB0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
embryo implantation	TAS	16720713
cellular response to testosterone stimulus	IDA	26482249
biomineral tissue development	IEA
response to steroid hormone	IEA
negative regulation of collateral sprouting of intact axon in response to injury	IEA

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

hormone catabolic process [inference]

androgen catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

steroid catabolic process [inference]

androgen catabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process [inference]

androgen catabolic process

hormone metabolic process [inference]

androgen metabolic process [inference]

androgen catabolic process

hormone catabolic process [inference]

androgen catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid catabolic process [inference]

androgen catabolic process

androgen metabolic process [inference]

androgen catabolic process

lipid catabolic process [inference]

steroid catabolic process [inference]

androgen catabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid catabolic process [inference]

androgen catabolic process

androgen metabolic process [inference]

androgen catabolic process

lipid catabolic process [inference]

steroid catabolic process [inference]

androgen catabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid catabolic process [inference]

androgen catabolic process

androgen metabolic process [inference]

androgen catabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process [inference]

androgen catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

steroid catabolic process [inference]

androgen catabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process [inference]

androgen catabolic process

cellular process [inference]

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to testosterone stimulus

cellular response to organic cyclic compound [inference]

cellular response to testosterone stimulus

cellular response to oxygen-containing compound [inference]

cellular response to ketone [inference]

cellular response to testosterone stimulus

reproductive process [inference]

developmental process involved in reproduction [inference]

decidualization

embryo implantation

developmental process [inference]

developmental process involved in reproduction [inference]

decidualization

anatomical structure development [inference]

tissue development [inference]

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin D

response to endogenous stimulus [inference]

response to hormone [inference]

response to steroid hormone

response to chemical [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin D

response to organic substance [inference]

response to hormone [inference]

response to steroid hormone

response to organic cyclic compound [inference]

response to vitamin D

response to testosterone [inference]

cellular response to testosterone stimulus

response to steroid hormone

cellular response to organic cyclic compound [inference]

cellular response to testosterone stimulus

response to 2,3,7,8-tetrachlorodibenzodioxine

response to lipid [inference]

response to vitamin D

response to testosterone [inference]

cellular response to testosterone stimulus

response to steroid hormone

cellular response to lipid [inference]

cellular response to testosterone stimulus

response to cytokine [inference]

response to macrophage colony-stimulating factor

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to testosterone stimulus

cellular response to organic cyclic compound [inference]

cellular response to testosterone stimulus

response to ketone [inference]

response to testosterone [inference]

cellular response to testosterone stimulus

cellular response to ketone [inference]

cellular response to testosterone stimulus

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to testosterone stimulus

cellular response to organic cyclic compound [inference]

cellular response to testosterone stimulus

cellular response to oxygen-containing compound [inference]

cellular response to ketone [inference]

cellular response to testosterone stimulus

response to oxygen-containing compound [inference]

response to vitamin D

response to ketone [inference]

response to testosterone [inference]

cellular response to testosterone stimulus

cellular response to ketone [inference]

cellular response to testosterone stimulus

cellular response to oxygen-containing compound [inference]

cellular response to ketone [inference]

cellular response to testosterone stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to testosterone stimulus

cellular response to organic cyclic compound [inference]

cellular response to testosterone stimulus

cellular response to oxygen-containing compound [inference]

cellular response to ketone [inference]

cellular response to testosterone stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of signaling [inference]

positive regulation of signaling [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of steroid hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of estradiol secretion [inference]

positive regulation of estradiol secretion

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of steroid hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of estradiol secretion [inference]

positive regulation of estradiol secretion

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of steroid hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of estradiol secretion [inference]

positive regulation of estradiol secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of lipid localization [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of steroid hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of estradiol secretion [inference]

positive regulation of estradiol secretion

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of growth [inference]

regulation of cell growth [inference]

negative regulation of cell growth [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

regulation of extent of cell growth [inference]

regulation of collateral sprouting [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

regulation of collateral sprouting of intact axon in response to injury [inference]

negative regulation of collateral sprouting of intact axon in response to injury

negative regulation of growth [inference]

negative regulation of cell growth [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

negative regulation of developmental growth [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

regulation of developmental growth [inference]

negative regulation of developmental growth [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

regulation of collateral sprouting [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

regulation of collateral sprouting of intact axon in response to injury [inference]

negative regulation of collateral sprouting of intact axon in response to injury

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of signaling [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

positive regulation of multicellular organismal process [inference]

positive regulation of bone resorption

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

negative regulation of biological process [inference]

negative regulation of growth [inference]

negative regulation of cell growth [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

negative regulation of developmental growth [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

negative regulation of cellular process [inference]

negative regulation of cell growth [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

negative regulation of neuron projection regeneration [inference]

negative regulation of axon regeneration [inference]

negative regulation of collateral sprouting of intact axon in response to injury

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of axon regeneration [inference]

negative regulation of collateral sprouting of intact axon in response to injury

negative regulation of neuron projection regeneration [inference]

negative regulation of axon regeneration [inference]

negative regulation of collateral sprouting of intact axon in response to injury

negative regulation of response to wounding [inference]

negative regulation of axon regeneration [inference]

negative regulation of collateral sprouting of intact axon in response to injury

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

negative regulation of developmental growth [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

negative regulation of neuron projection regeneration [inference]

negative regulation of axon regeneration [inference]

negative regulation of collateral sprouting of intact axon in response to injury

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of axon regeneration [inference]

negative regulation of collateral sprouting of intact axon in response to injury

regulation of axon regeneration [inference]

negative regulation of axon regeneration [inference]

negative regulation of collateral sprouting of intact axon in response to injury

regulation of collateral sprouting of intact axon in response to injury [inference]

negative regulation of collateral sprouting of intact axon in response to injury

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of axon regeneration [inference]

negative regulation of collateral sprouting of intact axon in response to injury

negative regulation of neuron projection regeneration [inference]

negative regulation of axon regeneration [inference]

negative regulation of collateral sprouting of intact axon in response to injury

negative regulation of response to wounding [inference]

negative regulation of axon regeneration [inference]

negative regulation of collateral sprouting of intact axon in response to injury

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of neuron projection regeneration [inference]

regulation of axon regeneration [inference]

negative regulation of axon regeneration [inference]

negative regulation of collateral sprouting of intact axon in response to injury

regulation of collateral sprouting of intact axon in response to injury [inference]

negative regulation of collateral sprouting of intact axon in response to injury

negative regulation of neuron projection regeneration [inference]

negative regulation of axon regeneration [inference]

negative regulation of collateral sprouting of intact axon in response to injury

regulation of response to wounding [inference]

regulation of axon regeneration [inference]

negative regulation of axon regeneration [inference]

negative regulation of collateral sprouting of intact axon in response to injury

regulation of collateral sprouting of intact axon in response to injury [inference]

negative regulation of collateral sprouting of intact axon in response to injury

negative regulation of response to wounding [inference]

negative regulation of axon regeneration [inference]

negative regulation of collateral sprouting of intact axon in response to injury

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of axonogenesis [inference]

regulation of collateral sprouting [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

regulation of collateral sprouting of intact axon in response to injury [inference]

negative regulation of collateral sprouting of intact axon in response to injury

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

regulation of developmental growth [inference]

negative regulation of developmental growth [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

regulation of collateral sprouting [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

regulation of collateral sprouting of intact axon in response to injury [inference]

negative regulation of collateral sprouting of intact axon in response to injury

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

negative regulation of developmental growth [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

negative regulation of neuron projection regeneration [inference]

negative regulation of axon regeneration [inference]

negative regulation of collateral sprouting of intact axon in response to injury

regulation of neuron projection regeneration [inference]

regulation of axon regeneration [inference]

negative regulation of axon regeneration [inference]

negative regulation of collateral sprouting of intact axon in response to injury

regulation of collateral sprouting of intact axon in response to injury [inference]

negative regulation of collateral sprouting of intact axon in response to injury

negative regulation of neuron projection regeneration [inference]

negative regulation of axon regeneration [inference]

negative regulation of collateral sprouting of intact axon in response to injury

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

regulation of cellular process [inference]

signal transduction

regulation of cell communication [inference]

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of steroid hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of estradiol secretion [inference]

positive regulation of estradiol secretion

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

negative regulation of cellular process [inference]

negative regulation of cell growth [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

negative regulation of neuron projection regeneration [inference]

negative regulation of axon regeneration [inference]

negative regulation of collateral sprouting of intact axon in response to injury

regulation of cellular component organization [inference]

regulation of cell growth [inference]

negative regulation of cell growth [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

regulation of extent of cell growth [inference]

regulation of collateral sprouting [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

regulation of collateral sprouting of intact axon in response to injury [inference]

negative regulation of collateral sprouting of intact axon in response to injury

regulation of cell projection organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

negative regulation of neuron projection regeneration [inference]

negative regulation of axon regeneration [inference]

negative regulation of collateral sprouting of intact axon in response to injury

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

negative regulation of neuron projection regeneration [inference]

negative regulation of axon regeneration [inference]

negative regulation of collateral sprouting of intact axon in response to injury

regulation of axonogenesis [inference]

regulation of collateral sprouting [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

regulation of collateral sprouting of intact axon in response to injury [inference]

negative regulation of collateral sprouting of intact axon in response to injury

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

regulation of neuron projection regeneration [inference]

regulation of axon regeneration [inference]

negative regulation of axon regeneration [inference]

negative regulation of collateral sprouting of intact axon in response to injury

regulation of collateral sprouting of intact axon in response to injury [inference]

negative regulation of collateral sprouting of intact axon in response to injury

negative regulation of neuron projection regeneration [inference]

negative regulation of axon regeneration [inference]

negative regulation of collateral sprouting of intact axon in response to injury

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

negative regulation of neuron projection regeneration [inference]

negative regulation of axon regeneration [inference]

negative regulation of collateral sprouting of intact axon in response to injury

regulation of cellular response to stress [inference]

regulation of neuron projection regeneration [inference]

regulation of axon regeneration [inference]

negative regulation of axon regeneration [inference]

negative regulation of collateral sprouting of intact axon in response to injury

regulation of collateral sprouting of intact axon in response to injury [inference]

negative regulation of collateral sprouting of intact axon in response to injury

negative regulation of neuron projection regeneration [inference]

negative regulation of axon regeneration [inference]

negative regulation of collateral sprouting of intact axon in response to injury

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of steroid hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of estradiol secretion [inference]

positive regulation of estradiol secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of multicellular organismal process [inference]

regulation of tissue remodeling [inference]

regulation of bone remodeling [inference]

regulation of bone resorption [inference]

positive regulation of bone resorption

regulation of system process [inference]

regulation of endocrine process [inference]

regulation of steroid hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of estradiol secretion [inference]

positive regulation of estradiol secretion

positive regulation of multicellular organismal process [inference]

positive regulation of bone resorption

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting [inference]

negative regulation of collateral sprouting of intact axon in response to injury

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

androgen metabolic process [inference]

androgen catabolic process

hormone catabolic process [inference]

androgen catabolic process

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of steroid hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of estradiol secretion [inference]

positive regulation of estradiol secretion

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
Golgi apparatus	IDA
endoplasmic reticulum lumen	TAS
cell projection	IEA
extracellular region	TAS
extracellular space	HDA IBA IDA	15516325 16502470

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

cell projection

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

Golgi apparatus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

perinuclear region of cytoplasm

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	10747989 11162539 16189514 21988832 22582013 25416956 25789606 25910212 26091039 32296183 32814053 8560266
integrin binding	IPI	25839998
extracellular matrix binding	IBA
small molecule binding	EXP	33914399
cytokine activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

integrin binding

receptor ligand activity [inference]

cytokine activity

cell adhesion molecule binding [inference]

integrin binding

small molecule binding

protein-containing complex binding [inference]

integrin binding

extracellular matrix binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

secreted phosphoprotein 1

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
extracellular matrix binding
ossification
osteoblast differentiation
positive regulation of bone resorption

Displaying **all 2** entries
InterPro
Osteopontin, conserved site
Osteopontin

Disease

Disease Ontology

Displaying entries **1 - 10** of 30 in total

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DO ID	Disease Name	Source
DOID:0050851	glomerulosclerosis	Alliance of Genome Resources
DOID:0080685	aortic dissection	Alliance of Genome Resources
DOID:0111535	progressive osseous heteroplasia	Alliance of Genome Resources
DOID:10286	prostate carcinoma	Alliance of Genome Resources
DOID:1074	kidney failure	Alliance of Genome Resources
DOID:11054	urinary bladder cancer	Alliance of Genome Resources
DOID:11832	visual epilepsy	Alliance of Genome Resources
DOID:13608	biliary atresia	Alliance of Genome Resources
DOID:14566	disease of cellular proliferation	Alliance of Genome Resources
DOID:1591	renovascular hypertension	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	20750		MGI:98389	MOUSE43572
Rattus norvegicus	25353		RGD:3752	RATNO09046
Sus scrofa	397087			PIGXX34459
Danio rerio	432385		ZFIN:ZDB-GENE-050706-97
Ovis aries	443058			SHEEP17244
Pan troglodytes	461366	9598_0:0015fb		PANTR34091
Canis lupus familiaris	478471			CANLF13056
Macaca mulatta	704930			MACMU36992
Oryctolagus cuniculus	100008982			RABIT05239
Monodelphis domestica	100016723			MONDO27205

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements