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SRC proto-oncogene, non-receptor tyrosine kinase
Summary
- Gene Symbol
-
- SRC
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Alternative splicing
- Cell adhesion
- Cell cycle
- Cell junction
- Cell membrane
- Cytoskeleton
- Disease variant
- Host-virus interaction
- Immunity
- Mitochondrion inner membrane
- Myristate
- Nucleus
- Phosphoprotein
- Proto-oncogene
- Reference proteome
- SH2 domain
- SH3 domain
- Tyrosine-protein kinase
- Ubl conjugation
- Proteins
| UniProt | Protein Name |
|---|---|
| P12931 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| negative regulation of intrinsic apoptotic signaling pathway | ||
| regulation of caveolin-mediated endocytosis |
GO Hierarchy
- integrin-mediated signaling pathway
- intracellular signal transduction
- integrin-mediated signaling pathway
- intracellular signal transduction
biological process
immune system process [inference]
metabolic process [inference]
cellular process [inference]
signal transduction
immune response-regulating signaling pathway [inference]
cell surface receptor signaling pathway [inference]
immune response-regulating cell surface receptor signaling pathway [inference]
enzyme-linked receptor protein signaling pathway [inference]
cellular metabolic process [inference]
cellular response to stimulus [inference]
developmental process [inference]
response to stimulus [inference]
response to endogenous stimulus [inference]
response to chemical [inference]
cellular response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of nitrogen compound metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
positive regulation of phosphorus metabolic process [inference]
regulation of phosphate metabolic process [inference]
regulation of nucleotide metabolic process [inference]
regulation of phosphorylation [inference]
positive regulation of phosphate metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of nitrogen compound metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
negative regulation of macromolecule metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of small molecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of signaling [inference]
regulation of signal transduction [inference]
positive regulation of signaling [inference]
regulation of localization [inference]
positive regulation of biological process [inference]
positive regulation of immune system process [inference]
positive regulation of metabolic process [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of nitrogen compound metabolic process [inference]
positive regulation of signaling [inference]
positive regulation of cellular process [inference]
positive regulation of cell communication [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of response to stimulus [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of signal transduction [inference]
regulation of response to external stimulus [inference]
positive regulation of response to stimulus [inference]
negative regulation of response to stimulus [inference]
regulation of immune response [inference]
regulation of cellular process [inference]
signal transduction
immune response-regulating signaling pathway [inference]
cell surface receptor signaling pathway [inference]
immune response-regulating cell surface receptor signaling pathway [inference]
enzyme-linked receptor protein signaling pathway [inference]
regulation of cell communication [inference]
regulation of signal transduction [inference]
positive regulation of cell communication [inference]
regulation of cell adhesion [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
positive regulation of phosphorus metabolic process [inference]
regulation of phosphate metabolic process [inference]
regulation of nucleotide metabolic process [inference]
regulation of phosphorylation [inference]
positive regulation of phosphate metabolic process [inference]
regulation of cell population proliferation [inference]
regulation of programmed cell death [inference]
regulation of cellular component biogenesis [inference]
positive regulation of cellular process [inference]
positive regulation of cell communication [inference]
positive regulation of cellular metabolic process [inference]
negative regulation of cellular process [inference]
regulation of cell activation [inference]
regulation of cellular component organization [inference]
regulation of cellular localization [inference]
regulation of multicellular organismal process [inference]
regulation of molecular function [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| heme binding | ||
| protein tyrosine kinase activator activity | ||
| nuclear estrogen receptor binding | ||
| SH2 domain binding | ||
| phospholipase binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Kinase
- Functional Category
-
- J: Translation, ribosomal structure and biogenesis
- K: Transcription
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| ATP binding |
| kinase activity |
| nucleotide binding |
| phosphorylation |
| InterPro |
|---|
| Protein kinase domain |
| Protein kinase-like domain superfamily |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060074 | ductal carcinoma in situ | |
| DOID:10283 | prostate cancer | |
| DOID:1588 | thrombocytopenia | |
| DOID:219 | colon cancer | |
| DOID:234 | colon adenocarcinoma | |
| DOID:9256 | colorectal cancer | |
| DOID:9352 | type 2 diabetes mellitus |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 101962014 | ICTTR02237 | ||
| 102006840 | CHILA11956 | ||
| 102182890 | CAPHI04147 | ||
| 102360542 | LATCH17428 | ||
| 102430207 | MYOLU05450 | ||
| 102462669 | PELSI15707 | ||
| 103109387 | ERIEU07520 | ||
| 103273857 | CARSF12904 | ||
| 103752029 | NANGA23966 | ||
| 103818614 | SERCA13251 |
