GlyCosmos Portal

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GO Term	Evidence Code	PMID
delta4-3-oxosteroid 5beta-reductase activity	IEA
alditol:NADP+ 1-oxidoreductase activity	IBA
steroid binding		7508385
aldo-keto reductase (NADP) activity
ketosteroid monooxygenase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [inference]

ketosteroid monooxygenase activity

steroid dehydrogenase activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

aldo-keto reductase (NADP) activity

alcohol dehydrogenase (NADP+) activity [inference]

alditol:NADP+ 1-oxidoreductase activity

oxidoreductase activity, acting on the CH-CH group of donors [inference]

oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [inference]

enone reductase activity [inference]

delta4-3-oxosteroid 5beta-reductase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [inference]

ketosteroid monooxygenase activity

binding [inference]

lipid binding [inference]

steroid binding

organic cyclic compound binding [inference]

steroid binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K00251

Name

3-oxo-5-beta-steroid 4-dehydrogenase [EC:1.3.1.3]

References

Rhea

RHEA:11524

5β-cholestan-3-one + NADP⁺

H⁺ + cholest-4-en-3-one + NADPH

Enzyme

1.3.1.3

PMID

RHEA:54412

a 3-oxo-5β-steroid + NADP⁺

H⁺ + a 3-oxo-Δ⁴-steroid + NADPH

Enzyme

1.3.1.3

PMID

RHEA:46636

5β-dihydrotestosterone + NADP⁺

H⁺ + testosterone + NADPH

Enzyme

1.3.1.3

PMID

RHEA:14037

4,5β-dihydrocortisone + NADP⁺

H⁺ + cortisone + NADPH

Enzyme

1.3.1.3

PMID

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:9408	acute myocardial infarction	DisGeNET
DOID:9452	steatotic liver disease	DisGeNET DisGeNET

The Human Phenotype Ontology

Displaying entries **1 - 10** of 29 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000107	Renal cyst
HP:0000952	Jaundice
HP:0001396	Cholestasis
HP:0001397	Hepatic steatosis
HP:0001399	Hepatic failure
HP:0001406	Intrahepatic cholestasis
HP:0001508	Failure to thrive
HP:0001744	Splenomegaly
HP:0001978	Extramedullary hematopoiesis

Displaying **all 2** entries
Disease ID	Disease Name
ORPHA:79303	congenital bile acid synthesis defect 2
OMIM:235555	congenital bile acid synthesis defect 2

PubChem Disease

GHR Health Conditions

Congenital bile acid synthesis defect type 2

MedGen Diseases

Congenital bile acid synthesis defect 2

OMIM Phenotypes

BILE ACID SYNTHESIS DEFECT, CONGENITAL, 2; CBAS2

KEGG Diseases

Congenital bile acid synthesis defect

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001665
Gene Name: aldo-keto reductase family 1, member D1

Ortholog

Displaying entries **11 - 20** of **107** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Salmo trutta	115196975		SALTR11623
Gadus morhua	115550949		GADMO61517
Poecilia reticulata	103465917		POERE28289
Oryzias latipes	101170970		ORYLA10928
Oreochromis niloticus	100710661		ORENI69919
Oreochromis niloticus	109194203		ORENI26245
Haplochromis burtoni	102293767		HAPBU12948
Astatotilapia calliptera	113026470		ASTCA37845
Xenopus laevis	399023	Xenbase:XB-GENE-17341435
Xenopus laevis	734699	Xenbase:XB-GENE-947172

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements